Predicting Circulating Human Metabolites: How Good Are We? von Anderson, Shelby, Luffer-Atlas, Debra, Knadler, Mary Pat

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Development and validation of a liquid chromatography—tandem mass spectrometric method for the determination of the major metabolites of duloxetine in human plasma von Satonin, Darlene K., McCulloch, Julie D., Kuo, Fengjiun, Knadler, Mary Pat

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Population Pharmacokinetics of Orally Administered Duloxetine in Patients: Implications for Dosing Recommendation von Lobo, Evelyn D., Quinlan, Tonya, O’Brien, Lisa, Knadler, Mary Pat, Heathman, Michael

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Effects of Varying Degrees of Renal Impairment on the Pharmacokinetics of Duloxetine: Analysis of a Single-Dose Phase I Study and Pooled Steady-State Data from Phase II/III Trials von Lobo, Evelyn D., Heathman, Michael, Kuan, Han-Yi, Reddy, Shobha, O’Brien, Lisa, Gonzales, Celedon, Skinner, Michael, Knadler, Mary Pat

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Duloxetine: Clinical Pharmacokinetics and Drug Interactions von Knadler, Mary Pat, Lobo, Evelyn, Chappell, Jill, Bergstrom, Richard

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Pharmacokinetics and tolerability of duloxetine following oral administration to healthy chinese subjects von TIANMEI, Si, PAT KNADLER, Mary, LIM, Ming T, KWEE POO YEO, LEYAN TENG, SHU LIANG, PAN, Alan X, LOBO, Evelyn D

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Raloxifene reduces atherosclerosis: studies of optimized raloxifene doses in ovariectomized, cholesterol-fed rabbits von Bjarnason, Nina Hannover, Haarbo, Jens, Byrjalsen, Inger, Kauffman, Raymond F., Knadler, Mary Pat, Christiansen, Claus

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Basal Insulin Peglispro Demonstrates Preferential Hepatic Versus Peripheral Action Relative to Insulin Glargine in Healthy Subjects von HENRY, Robert R, MUDALIAR, Sunder, CHEN QUIN LAM, Eric, PRINCE, Melvin J, BOSE, Namrata, PORKSEN, Niels, SINHA, Vikram P, LINNEBJERG, Helle, CIARALDI, Theodore P, ARMSTRONG, Debra A, BURKE, Paivi, PETTUS, Jeremy, GARHYAN, Parag, SIAK LENG CHOI, JACOBER, Scott J, KNADLER, Mary Pat

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Chronic Toxicology Studies of Basal Insulin Peglispro in Rats and Dogs: A Novel, PEGylated Insulin Lispro Analog with a Prolonged Duration of Action von Byrd, Richard A., Blackbourne, Jamie L., Knadler, Mary Pat, Schultze, Albert E., Vahle, John L.

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In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1 von Pak, Y. Anne, Long, Amanda J., Annes, William F., Witcher, Jennifer W., Knadler, Mary Pat, Ayan-Oshodi, Mosun A., Mitchell, Malcolm I., Leese, Phillip, Hillgren, Kathleen M.

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Addition of 20-kDa PEG to Insulin Lispro Alters Absorption and Decreases Clearance in Animals von Knadler, Mary Pat, Nguyen, Tri-Hung, Campanale, Kristina, De Veer, Michael J., Beals, John M., Li, Shun, Hansen, Ryan, Siesky, Angela, Michael, M. Dodson, Porter, Christopher J. H.

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Disposition of Basal Insulin Peglispro Compared with 20-kDa Polyethylene Glycol in Rats Following a Single Intravenous or Subcutaneous Dose von Knadler, Mary Pat, Ellis, Bernice B, Brown-Augsburger, Patricia L, Murphy, Anthony T, Martin, Jennifer A, Wroblewski, Victor J

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In Vitro and In Vivo Evaluations of Cytochrome P450 1A2 Interactions with Duloxetine von Lobo, Evelyn D., Bergstrom, Richard F., Reddy, Shobha, Quinlan, Tonya, Chappell, Jill, Hong, Quan, Ring, Barbara, Knadler, Mary Pat

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Quantification of Basal Insulin Peglispro and Human Insulin in Adipose Tissue Interstitial Fluid by Open-Flow Microperfusion von Tiffner, Katrin, Boulgaropoulos, Beate, Höfferer, Christian, Birngruber, Thomas, Porksen, Niels, Linnebjerg, Helle, Garhyan, Parag, Lam, Eric Chen Quin, Knadler, Mary Pat, Pieber, Thomas R, Sinner, Frank

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Relative Contributions of Presystemic and Systemic Peptidases to Oral Exposure of a Novel Metabotropic Glutamate 2/3 Receptor Agonist (LY404039) After Oral Administration of Prodru... von Annes, William F., Long, Amanda, Witcher, Jennifer W., Ayan-Oshodi, Mosun A., Knadler, Mary Pat, Zhang, Wei, Mitchell, Malcolm I., Cornelissen, Karen, Hall, Stephen D.

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Duloxetine von Knadler, Mary Pat, Lobo, Evelyn, Chappell, Jill, Bergstrom, Richard

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Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers von Skinner, Michael H., Kuan, Han‐Yi, Pan, Alan, Sathirakul, Korbtham, Knadler, Mary Pat, Gonzales, Celedon R., Yeo, Kwee Poo, Reddy, Shobha, Lim, Maggie, Ayan‐Oshodi, Mosun, Wise, Stephen D.

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Clinical Pharmacokinetics and Drug Interactions von PAT KNADLER, Mary, LOBO, Evelyn, CHAPPELL, Jill, BERGSTROM, Richard

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Effects of Duloxetine on the Pharmacodynamics and Pharmacokinetics of Warfarin at Steady State in Healthy Subjects von Chappell, Jill, He, Jingsong, Knadler, Mary Pat, Mitchell, Malcolm, Lee, Douglas, Lobo, Evelyn

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Effect of pomaglumetad methionil on the QT interval in subjects with schizophrenia von Zhang, Wei, Mitchell, Malcolm I, Knadler, Mary Pat, Long, Amanda, Witcher, Jennifer, Walling, David, Annes, William, Ayan-Oshodi, Mosun

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