Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition von Bledsoe, Randy K., Montana, Valerie G., Stanley, Thomas B., Delves, Chris J., Apolito, Christopher J., McKee, David D., Consler, Thomas G., Parks, Derek J., Stewart, Eugene L., Willson, Timothy M., Lambert, Millard H., Moore, John T., Pearce, Kenneth H., Xu, H.Eric

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Identification of a Novel Human Constitutive Androstane Receptor (CAR) Agonist and Its Use in the Identification of CAR Target Genes von Maglich, Jodi M., Parks, Derek J., Moore, Linda B., Collins, Jon L., Goodwin, Bryan, Billin, Andrew N., Stoltz, Catherine A., Kliewer, Steven A., Lambert, Millard H., Willson, Timothy M., Moore, John T.

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Bile Acids: Natural Ligands for an Orphan Nuclear Receptor von Parks, Derek J., Blanchard, Steven G., Bledsoe, Randy K., Chandra, Gyan, Consler, Thomas G., Kliewer, Steven A., Stimmel, Julie B., Willson, Timothy M., Zavacki, Ann Marie, Moore, David D., Lehmann, Jürgen M.

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Functional Consequences of Cysteine Modification in the Ligand Binding Sites of Peroxisome Proliferator Activated Receptors by GW9662 von Leesnitzer, Lisa M, Parks, Derek J, Bledsoe, Randy K, Cobb, Jeff E, Collins, Jon L, Consler, Thomas G, Davis, Roderick G, Hull-Ryde, Emily A, Lenhard, James M, Patel, Lisa, Plunket, Kelli D, Shenk, Jennifer L, Stimmel, Julie B, Therapontos, Christina, Willson, Timothy M, Blanchard, Steven G

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Novel heterocyclic scaffolds of GW4064 as farnesoid X receptor agonists von Smalley, Jr, Terrence L, Boggs, Sharon, Caravella, Justin A, Chen, Lihong, Creech, Katrina L, Deaton, David N, Kaldor, Istvan, Parks, Derek J

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Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064 von Akwabi-Ameyaw, Adwoa, Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Jones, Stacey A., Kaldor, Istvan, Liu, Yaping, Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., III, Frank Navas, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce

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Identification of a Nonsteroidal Liver X Receptor Agonist through Parallel Array Synthesis of Tertiary Amines von Collins, Jon L, Fivush, Adam M, Watson, Michael A, Galardi, Cristin M, Lewis, Michael C, Moore, Linda B, Parks, Derek J, Wilson, Joan G, Tippin, Tim K, Binz, Jane G, Plunket, Kelli D, Morgan, Daniel G, Beaudet, Elizabeth J, Whitney, Karl D, Kliewer, Steven A, Willson, Timothy M

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Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors von Xu, H.Eric, Lambert, Millard H, Montana, Valerie G, Parks, Derek J, Blanchard, Steven G, Brown, Peter J, Sternbach, Daniel D, Lehmann, Jürgen M, Wisely, G.Bruce, Willson, Timothy M, Kliewer, Steven A, Milburn, Michael V

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The Phytoestrogen Coumestrol Is a Naturally Occurring Antagonist of the Human Pregnane X Receptor von Wang, Hongwei, Li, Hao, Moore, Linda B, Johnson, Michael D. L, Maglich, Jodi M, Goodwin, Bryan, Ittoop, Olivia R. R, Wisely, Bruce, Creech, Katrina, Parks, Derek J, Collins, Jon L, Willson, Timothy M, Kalpana, Ganjam V, Venkatesh, Madhukumar, Xie, Wen, Cho, Sool Y, Roboz, John, Redinbo, Matthew, Moore, John T, Mani, Sridhar

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Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR von Maloney, Patrick R, Parks, Derek J, Haffner, Curt D, Fivush, Adam M, Chandra, Gyan, Plunket, Kelli D, Creech, Katrina L, Moore, Linda B, Wilson, Joan G, Lewis, Michael C, Jones, Stacey A, Willson, Timothy M

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Identification of Small Molecule Agonists of the Orphan Nuclear Receptors Liver Receptor Homolog-1 and Steroidogenic Factor-1 von Whitby, Richard J, Dixon, Sally, Maloney, Patrick R, Delerive, Philippe, Goodwin, Bryan J, Parks, Derek J, Willson, Timothy M

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Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene von Bass, Jonathan Y., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Mills, Wendy Y., Navas, Frank, Parks, Derek J., Smalley, Terrence L., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce

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FXR agonist activity of conformationally constrained analogs of GW 4064 von Akwabi-Ameyaw, Adwoa, Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Navas, Frank, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Bruce Wisely, G.

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Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways von Yin, Lei, Wu, Nan, Curtin, Joshua C, Qatanani, Mohammed, Szwergold, Nava R, Reid, Robert A, Waitt, Gregory M, Parks, Derek J, Pearce, Kenneth H, Wisely, G. Bruce, Lazar, Mitchell A

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Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064 von Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Parks, Derek J., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce

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Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene von Akwabi-Ameyaw, Adwoa, Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., Miller, Aaron B., Navas, Frank, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce

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6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity von Pellicciari, Roberto, Fiorucci, Stefano, Camaioni, Emidio, Clerici, Carlo, Costantino, Gabriele, Maloney, Patrick R, Morelli, Antonio, Parks, Derek J, Willson, Timothy M

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GSK4112, a Small Molecule Chemical Probe for the Cell Biology of the Nuclear Heme Receptor Rev-erbα von Grant, Daniel, Yin, Lei, Collins, Jon L, Parks, Derek J, Orband-Miller, Lisa A, Wisely, G. Bruce, Joshi, Shree, Lazar, Mitchell A, Willson, Timothy M, Zuercher, William J

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Structure of Rev-erbα bound to N-CoR reveals a unique mechanism of nuclear receptor–co-repressor interaction von Phelan, Caroline A, Gampe, Robert T, Lambert, Millard H, Parks, Derek J, Montana, Valerie, Bynum, Jane, Broderick, Timothy M, Hu, Xiao, Williams, Shawn P, Nolte, Robert T, Lazar, Mitchell A

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Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPAR α von Xu, H. Eric, Stanley, Thomas B, Montana, Valerie G, Lambert, Millard H, Shearer, Barry G, Cobb, Jeffery E, McKee, David D, Galardi, Cristin M, Plunket, Kelli D, Nolte, Robert T, Parks, Derek J, Moore, John T, Kliewer, Steven A, Willson, Timothy M, Stimmel, Julie B

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