The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma von Bhaskaran, Vivek, Nowicki, Michal O., Idriss, Mahmoud, Jimenez, Miguel A., Lugli, Gianmarco, Hayes, Josie L., Mahmoud, Ahmad Bakur, Zane, Rachel E., Passaro, Carmela, Ligon, Keith L., Haas-Kogan, Daphne, Bronisz, Agnieszka, Godlewski, Jakub, Lawler, Sean E., Chiocca, E. Antonio, Peruzzi, Pierpaolo

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Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma von Nakashima, Hiroshi, Nguyen, Tran, Kasai, Kazue, Passaro, Carmela, Ito, Hirotaka, Goins, William F, Shaikh, Imran, Erdelyi, Ronald, Nishihara, Reiko, Nakano, Ichiro, Reardon, David A, Anderson, Ana C, Kuchroo, Vijay, Chiocca, E Antonio

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Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus von Mineo, Marco, Lyons, Shawn M., Zdioruk, Mykola, von Spreckelsen, Niklas, Ferrer-Luna, Ruben, Ito, Hirotaka, Alayo, Quazim A., Kharel, Prakash, Giantini Larsen, Alexandra, Fan, William Y., Auduong, Sophia, Grauwet, Korneel, Passaro, Carmela, Khalsa, Jasneet K., Shah, Khalid, Reardon, David A., Ligon, Keith L., Beroukhim, Rameen, Nakashima, Hiroshi, Ivanov, Pavel, Anderson, Paul J., Lawler, Sean E., Chiocca, E. Antonio

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Glioblastoma infiltration of both tumor- and virus-antigen specific cytotoxic T cells correlates with experimental virotherapy responses von Alayo, Quazim A., Ito, Hirotaka, Passaro, Carmela, Zdioruk, Mykola, Mahmoud, Ahmad Bakur, Grauwet, Korneel, Zhang, Xiaoli, Lawler, Sean E., Reardon, David A., Goins, William F., Fernandez, Soledad, Chiocca, E. Antonio, Nakashima, Hiroshi

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Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma von Speranza, Maria-Carmela, Passaro, Carmela, Ricklefs, Franz, Kasai, Kazue, Klein, Sarah R, Nakashima, Hiroshi, Kaufmann, Johanna K, Ahmed, Abdul-Kareem, Nowicki, Michal O, Obi, Prisca, Bronisz, Agnieszka, Aguilar-Cordova, Estuardo, Aguilar, Laura K, Guzik, Brian W, Breakefield, Xandra, Weissleder, Ralph, Freeman, Gordon J, Reardon, David A, Wen, Patrick Y, Chiocca, E Antonio, Lawler, Sean E

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The Oncolytic Virus dl922-947 Triggers Immunogenic Cell Death in Mesothelioma and Reduces Xenograft Growth von Di Somma, Sarah, Iannuzzi, Carmelina Antonella, Passaro, Carmela, Forte, Iris Maria, Iannone, Raffaella, Gigantino, Vincenzo, Indovina, Paola, Botti, Gerardo, Giordano, Antonio, Formisano, Pietro, Portella, Giuseppe, Malfitano, Anna Maria, Pentimalli, Francesca

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PARP inhibitor olaparib increases the oncolytic activity of dl922-947 in in vitro and in vivo model of anaplastic thyroid carcinoma von Passaro, Carmela, Volpe, Massimiliano, Botta, Ginevra, Scamardella, Eloise, Perruolo, Giuseppe, Gillespie, David, Libertini, Silvana, Portella, Giuseppe

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AZD1152 negatively affects the growth of anaplastic thyroid carcinoma cells and enhances the effects of oncolytic virus dl922-947 von Libertini, Silvana, Abagnale, Antonella, Passaro, Carmela, Botta, Ginevra, Barbato, Sara, Chieffi, Paolo, Portella, Giuseppe

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Ionizing radiation enhances dl922–947-mediated cell death of anaplastic thyroid carcinoma cells von Passaro, Carmela, Abagnale, Antonella, Libertini, Silvana, Volpe, Massimiliano, Botta, Ginevra, Cella, Laura, Pacelli, Roberto, Halldèn, Gunnel, Gillespie, David, Portella, Giuseppe

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Oncolytic virotherapy for anaplastic and poorly differentiated thyroid cancer: a promise or a clinical reality? von Passaro, Carmela, Somma, Sarah Di, Malfitano, Anna Maria, Portella, Giuseppe

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Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy von Passaro, Carmela, Alayo, Quazim, De Laura, Isabella, McNulty, John, Grauwet, Korneel, Ito, Hirotaka, Bhaskaran, Vivek, Mineo, Marco, Lawler, Sean E, Shah, Khalid, Speranza, Maria C, Goins, William, McLaughlin, Eric, Fernandez, Soledad, Reardon, David A, Freeman, Gordon J, Chiocca, E Antonio, Nakashima, Hiroshi

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Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles von Ricklefs, Franz L, Alayo, Quazim, Krenzlin, Harald, Mahmoud, Ahmad B, Speranza, Maria C, Nakashima, Hiroshi, Hayes, Josie L, Lee, Kyungheon, Balaj, Leonora, Passaro, Carmela, Rooj, Arun K, Krasemann, Susanne, Carter, Bob S, Chen, Clark C, Steed, Tyler, Treiber, Jeffrey, Rodig, Scott, Yang, Katherine, Nakano, Ichiro, Lee, Hakho, Weissleder, Ralph, Breakefield, Xandra O, Godlewski, Jakub, Westphal, Manfred, Lamszus, Katrin, Freeman, Gordon J, Bronisz, Agnieszka, Lawler, Sean E, Chiocca, E Antonio

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The oncolytic virus dl922-947 reduces IL-8/CXCL8 and MCP-1/CCL2 expression and impairs angiogenesis and macrophage infiltration in anaplastic thyroid carcinoma von Passaro, Carmela, Borriello, Francesco, Vastolo, Viviana, Di Somma, Sarah, Scamardella, Eloise, Gigantino, Vincenzo, Franco, Renato, Marone, Gianni, Portella, Giuseppe

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High Levels of Gpr30 Protein in Human Testicular Carcinoma In Situ and Seminomas Correlate with Low Levels of Estrogen Receptor-Beta and Indicate a Switch in Estrogen Responsivenes... von Boscia, Francesca, Passaro, Carmela, Gigantino, Vincenzo, Perdonà, Sisto, Franco, Renato, Portella, Giuseppe, Chieffi, Sergio, Chieffi, Paolo

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Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis von Krenzlin, Harald, Behera, Prajna, Lorenz, Viola, Passaro, Carmela, Zdioruk, Mykola, Nowicki, Michal O, Grauwet, Korneel, Zhang, Hong, Skubal, Magdalena, Ito, Hirotaka, Zane, Rachel, Gutknecht, Michael, Griessl, Marion B, Ricklefs, Franz, Ding, Lai, Peled, Sharon, Rooj, Arun, James, C David, Cobbs, Charles S, Cook, Charles H, Chiocca, E Antonio, Lawler, Sean E

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IMMU-05. IMMUNE STIMULATION AND IMMUNE CHECKPOINT INHIBITION PROVIDED BY A SINGLE AGENT: AN ONCOLYTIC HSV EXPRESSING A scFv ANTIBODY AGAINST PD-1 von Passaro, Carmela, Alayo, Quazim, Nakashima, Hiroshi, Chiocca, E Antonio

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Glucose impairs tamoxifen responsiveness modulating connective tissue growth factor in breast cancer cells von Ambrosio, Maria Rosaria, D'Esposito, Vittoria, Costa, Valerio, Liguoro, Domenico, Collina, Francesca, Cantile, Monica, Prevete, Nella, Passaro, Carmela, Mosca, Giusy, De Laurentiis, Michelino, Di Bonito, Maurizio, Botti, Gerardo, Franco, Renato, Beguinot, Francesco, Ciccodicola, Alfredo, Formisano, Pietro

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IMMU-02. ONCOLYTIC HSV THERAPY ENHANCES GLIOBLASTOMA CONTROL VIA THE EXPANSION OF FUNCTIONAL TUMOR-SPECIFIC T CELLS AND MODULATION OF MYELOID CELL POPULATION von Alayo, Quazim, Ito, Hirotaka, Passaro, Carmela, Zdioruk, Mykola, Mahmoud, Ahmad, Nakashima, Hiroshi, Chiocca, E Antonio

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Abstract 5009: Translational efficacy of oncolytic HSV-1 in glioblastoma using a human autologous ex vivo platform, CANscript von Smalley, Munisha, Kapoor, Vidushi, Best, Douglas, Passaro, Carmela, Nowicki, Michal O., Saha, Suniti K., Prasad, Komal, Chiocca, E. Antonio, Lawler, Sean E., Goldman, Aaron

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Oncolytic Virus Therapy Alters the Secretome of Targeted Glioblastoma Cells von Godlewski, Jakub, Farhath, Mohamed, Ricklefs, Franz L, Passaro, Carmela, Kiel, Klaudia, Nakashima, Hiroshi, Chiocca, E Antonio, Bronisz, Agnieszka

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