Strategic studies in the syntheses of novel 6,7-substituted quinolones and 7- or 6-substituted 1,6- and 1,7-naphthyridones von Morgentin, Rémy, Pasquet, Georges, Boutron, Pascal, Jung, Frédéric, Lamorlette, Maryannick, Maudet, Mickaël, Plé, Patrick

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Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase von Mortlock, Andrew A, Foote, Kevin M, Heron, Nicola M, Jung, Frédéric H, Pasquet, Georges, Lohmann, Jean-Jacques M, Warin, Nicolas, Renaud, Fabrice, De Savi, Chris, Roberts, Nicola J, Johnson, Trevor, Dousson, Cyril B, Hill, George B, Perkins, David, Hatter, Glenn, Wilkinson, Robert W, Wedge, Stephen R, Heaton, Simon P, Odedra, Rajesh, Keen, Nicholas J, Crafter, Claire, Brown, Elaine, Thompson, Katherine, Brightwell, Stephen, Khatri, Liz, Brady, Madeleine C, Kearney, Sarah, McKillop, David, Rhead, Steve, Parry, Tony, Green, Stephen

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Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective... von Barlaam, Bernard, Cosulich, Sabina, Delouvrié, Bénédicte, Ellston, Rebecca, Fitzek, Martina, Germain, Hervé, Green, Stephen, Hancox, Urs, Harris, Craig S., Hudson, Kevin, Lambert-van der Brempt, Christine, Lebraud, Honorine, Magnien, Françoise, Lamorlette, Maryannick, Le Griffon, Antoine, Morgentin, Rémy, Ouvry, Gilles, Page, Ken, Pasquet, Georges, Polanska, Urszula, Ruston, Linette, Saleh, Twana, Vautier, Michel, Ward, Lara

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Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases von Plé, Patrick A., Jung, Frédéric, Ashton, Sue, Hennequin, Laurent, Laine, Romuald, Morgentin, Rémy, Pasquet, Georges, Taylor, Sian

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Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors von Jung, Frédéric H, Pasquet, Georges, Lambert-van der Brempt, Christine, Lohmann, Jean-Jacques M, Warin, Nicolas, Renaud, Fabrice, Germain, Hervé, De Savi, Chris, Roberts, Nicola, Johnson, Trevor, Dousson, Cyril, Hill, George B, Mortlock, Andrew A, Heron, Nicola, Wilkinson, Robert W, Wedge, Stephen R, Heaton, Simon P, Odedra, Rajesh, Keen, Nicholas J, Green, Stephen, Brown, Elaine, Thompson, Katherine, Brightwell, Stephen

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Abstract 2830: Discovery of AZD8835, a potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of PIK3CA -dependent cancers von Barlaam, Bernard, Cosulich, Sabina, Delouvrie, Benedicte, Fitzek, Martina, Germain, Herve, Green, Stephen, Harris, Craig S., Hudson, Kevin, Lambert-van der Brempt, Christine, Lamorlette, Maryannick, Antoine, Le Griffon, Morgentin, Remy, Ouvry, Gilles, Page, Ken, Pasquet, Georges, Ruston, Linette, Saleh, Twana, Vautier, Michel, Ward, Lara

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Facile preparation of thiophene C2-ethers using the Mitsunobu reaction von Harris, Craig S., Germain, Hervé, Pasquet, Georges

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An efficient large-scale synthesis of alkyl 5-hydroxy-pyridin- and pyrimidin-2-yl acetate von Morgentin, Rémy, Jung, Frédéric, Lamorlette, Maryannick, Maudet, Mickaël, Ménard, Morgan, Plé, Patrick, Pasquet, Georges, Renaud, Fabrice

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A versatile route to 3-(pyrimidin-4-yl)-imidazo[1,2- a]pyridines and 3-(pyrimidin-4-yl)-pyrazolo[1,5- a]pyridines von Ducray, Richard, Boutron, Pascal, Didelot, Myriam, Germain, Hervé, Lach, Franck, Lamorlette, Maryannick, Legriffon, Antoine, Maudet, Mickael, Ménard, Morgan, Pasquet, Georges, Renaud, Fabrice, Simpson, Iain, Young, Gail L.

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Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases von Plé, Patrick A., Jung, Frédéric, Ashton, Sue, Hennequin, Laurent, Laine, Romuald, Lambert-van der Brempt, Christine, Morgentin, Rémy, Pasquet, Georges, Taylor, Sian

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Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: Selective inhibitors of Aurora B kinase with potent anti-tumor activity von Foote, Kevin M., Mortlock, Andrew A., Heron, Nicola M., Jung, Frédéric H., Hill, George B., Pasquet, Georges, Brady, Madeleine C., Green, Stephen, Heaton, Simon P., Kearney, Sarah, Keen, Nicholas J., Odedra, Rajesh, Wedge, Stephen R., Wilkinson, Robert W.

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An efficient large-scale synthesis of alkyl 5-hydroxy-pyridinand pyrimidin-2-yl acetate von MORGENTIN, Rémy, JUNG, Frédéric, LAMORLETTE, Maryannick, MAUDET, Mickaël, MENARD, Morgan, PLE, Patrick, PASQUET, Georges, RENAUD, Fabrice

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Synthesis of (±)-negamycin and of (±)-epinegamycin von Pasquet, Georges, Boucherot, Dominique, Pilgrim, William R., Wright, Brian

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Methods of treatment using N-(3-fluorophenyl)-2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}-quinazolin-4-yl)amino]-1H-pyrazol-5-yl}acetamide von Mortlock Andrew, Pasquet Georges, Jung Frederic Henri, Heron Nicola Murdoch

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SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF AURORA KINASES von JUNG, FREDERIC HENRI, PASQUET, GEORGES RENE

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ChemInform Abstract: Synthesis and Functionalization of 4-Substituted Quinazolines as Kinase Templates von Harris, Craig S., Hennequin, Laurent, Morgentin, Remy, Pasquet, Georges

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CHEMICAL COMPOUNDS von MORTLOCK ANDREW, HERON NICOLA MURDOCH, JUNG FREDERIC HENRI, PASQUET GEORGES

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ChemInform Abstract: Facile Preparation of Thiophene C2-Ethers Using the Mitsunobu Reaction von Harris, Craig S., Germain, Herve, Pasquet, Georges

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Derivatives of phosphonooxyquinazoline their compositions and pharmaceutical application von PASQUET GEORGES RENE, JUNG FREDERIC HENRI, MORTLOCK ANDREW AUSTEN, MURDOCH HERON NICOLA

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SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF AURORA KINASES von PASQUET GEORGES RENE, JUNG FREDERIC HENRI

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