JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans von Fourie, Anne M., Cheng, Xiaoli, Chang, Leon, Greving, Carrie, Li, Xinyi, Knight, Beverly, Polidori, David, Patrick, Aaron, Bains, Trpta, Steele, Ruth, Allen, Samantha J., Patch, Raymond J., Sun, Chengzao, Somani, Sandeep, Bhandari, Ashok, Liu, David, Huie, Keith, Li, Shu, Rodriguez, Michael A., Xue, Xiaohua, Kannan, Arun, Kosoglou, Teddy, Sherlock, Jonathan P., Towne, Jennifer, Holland, M. Claire, Modi, Nishit B.

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Design, synthesis and preclinical evaluation of bio-conjugated amylinomimetic peptides as long-acting amylin receptor agonists von Patch, Raymond J., Zhang, Rui, Edavettal, Suzanne, Macielag, Mark J., Eckardt, Annette J., Li, Jiali, Rives, Marie-Laure, Edwards, Wilson, Hinke, Simon A., Qiu, Xi, Jian, Wenying, Libiger, Ondrej, Zheng, Songmao, Jeyaseelan, Jey, Liang, Yin, Rangwala, Shamina M., Leonard, James N., Hornby, Pamela

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Indazole-based ligands for estrogen-related receptor α as potential anti-diabetic agents von Patch, Raymond J., Huang, Hui, Patel, Sharmila, Cheung, Wing, Xu, Guozhang, Zhao, Bao-Ping, Beauchamp, Derek A., Rentzeperis, Dionisios, Geisler, John G., Askari, Hossein B., Liu, Jianying, Kasturi, Jyotsna, Towers, Meghan, Gaul, Micheal D., Player, Mark R.

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A Tandem Heck-Carbocyclization/Suzuki-Coupling Approach to the Stereoselective Syntheses of Asymmetric 3,3-(Diarylmethylene)indolinones von Cheung, Wing S, Patch, Raymond J, Player, Mark R

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Identification of Diaryl Ether-Based Ligands for Estrogen-Related Receptor α as Potential Antidiabetic Agents von Patch, Raymond J, Searle, Lily L, Kim, Alexander J, De, Debyendu, Zhu, Xizhen, Askari, Hossein B, O’Neill, John C, Abad, Marta C, Rentzeperis, Dionisios, Liu, Jianying, Kemmerer, Michael, Lin, Ling, Kasturi, Jyotsna, Geisler, John G, Lenhard, James M, Player, Mark R, Gaul, Micheal D

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Discovery of novel potent imidazo[1,2-b]pyridazine PDE10a inhibitors von Meegalla, Sanath K., Huang, Hui, Illig, Carl R., Parks, Daniel J., Chen, Jinsheng, Lee, Yu-Kai, Wilson, Kenneth J., Patel, Sharmila K., Cheung, Wing S., Lu, Tianbao, Kirchner, Thomas, Askari, Hossein B., Geisler, John, Patch, Raymond J., Gibbs, Alan C., Rady, Brian, Connelly, Margery, Player, Mark R.

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Conjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activity von Camacho, Raul C., You, Seohee, D’Aquino, Katharine E., Li, Wenyu, Wang, Yuanping, Gunnet, Joseph, Littrell, James, Qi, Jian Shen, Kang, Lijuan, Jian, Wenying, MacDonald, Mary, Tat, Timothy, Steiner, Derek, Zhang, Yue-Mei, Lanter, James, Patch, Raymond, Zhang, Rui, Li, Jiali, Edavettal, Suzanne, Edwards, Wilson, Dinh, Thai, Wang, Li Ying, Connor, Judy, Hunter, Michael, Chi, Ellen, Swanson, Ronald V., Leonard, James N., Case, Martin A.

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Crystal Structure of the Tyrosine Kinase Domain of Colony-stimulating Factor-1 Receptor (cFMS) in Complex with Two Inhibitors von Schubert, Carsten, Schalk-Hihi, Céline, Struble, Geoffrey T., Ma, Hong-Chang, Petrounia, Ioanna P., Brandt, Benjamin, Deckman, Ingrid C., Patch, Raymond J., Player, Mark R., Spurlino, John C., Springer, Barry A.

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Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors von Wall, Mark J., Chen, Jinsheng, Meegalla, Sanath, Ballentine, Shelley K., Wilson, Kenneth J., DesJarlais, Renee L., Schubert, Carsten, Chaikin, Margery A., Crysler, Carl, Petrounia, Ioanna P., Donatelli, Robert R., Yurkow, Edward J., Boczon, Lisa, Mazzulla, Marie, Player, Mark R., Patch, Raymond J., Manthey, Carl L., Molloy, Christopher, Tomczuk, Bruce, Illig, Carl R.

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2-Hydroxy-4,6-diamino-[1,3,5]triazines: A Novel Class of VEGF-R2 (KDR) Tyrosine Kinase Inhibitors von Baindur, Nand, Chadha, Naresh, Brandt, Benjamin M, Asgari, Davoud, Patch, Raymond J, Schalk-HiHi, Celine, Carver, Theodore E, Petrounia, Ioanna P, Baumann, Christian A, Ott, Heidi, Manthey, Carl, Springer, Barry A, Player, Mark R

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Single-Step Syntheses of 2-Amino-7-chlorothiazolo[5,4-d]pyrimidines:  Intermediates for Bivalent Thiazolopyrimidines von Liu, Jian, Patch, Raymond J, Schubert, Carsten, Player, Mark R

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Potent 2′-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents von Patch, Raymond J., Brandt, Benjamin M., Asgari, Davoud, Baindur, Nand, Chadha, Naresh K., Georgiadis, Taxiarchis, Cheung, Wing S., Petrounia, Ioanna P., Donatelli, Robert R., Chaikin, Margery A., Player, Mark R.

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Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3 von Patch, Raymond J., Baumann, Christian A., Liu, Jian, Gibbs, Alan C., Ott, Heidi, Lattanze, Jennifer, Player, Mark R.

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Silver(II) oxide-mediated synthesis of 2,4-diarylquinazolines von Cheung, Wing, Patch, Raymond J., Player, Mark R.

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T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection von Clayton, Linda K., Ghendler, Yoseph, Mizoguchi, Emiko, Patch, Raymond J., Ocain, Timothy D., Orth, Kim, Bhan, Atul K., Dixit, Vishva M., Reinherz, Ellis L.

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Process Development for Scale-Up of a Novel 3,5-Substituted Thiazolidine-2,4-dione Compound as a Potent Inhibitor for Estrogen-Related Receptor 1 von Li, Xun, Russell, Ronald K, Spink, Jan, Ballentine, Scott, Teleha, Christopher, Branum, Shawn, Wells, Kenneth, Beauchamp, Derek, Patch, Raymond, Huang, Hui, Player, Mark, Murray, William

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Multivalent Templated Saccharides:  Convenient Syntheses of Spacer-Linked 1,1‘-Bis -and 1,1‘,1‘‘-Tris-β-glycosides by the Glycal Epoxide Glycosidation Method von Patch, Raymond J, Chen, Hang, Pandit, Chennagiri R

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Asymmetric synthesis of a potent and selective competitive NMDA antagonist von Hamilton, Gregory S, Huang, Zhiwen, Yang, Xiao Jing, Patch, Raymond J, Narayanan, B. A, Ferkany, John W

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(Aminoalkoxy)chromones. Selective .sigma. receptor ligands von Erickson, Ronald H, Natalie, Kenneth J, Bock, William, Lu, Zhijian, Farzin, Farzaneh, Sherrill, Ronald G, Meloni, David J, Patch, Raymond J, Rzesotarski, Waclaw J

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Possible cerebroprotective and in vivo NMDA antagonist activities of sigma agents von Pontecorvo, Michael J., Karbon, E.William, Goode, Stacey, Clissold, David B., Borosky, Susan A., Patch, Raymond J., Ferkany, John W.

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