From fragments to leads: novel bacterial NAD+-dependent DNA ligase inhibitors von Hale, Michael R., Brassington, Claire, Carcanague, Dan, Embrey, Kevin, Eyermann, Charles J., Giacobbe, Robert A., Gingipalli, Lakshmaiah, Gowravaram, Madhusudhan, Harang, Jenna, Howard, Tina, Ioannidis, Georgine, Jahic, Haris, Kutschke, Amy, Laganas, Valerie A., Loch, James, Miller, Matthew D., Murphy-Benenato, Kerry E., Oguto, Herbert, Otterbein, Ludovic, Patel, Sahil Joe, Shapiro, Adam B., Boriack-Sjodin, P. Ann

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Negishi cross-coupling enabled synthesis of novel NAD+-dependent DNA ligase inhibitors and SAR development von Murphy-Benenato, Kerry E., Gingipalli, Lakshmaiah, Boriack-Sjodin, P. Ann, Martinez-Botella, Gabriel, Carcanague, Dan, Eyermann, Charles J., Gowravaram, Madhu, Harang, Jenna, Hale, Michael R., Ioannidis, Georgine, Jahic, Harris, Johnstone, Michele, Kutschke, Amy, Laganas, Valerie A., Loch, James T., Miller, Matthew D., Oguto, Herbert, Patel, Sahil Joe

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Abstract 2158: Preclinical evaluation of CFT1946 as a selective degrader of mutant BRAF for the treatment of BRAF driven cancers von Sowa, Mathew E., Kreger, Bridget, Baddour, Joelle, Liang, Yanke, Simard, Jeffrey R., Poling, Laura, Li, Ping, Yu, Robert, Hart, Ashley, Agafonov, Roman V., Sarkissian, Grace, Patel, Joe Sahil, Deibler, Richard, Cole, Kyle S., Eron, Scott, Cocozziello, David, Rahman, Fazlur, Moustakim, Moses, Nasveschuk, Christopher G., Jackson, Katrina L., Fitzgerald, Mark, Garza, Victoria, O’Shea, Morgan, Veits, Gesine, Yap, Jeremy L., Phillips, Andrew J., Norton, Elizabeth, Crystal, Adam S., Fisher, Stewart L., Pollock, Roy M.

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Development of an AchillesTAG degradation system and its application to control CAR-T activity von Veits, Gesine K., Henderson, Christina S., Vogelaar, Abigail, Eron, Scott J., Lee, Linda, Hart, Ashley, Deibler, Richard W., Baddour, Joelle, Elam, W. Austin, Agafonov, Roman V., Freda, Jessica, Chaturvedi, Prasoon, Ladd, Brendon, Carlson, Mark W., Vora, Harit U., Scott, Thomas G., Tieu, Trang, Jain, Arushi, Chen, Chi-Li, Kibbler, Emily S., Pop, Marius S., He, Minsheng, Kern, Gunther, Maple, Hannah J., Marsh, Graham P., Norley, Mark C., Oakes, Catherine S., Henderson, James A., Sowa, Mathew E., Phillips, Andrew J., Proia, David A., Park, Eunice S., Patel, Joe Sahil, Fisher, Stewart L., Nasveschuk, Christopher G., Zeid, Rhamy

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CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME (BACE) MUTANTS AND USES THEREOF von VUILLARD, LAURENT M.M, SHAH, ALEEM, CLEASBY, ANNE, YON, JEFFREY, ROLAND, HAMILTON, BRUCE, JOHN, PATEL, SAHIL, JOE

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Crystal structure of beta site APP cleaving enzyme (BACE) and methods of use thereof von SHAH ALEEM, PATEL SAHIL JOE, YON JEFFREY ROLAND, HAMILTON BRUCE JOHN, CLEASBY ANNE, VUILLARD LAURENT MICHEL MARIE

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CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME (BACE) MUTANTS AND USES THEREOF von SHAH, ALEEM, VUILLARD, LAURENT, MICHEL, MARIE, CLEASBY, ANNE, YON, JEFFREY, ROLAND, HAMILTON, BRUCE, JOHN, PATEL, SAHIL, JOE

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Crystal structure of beta-site app-cleaving enzyme (bace) mutants and uses thereof von LAURENT MICHEL MARIE VUILLARD, BRUCE JOHN HAMILTON, ALEEM SHAH, JEFFREY ROLAND YON, ANNE CLEASBY, SAHIL JOE PATEL

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CRYSTAL STRUCTURE OF BETA SITE APP CLEAVING ENZYME (BACE) AND METHODS OF USE THEREOF von BRUCE, JOHN HAMILTON, LAURENT, MICHEL, MARIE VUILLARD, JEFFREY, ROLAND YON, SAHIL, JOE PATEL, ALEEM SHAH, ANNE CLEASBY

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CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME (BACE) MUTANTS AND USES THEREOF von SHAH, ALEEM, VUILLARD, LAURENT, MICHEL, MARIE, CLEASBY, ANNE, YON, JEFFREY, ROLAND, HAMILTON, BRUCE, JOHN, PATEL, SAHIL, JOE

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