A G-protein-biased S1P1 agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome von Evaristi, Maria Francesca, Poirier, Bruno, Chénedé, Xavier, Lefebvre, Anne-Marie, Roccon, Alain, Gillot, Florence, Beeské, Sandra, Corbier, Alain, Pruniaux-Harnist, Marie-Pierre, Janiak, Philip, Parkar, Ashfaq A

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First‐in‐human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G‐protein‐biased sphingosine‐1 p... von Bergougnan, Luc, Armani, Sara, Golor, Georg, Tardat, Agnes, Vitse, Olivier, Hurbin, Fabrice, Scemama, Michel, Poitiers, Franck, Radzik, David, Gaudin, Christophe, Hovsepian, Lionel, Muslin, Anthony J., Kirkesseli, Stephane, Deutsch, Paul, Parkar, Ashfaq A.

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Endothelial‐protective effects of a G‐protein‐biased sphingosine‐1 phosphate receptor‐1 agonist, SAR247799, in type‐2 diabetes rats and a randomized placebo‐controlled patient tria... von Bergougnan, Luc, Andersen, Grit, Plum‐Mörschel, Leona, Evaristi, Maria Francesca, Poirier, Bruno, Tardat, Agnes, Ermer, Marcel, Herbrand, Theresa, Arrubla, Jorge, Coester, Hans Veit, Sansone, Roberto, Heiss, Christian, Vitse, Olivier, Hurbin, Fabrice, Boiron, Rania, Benain, Xavier, Radzik, David, Janiak, Philip, Muslin, Anthony J., Hovsepian, Lionel, Kirkesseli, Stephane, Deutsch, Paul, Parkar, Ashfaq A.

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A label‐free impedance assay in endothelial cells differentiates the activation and desensitization properties of clinical S1P1 agonists von Grailhe, Patrick, Boutarfa‐Madec, Asma, Beauverger, Philippe, Janiak, Philip, Parkar, Ashfaq A.

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A G protein-biased S1P 1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers von Poirier, Bruno, Briand, Veronique, Kadereit, Dieter, Schäfer, Matthias, Wohlfart, Paulus, Philippo, Marie-Claire, Caillaud, Dominique, Gouraud, Laurent, Grailhe, Patrick, Bidouard, Jean-Pierre, Trellu, Marc, Muslin, Anthony J, Janiak, Philip, Parkar, Ashfaq A

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A label-free impedance assay in endothelial cells differentiates the activation and desensitization properties of clinical S1P 1 agonists von Grailhe, Patrick, Boutarfa-Madec, Asma, Beauverger, Philippe, Janiak, Philip, Parkar, Ashfaq A

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Solution Structure of the Link Module: A Hyaluronan-Binding Domain Involved in Extracellular Matrix Stability and Cell Migration von Kohda, Daisuke, Morton, Craig J, Parkar, Ashfaq A, Hatanaka, Hideki, Inagaki, Fuyuhiko M, Campbell, Iain D, Day, Anthony J

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A G-protein-biased S1P.sub.1 agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome von Evaristi, Maria Francesca, Poirier, Bruno, Chénedé, Xavier, Lefebvre, Anne-Marie, Roccon, Alain, Gillot, Florence, Beeské, Sandra, Corbier, Alain, Pruniaux-Harnist, Marie-Pierre, Janiak, Philip, Parkar, Ashfaq A

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Molecular MRI of collagen to diagnose and stage liver fibrosis von Fuchs, Bryan C, Wang, Huifang, Yang, Yan, Wei, Lan, Polasek, Miloslav, Schühle, Daniel T, Lauwers, Gregory Y, Parkar, Ashfaq, Sinskey, Anthony J, Tanabe, Kenneth K, Caravan, Peter

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Overlapping sites on the Link module of human TSG-6 mediate binding to hyaluronan and chondroitin-4-sulphate von Parkar, Ashfaq A, Day, Anthony J

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TSG-6 interacts with hyaluronan and aggrecan in a pH-dependent manner via a common functional element: implications for its regulation in inflamed cartilage von Parkar, Ashfaq A, Kahmann, Jan D, Howat, Sarah L.T, Bayliss, Michael T, Day, Anthony J

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A G protein–biased S1P1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers

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X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase von McLean, Larry R., Zhang, Ying, Zaidi, Nisha, Bi, Xiping, Wang, Rachel, Dharanipragada, Ram, Jurcak, John G., Gillespy, Timothy A., Zhao, Zhicheng, Musick, Kwon Y., Choi, Yong-Mi, Barrague, Matthieu, Peppard, Jane, Smicker, Matthew, Duguid, Mei, Parkar, Ashfaq, Fordham, Jeremy, Kominos, Dorothea

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Molecular MRI of Collagen to Diagnose and Stage Liver Fibrosis von Fuchs, Bryan C, Wang, Huifang, Yang, Yanfei, Wei, Lan, Polasek, Miloslav, Schühle, Daniel T, Lauwers, Gregory Y, Parkar, Ashfaq, Sinskey, Anthony J, Tanabe, Kenneth Kenji, Caravan, Peter D

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A G-protein-biased S1P1 agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome von Maria Francesca Evaristi, Bruno Poirier, Xavier Chénedé, Anne-Marie Lefebvre, Alain Roccon, Florence Gillot, Sandra Beeské, Alain Corbier, Marie-Pierre Pruniaux-Harnist, Philip Janiak, Ashfaq A Parkar

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Understanding DP receptor antagonism using a CoMSIA approach von Mu, Lan, Aguiar, Joacy, Ardati, Ali, Cao, Bin, Gardner, Charles J., Gillespy, Tim, Harris, Keith, Lim, Sungtaek, Marcus, Robert, Morize, Isabelle, Parkar, Ashfaq, Stefany, David, Li, Yi, Vaz, Roy J., Cirovic, Dragan A.

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LPA1 ANTAGONISTS FOR TREATING INTERSTITIAL LUNG DISEASE von TIRUCHERAI, Giridhar S, FISCHER, Aryeh, TATOSIAN, Daniel A, TAO, Shiwei, PARKAR, Ashfaq A, GREENBERG, Steven

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LPA1 ANTAGONISTS FOR TREATING INTERSTITIAL LUNG DISEASE von TIRUCHERAI, Giridhar S, FISCHER, Aryeh, TATOSIAN, Daniel A, TAO, Shiwei, PARKAR, Ashfaq A, GREENBERG, Steven

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4-[5-(3-CHLORO-PHENOXY)-OXAZOLO[5,4-D]PYRIMIDIN-2-YL]-2,6-DIMETHYL-PHENOXY}-ACETIC ACID FOR USE IN THE PREVENTION OR TREATMENT OF ACUTE KIDNEY INJURY von KADEREIT, Dieter, GRATZER, Sabine, POIRIER, Bruno, SCHAEFER, Matthias, WOHLFART, Paulus, JANIAK, Philip, HUEBSCHLE, Thomas, PARKAR, Ashfaq, BRIAND, Véronique

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LPA1 ANTAGONISTS FOR TREATING INTERSTITIAL LUNG DISEASE von FISCHER, Aryeh, TATOSIAN, Daniel A, TSUJIMOTO, Akihide, ELPERS, Brandon, TAO, Shiwei, PARKAR, Ashfaq A, KIM, Sinae, GREENBERG, Steven, TIRUCHERAI, Giridhar

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