Direct Inhibition of the YAP : TEAD Interaction: An Unprecedented Drug Discovery Challenge von Chene, Patrick

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Study of the TEAD-binding domain of the VGLL1, VGLL2 and VGLL3 proteins from vertebrates von Mesrouze, Yannick, Chène, Patrick

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Inhibiting the p53–MDM2 interaction: an important target for cancer therapy von Chene, Patrick

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Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors von Holzer, Philipp, Masuya, Keiichi, Furet, Pascal, Kallen, Joerg, Valat-Stachyra, Therese, Ferretti, Stéphane, Berghausen, Joerg, Bouisset-Leonard, Michèle, Buschmann, Nicole, Pissot-Soldermann, Carole, Rynn, Caroline, Ruetz, Stephan, Stutz, Stefan, Chène, Patrick, Jeay, Sébastien, Gessier, Francois

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An Early Association between the α‑Helix of the TEAD Binding Domain of YAP and TEAD Drives the Formation of the YAP:TEAD Complex von Bokhovchuk, Fedir, Mesrouze, Yannick, Meyerhofer, Marco, Zimmermann, Catherine, Fontana, Patrizia, Erdmann, Dirk, Jemth, Per, Chène, Patrick

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor a... von Maira, Sauveur-Michel, Stauffer, Frédéric, Brueggen, Josef, Furet, Pascal, Schnell, Christian, Fritsch, Christine, Brachmann, Saskia, Chène, Patrick, De Pover, Alain, Schoemaker, Kevin, Fabbro, Doriano, Gabriel, Daniela, Simonen, Marjo, Murphy, Leon, Finan, Peter, Sellers, William, García-Echeverría, Carlos

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Drugs Targeting Protein-Protein Interactions von Chène, Patrick

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Design and Biochemical Characterization of Peptidic Inhibitors of the Myb/p300 Interaction von Jones, Matthew, Grosche, Philipp, Floersheimer, Andreas, André, Jérome, Gattlen, Raphael, Oser, Dieter, Tinchant, Juliette, Wille, Roman, Chie-Leon, Barbara, Gerspacher, Marc, Ertl, Peter, Ostermann, Nils, Altmann, Eva, Manchado, Eusebio, Vorherr, Thomas, Chène, Patrick

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Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence von Furet, Pascal, Salem, Bahaa, Mesrouze, Yannick, Schmelzle, Tobias, Lewis, Ian, Kallen, Joerg, Chène, Patrick

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Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor von Maira, Sauveur-Michel, Pecchi, Sabina, Huang, Alan, Burger, Matthew, Knapp, Mark, Sterker, Dario, Schnell, Christian, Guthy, Daniel, Nagel, Tobi, Wiesmann, Marion, Brachmann, Saskia, Fritsch, Christine, Dorsch, Marion, Chène, Patrick, Shoemaker, Kevin, De Pover, Alain, Menezes, Daniel, Martiny-Baron, Georg, Fabbro, Doriano, Wilson, Christopher J, Schlegel, Robert, Hofmann, Francesco, García-Echeverría, Carlos, Sellers, William R, Voliva, Charles F

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Biochemical properties of VGLL4 from Homo sapiens and Tgi from Drosophila melanogaster and possible biological implications von Mesrouze, Yannick, Meyerhofer, Marco, Zimmermann, Catherine, Fontana, Patrizia, Erdmann, Dirk, Chène, Patrick

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Study of the TEAD‐binding domain of the YAP protein from animal species von Mesrouze, Yannick, Bokhovchuk, Fedir, Meyerhofer, Marco, Zimmermann, Catherine, Fontana, Patrizia, Erdmann, Dirk, Chène, Patrick

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Effect of the acylation of TEAD4 on its interaction with co‐activators YAP and TAZ von Mesrouze, Yannick, Meyerhofer, Marco, Bokhovchuk, Fedir, Fontana, Patrizia, Zimmermann, Catherine, Martin, Typhaine, Delaunay, Clara, Izaac, Aude, Kallen, Joerg, Schmelzle, Tobias, Erdmann, Dirk, Chène, Patrick

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Can biochemistry drive drug discovery beyond simple potency measurements? von CHENE, Patrick

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M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth von Cortés-Cros, Marta, Hemmerlin, Christelle, Ferretti, Stephane, Zhang, Juan, Gounarides, John S., Yin, Hong, Muller, Alban, Haberkorn, Anne, Chene, Patrick, Sellers, William R., Hofmann, Francesco

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Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain von McNally, Randall, Li, Qing, Li, Kunhua, Dekker, Carien, Vangrevelinghe, Eric, Jones, Matthew, Chène, Patrick, Machauer, Rainer, Radimerski, Thomas, Eck, Michael J

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ATPases as drug targets: learning from their structure von Chene, Patrick

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Discovery of a novel class of highly potent inhibitors of the p53–MDM2 interaction by structure-based design starting from a conformational argument von Furet, Pascal, Masuya, Keiichi, Kallen, Joerg, Stachyra-Valat, Thérèse, Ruetz, Stephan, Guagnano, Vito, Holzer, Philipp, Mah, Robert, Stutz, Stefan, Vaupel, Andrea, Chène, Patrick, Jeay, Sébastien, Schlapbach, Achim

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Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy von Bokhovchuk, Fedir, Mesrouze, Yannick, Izaac, Aude, Meyerhofer, Marco, Zimmermann, Catherine, Fontana, Patrizia, Schmelzle, Tobias, Erdmann, Dirk, Furet, Pascal, Kallen, Joerg, Chène, Patrick

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Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface von Mesrouze, Yannick, Bokhovchuk, Fedir, Izaac, Aude, Meyerhofer, Marco, Zimmermann, Catherine, Fontana, Patrizia, Schmelzle, Tobias, Erdmann, Dirk, Furet, Pascal, Kallen, Joerg, Chène, Patrick

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