Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014 von Pike, Kurt G., Malagu, Karine, Hummersone, Marc G., Menear, Keith A., Duggan, Heather M.E., Gomez, Sylvie, Martin, Niall M.B., Ruston, Linette, Pass, Sarah L., Pass, Martin

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Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically von Riches, Lucy C., Trinidad, Antonio G., Hughes, Gareth, Jones, Gemma N., Hughes, Adina M., Thomason, Andrew G., Gavine, Paul, Cui, Andy, Ling, Stephanie, Stott, Jonathan, Clark, Roger, Peel, Samantha, Gill, Pendeep, Goodwin, Louise M., Smith, Aaron, Pike, Kurt G., Barlaam, Bernard, Pass, Martin, O'Connor, Mark J., Smith, Graeme, Cadogan, Elaine B.

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The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyr... von Pike, Kurt G, Barlaam, Bernard, Cadogan, Elaine, Campbell, Andrew, Chen, Yingxue, Colclough, Nicola, Davies, Nichola L, de-Almeida, Camila, Degorce, Sebastien L, Didelot, Myriam, Dishington, Allan, Ducray, Richard, Durant, Stephen T, Hassall, Lorraine A, Holmes, Jane, Hughes, Gareth D, MacFaul, Philip A, Mulholland, Keith R, McGuire, Thomas M, Ouvry, Gilles, Pass, Martin, Robb, Graeme, Stratton, Natalie, Wang, Zhenhua, Wilson, Joanne, Zhai, Baochang, Zhao, Kang, Al-Huniti, Nidal

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A Phase I Open-Label Study to Identify a Dosing Regimen of the Pan-AKT Inhibitor AZD5363 for Evaluation in Solid Tumors and in PIK3CA -Mutated Breast and Gynecologic Cancers von Banerji, Udai, Dean, Emma J, Pérez-Fidalgo, J Alejandro, Batist, Gerald, Bedard, Philippe L, You, Benoit, Westin, Shannon N, Kabos, Peter, Garrett, Michelle D, Tall, Mathew, Ambrose, Helen, Barrett, J Carl, Carr, T Hedley, Cheung, S Y Amy, Corcoran, Claire, Cullberg, Marie, Davies, Barry R, de Bruin, Elza C, Elvin, Paul, Foxley, Andrew, Lawrence, Peter, Lindemann, Justin P O, Maudsley, Rhiannon, Pass, Martin, Rowlands, Vicky, Rugman, Paul, Schiavon, Gaia, Yates, James, Schellens, Jan H M

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AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules von Guichard, Sylvie M, Curwen, Jon, Bihani, Teeru, D'Cruz, Celina M, Yates, James W T, Grondine, Michael, Howard, Zoe, Davies, Barry R, Bigley, Graham, Klinowska, Teresa, Pike, Kurt G, Pass, Martin, Chresta, Christine M, Polanska, Urszula M, McEwen, Robert, Delpuech, Oona, Green, Stephen, Cosulich, Sabina C

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Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors von Anderton, Mark J., Mellor, Howard R., Bell, Alex, Sadler, Claire, Pass, Martin, Powell, Steve, Steele, Samantha J., Roberts, Ruth. R. A., Heier, Annabelle

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Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by Structure-Based Design and Optimization of Thiophene... von Oza, Vibha, Ashwell, Susan, Almeida, Lynsie, Brassil, Patrick, Breed, Jason, Deng, Chun, Gero, Thomas, Grondine, Michael, Horn, Candice, Ioannidis, Stephanos, Liu, Dongfang, Lyne, Paul, Newcombe, Nicholas, Pass, Martin, Read, Jon, Ready, Shannon, Rowsell, Siân, Su, Mei, Toader, Dorin, Vasbinder, Melissa, Yu, Dingwei, Yu, Yan, Xue, Yafeng, Zabludoff, Sonya, Janetka, James

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Diverse Heterocyclic Scaffolds as Allosteric Inhibitors of AKT von Kettle, Jason G, Brown, Simon, Crafter, Claire, Davies, Barry R, Dudley, Phillippa, Fairley, Gary, Faulder, Paul, Fillery, Shaun, Greenwood, Hannah, Hawkins, Janet, James, Michael, Johnson, Keith, Lane, Clare D, Pass, Martin, Pink, Jennifer H, Plant, Helen, Cosulich, Sabina C

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Abstract 3343: The pre-clinical in vitro and in vivo activity of AZD6738: A potent and selective inhibitor of ATR kinase von Guichard, Sylvie M., Brown, Elaine, Odedra, Rajesh, Hughes, Adina, Heathcote, Dan, Barnes, Jen, Lau, Alan, Powell, Steve, Jones, Clifford D., Nissink, Willem, Foote, Kevin M., Jewsbury, Philip J., Pass, Martin

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Discovery of a novel class of triazolones as Checkpoint Kinase inhibitors—Hit to lead exploration von Oza, Vibha, Ashwell, Susan, Brassil, Patrick, Breed, Jason, Deng, Chun, Ezhuthachan, Jay, Haye, Heather, Horn, Candice, Janetka, James, Lyne, Paul, Newcombe, Nicholas, Otterbien, Ludo, Pass, Martin, Read, Jon, Roswell, Sian, Su, Mei, Toader, Dorin, Yu, Dingwei, Yu, Yan, Valentine, Anna, Webborn, Peter, White, Ann, Zabludoff, Sonya, Zheng, Xiaolan

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Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors von Janetka, James W., Almeida, Lynsie, Ashwell, Susan, Brassil, Patrick J., Daly, Kevin, Deng, Chun, Gero, Thomas, Glynn, Roberta E., Horn, Candice L., Ioannidis, Stephanos, Lyne, Paul, Newcombe, Nicholas J., Oza, Vibha B., Pass, Martin, Springer, Stephanie K., Su, Mei, Toader, Dorin, Vasbinder, Melissa M., Yu, Dingwei, Yu, Yan, Zabludoff, Sonya D.

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AKT Inhibition in Solid Tumors With AKT1 Mutations von Hyman, David M, Smyth, Lillian M, Donoghue, Mark T A, Westin, Shannon N, Bedard, Philippe L, Dean, Emma J, Bando, Hideaki, El-Khoueiry, Anthony B, Pérez-Fidalgo, José A, Mita, Alain, Schellens, Jan H M, Chang, Matthew T, Reichel, Jonathan B, Bouvier, Nancy, Selcuklu, S Duygu, Soumerai, Tara E, Torrisi, Jean, Erinjeri, Joseph P, Ambrose, Helen, Barrett, J Carl, Dougherty, Brian, Foxley, Andrew, Lindemann, Justin P O, McEwen, Robert, Pass, Martin, Schiavon, Gaia, Berger, Michael F, Chandarlapaty, Sarat, Solit, David B, Banerji, Udai, Baselga, José, Taylor, Barry S

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Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background von Davies, Barry R, Greenwood, Hannah, Dudley, Phillippa, Crafter, Claire, Yu, De-Hua, Zhang, Jingchuan, Li, Jing, Gao, Beirong, Ji, Qunsheng, Maynard, Juliana, Ricketts, Sally-Ann, Cross, Darren, Cosulich, Sabina, Chresta, Christine C, Page, Ken, Yates, James, Lane, Clare, Watson, Rebecca, Luke, Richard, Ogilvie, Donald, Pass, Martin

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Capivasertib, an AKT Kinase Inhibitor, as Monotherapy or in Combination with Fulvestrant in Patients with AKT1(E17K)-Mutant, ER-Positive Metastatic Breast Cancer von Smyth, Lillian M., Tamura, Kenji, Oliveira, Mafalda, Ciruelos, Eva M., Mayer, Ingrid A., Sablin, Marie-Paule, Biganzoli, Laura, Ambrose, Helen J., Ashton, Jack, Barnicle, Alan, Cashell, Des D., Corcoran, Claire, de Bruin, Elza C., Foxley, Andrew, Hauser, Joana, Lindemann, Justin P. O., Maudsley, Rhiannon, McEwen, Robert, Moschetta, Michele, Pass, Martin, Rowlands, Vicky, Schiavon, Gaia, Banerji, Udai, Scaltriti, Maurizio, Taylor, Barry S., Chandarlapaty, Sarat, Baselga, Jose, Hyman, David M.

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AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity von CHRESTA, Christine M, DAVIES, Barry R, JAMES, Dominic, HOWARD, Zoe, DUDLEY, Phillippa, HUGHES, Gareth, SMITH, Lisa, MAGUIRE, Sharon, HUMMERSONE, Marc, MALAGU, Karine, MENEAR, Keith, JENKINS, Richard, HICKSON, Ian, JACOBSEN, Matt, SMITH, Graeme C. M, GUICHARD, Sylvie, PASS, Martin, HARDING, Tom, COSULICH, Sabina, CRITCHLOW, Susan E, VINCENT, John P, ELLSTON, Rebecca, JONES, Darren, SINI, Patrizia

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Brain exposure of the ATM inhibitor AZD1390 in humans-a positron emission tomography study von Jucaite, Aurelija, Stenkrona, Per, Cselenyi, Zsolt, De Vita, Serena, Buil-Bruna, Nuria, Varnas, Katarina, Savage, Alicia, Varrone, Andrea, Johnstrom, Peter, Schou, Magnus, Davison, Chris, Sykes, Andy, Reddy, Venkatesh Pilla, Hoch, Matthias, Vazquez-Romero, Ana, Moein, Mohammad Mahdi, Halldin, Christer, Merchant, Melinda S., Pass, Martin, Farde, Lars

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Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood–Brain Barrier: The Discovery of AZD1390 von Pike, Kurt G., Hunt, Thomas A., Barlaam, Bernard, Benstead, David, Cadogan, Elaine, Chen, Kan, Cook, Calum R., Colclough, Nicola, Deng, Chao, Durant, Stephen T., Eatherton, Andrew, Goldberg, Kristin, Johnström, Peter, Liu, Libin, Liu, Zhaoqun, Nissink, J. Willem M., Pang, Chengling, Pass, Martin, Robb, Graeme R., Roberts, Caroline, Schou, Magnus, Steward, Oliver, Sykes, Andy, Yan, Yumei, Zhai, Baochang, Zheng, Li

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The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models von Durant, Stephen T, Zheng, Li, Wang, Yingchun, Chen, Kan, Zhang, Lingli, Zhang, Tianwei, Yang, Zhenfan, Riches, Lucy, Trinidad, Antonio G, Fok, Jacqueline H L, Hunt, Tom, Pike, Kurt G, Wilson, Joanne, Smith, Aaron, Colclough, Nicola, Reddy, Venkatesh Pilla, Sykes, Andrew, Janefeldt, Annika, Johnström, Peter, Varnäs, Katarina, Takano, Akihiro, Ling, Stephanie, Orme, Jonathan, Stott, Jonathan, Roberts, Caroline, Barrett, Ian, Jones, Gemma, Roudier, Martine, Pierce, Andrew, Allen, Jasmine, Kahn, Jenna, Sule, Amrita, Karlin, Jeremy, Cronin, Anna, Chapman, Melissa, Valerie, Kristoffer, Illingworth, Ruth, Pass, Martin

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Proliferation and AKT Activity Biomarker Analyses after Capivasertib (AZD5363) Treatment of Patients with ER+ Invasive Breast Cancer (STAKT) von Robertson, John F. R., Coleman, Robert E., Cheung, Kwok-Leung, Evans, Abigail, Holcombe, Chris, Skene, Anthony, Rea, Daniel, Ahmed, Samreen, Jahan, Ali, Horgan, Kieran, Rauchhaus, Petra, Littleford, Roberta, Cheung, S. Y. Amy, Cullberg, Marie, de Bruin, Elza C., Koulai, Loumpiana, Lindemann, Justin P. O., Pass, Martin, Rugman, Paul, Schiavon, Gaia, Deb, Rahul, Finlay, Pauline, Foxley, Andrew, Gee, Julia M. W.

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Abstract 4909: Adaptive oncology phase 1 study of first-in-class inhibitor of ataxia telangiectasia mutated protein kinase (ATM), in combination with olaparib von Chen, Yingxue, Pass, Martin, Bruna, Nuria Bui, Stephens, Christine, Pierce, Andrew, Hanekom, Wouter, Gabra, Hani, Tomkinson, Helen, Al-Huniti, Nidal

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