Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes von Hett, Erik C, Xu, Hua, Geoghegan, Kieran F, Gopalsamy, Ariamala, Kyne, Robert E, Menard, Carol A, Narayanan, Arjun, Parikh, Mihir D, Liu, Shenping, Roberts, Lee, Robinson, Ralph P, Tones, Michael A, Jones, Lyn H

Volltext

Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors von Han, Seungil, Czerwinski, Robert M, Caspers, Nicole L, Limburg, David C, Ding, WeiDong, Wang, Hong, Ohren, Jeffrey F, Rajamohan, Francis, McLellan, Thomas J, Unwalla, Ray, Choi, Chulho, Parikh, Mihir D, Seth, Nilufer, Edmonds, Jason, Phillips, Chris, Shakya, Subarna, Li, Xin, Spaulding, Vikki, Hughes, Samantha, Cook, Andrew, Robinson, Colin, Mathias, John P, Navratilova, Iva, Medley, Quintus G, Anderson, David R, Kurumbail, Ravi G, Aulabaugh, Ann

Volltext

Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Au... von Vazquez, Michael L, Kaila, Neelu, Strohbach, Joseph W, Trzupek, John D, Brown, Matthew F, Flanagan, Mark E, Mitton-Fry, Mark J, Johnson, Timothy A, TenBrink, Ruth E, Arnold, Eric P, Basak, Arindrajit, Heasley, Steven E, Kwon, Soojin, Langille, Jonathan, Parikh, Mihir D, Griffin, Sarah H, Casavant, Jeffrey M, Duclos, Brian A, Fenwick, Ashley E, Harris, Thomas M, Han, Seungil, Caspers, Nicole, Dowty, Martin E, Yang, Xin, Banker, Mary Ellen, Hegen, Martin, Symanowicz, Peter T, Li, Li, Wang, Lu, Lin, Tsung H, Jussif, Jason, Clark, James D, Telliez, Jean-Baptiste, Robinson, Ralph P, Unwalla, Ray

Volltext

A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS von Xu, Hua, Hett, Erik C, Gopalsamy, Ariamala, Parikh, Mihir D, Geoghegan, Kieran F, Kyne, Jr, Robert E, Menard, Carol A, Narayanan, Arjun, Robinson, Ralph P, Johnson, Douglas S, Tones, Michael A, Jones, Lyn H

Volltext

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis von Fadeyi, Olugbeminiyi, Parikh, Mihir D., Chen, Ming Z., Kyne Jr, Robert E., Taylor, Alexandria P., O'Doherty, Inish, Kaiser, Stephen E., Barbas, Sabrina, Niessen, Sherry, Shi, Manli, Weinrich, Scott L., Kath, John C., Jones, Lyn H., Robinson, Ralph P.

Volltext

Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3–9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase von Taylor, Alexandria P, Swewczyk, Magdalena, Kennedy, Steven, Trush, Viacheslav V, Wu, Hong, Zeng, Hong, Dong, Aiping, Ferreira de Freitas, Renato, Tatlock, John, Kumpf, Robert A, Wythes, Martin, Casimiro-Garcia, Agustin, Denny, Rajiah Aldrin, Parikh, Mihir D, Li, Fengling, Barsyte-Lovejoy, Dalia, Schapira, Matthieu, Vedadi, Masoud, Brown, Peter J, Arrowsmith, Cheryl H, Owen, Dafydd R

Volltext

Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular A... von Gopalsamy, Ariamala, Narayanan, Arjun, Liu, Shenping, Parikh, Mihir D, Kyne, Robert E, Fadeyi, Olugbeminiyi, Tones, Michael A, Cherry, Jonathan J, Nabhan, Joseph F, LaRosa, Gregory, Petersen, Donna N, Menard, Carol, Foley, Timothy L, Noell, Stephen, Ren, Yong, Loria, Paula M, Maglich-Goodwin, Jodi, Rong, Haojing, Jones, Lyn H

Volltext

Aminopyrazole Carboxamide Bruton’s Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning von Schnute, Mark E, Benoit, Stephen E, Buchler, Ingrid P, Caspers, Nicole, Grapperhaus, Margaret L, Han, Seungil, Hotchandani, Rajeev, Huang, Nelson, Hughes, Robert O, Juba, Brian M, Kim, Kyung-Hee, Liu, Erica, McCarthy, Erin, Messing, Dean, Miyashiro, Joy S, Mohan, Shashi, O’Connell, Thomas N, Ohren, Jeffrey F, Parikh, Mihir D, Schmidt, Michelle, Selness, Shaun R, Springer, John R, Thanabal, Venkataraman, Trujillo, John I, Walker, Daniel P, Wan, Zhao-Kui, Withka, Jane M, Wittwer, Arthur J, Wood, Nancy L, Xing, Li, Zapf, Christoph W, Douhan, John

Volltext

Benzothiophene inhibitors of MK2. Part 2: Improvements in kinase selectivity and cell potency von Anderson, David R., Meyers, Marvin J., Kurumbail, Ravi G., Caspers, Nicole, Poda, Gennadiy I., Long, Scott A., Pierce, Betsy S., Mahoney, Matthew W., Mourey, Robert J., Parikh, Mihir D.

Volltext

Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode von Meyers, Marvin J., Pelc, Matthew, Kamtekar, Satwik, Day, Jacqueline, Poda, Gennadiy I., Hall, Molly K., Michener, Marshall L., Reitz, Beverly A., Mathis, Karl J., Pierce, Betsy S., Parikh, Mihir D., Mischke, Deborah A., Long, Scott A., Parlow, John J., Anderson, David R., Thorarensen, Atli

Volltext

Biochemical, cellular, and anti-inflammatory properties of a potent, selective, orally bioavailable benzamide inhibitor of Rho kinase activity von Rajagopalan, Lakshman E, Davies, Michael S, Kahn, Larry E, Kornmeier, Christine M, Shimada, Hideaki, Steiner, Toni A, Zweifel, Ben S, Wendling, Jay M, Payne, Maria A, Loeffler, Richard F, Case, Brenda L, Norton, Monica B, Parikh, Mihir D, Nemirovskiy, Olga V, Mourey, Robert J, Masferrer, Jaime L, Misko, Thomas P, Kolodziej, Stephen A

Volltext

Demonstration of a Multikilogram-Scale Birch Reduction and Evaluation of Alternative Synthetic Routes to a Ketalized Cyclohexene Derivative von Goetz, Adam E., Arcari, Joel, Bagley, Scott W., Hicklin, Robert, Jin, Liangxue, Jin, Zuxi, Li, Xinnan, Liu, Zhiqing, McWilliams, J. Christopher, Parikh, Mihir D., Potter, Tyler, Smith, William J., Sun, Lijie, Trujillo, John, Wang, Pan, Zhao, Xin

Volltext

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease von Gopalsamy, Ariamala, Aulabaugh, Ann E., Barakat, Amey, Beaumont, Kevin C., Cabral, Shawn, Canterbury, Daniel P., Casimiro-Garcia, Agustin, Chang, Jeanne S., Chen, Ming Z., Choi, Chulho, Dow, Robert L., Fadeyi, Olugbeminiyi O., Feng, Xidong, France, Scott P., Howard, Roger M., Janz, Jay M., Jasti, Jayasankar, Jasuja, Reema, Jones, Lyn H., King-Ahmad, Amanda, Knee, Kelly M., Kohrt, Jeffrey T., Limberakis, Chris, Liras, Spiros, Martinez, Carlos A., McClure, Kim F., Narayanan, Arjun, Narula, Jatin, Novak, Jonathan J., O'Connell, Thomas N., Parikh, Mihir D., Piotrowski, David W., Plotnikova, Olga, Robinson, Ralph P., Sahasrabudhe, Parag, Sharma, Raman, Thuma, Benjamin A., Vasa, Dipy, Wei, Liuqing, Wenzel, A. Zane, Withka, Jane M., Xiao, Jun, Yayla, Hatice G.

Volltext

Discovery of + (2 -{4 -[2 -(5,6,7,8 -tetrahydro -1,8 -naphthyridin -2-yl )ethoxy ]phenyl} -cyclopropyl )acetic acid as potent and selective αvβ3 inhibitor : Design, synthesis, and... von NAGARAJAN, Srinivasan R, LU, Hwang-Fun, KEENE, Jeffery L, DUFFIN, Tiffany, ENGLEMAN, V. Wayne, FINN, Mary B, FREEMAN, Sandra K, KLOVER, Jon A, NICKOLS, G. Alan, NICKOLS, Maureen A, SHANNON, Kristen E, STEININGER, Christina A, GASIECKI, Alan F, WESTLIN, William F, WESTLIN, Marisa M, WILLIAMS, Melanie L, KHANNA, Ish K, PARIKH, Mihir D, DESAI, Bipinchandra N, ROGERS, Thomas E, CLARE, Michael, CHEN, Barbara B, RUSSELL, Mark A

Volltext

Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma von Sweerus, Kelly, MD, Lachowicz-Scroggins, Marrah, PhD, Gordon, Erin, MD, LaFemina, Michael, MD, Huang, Xiaozhu, MD, Parikh, Mihir, MD, Kanegai, Cindy, MD, Fahy, John V., MD, Frank, James A., MD

Volltext

A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpSElectronic supplementary information (ESI) available: Additional experimental... von Xu, Hua, Hett, Erik C, Gopalsamy, Ariamala, Parikh, Mihir D, Geoghegan, Kieran F, Kyne, Robert E, Menard, Carol A, Narayanan, Arjun, Robinson, Ralph P, Johnson, Douglas S, Tones, Michael A, Jones, Lyn H

Volltext

Porphyrins with exocyclic rings. Part 19: Efficient syntheses of phenanthrolinoporphyrins von Lash, Timothy D., Lin, Yanning, Novak, Bennett H., Parikh, Mihir D.

Volltext

Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective alphavbeta3 inhibitor: design, synthesis, and optimi... von Nagarajan, Srinivasan R, Lu, Hwang-Fun, Gasiecki, Alan F, Khanna, Ish K, Parikh, Mihir D, Desai, Bipinchandra N, Rogers, Thomas E, Clare, Michael, Chen, Barbara B, Russell, Mark A, Keene, Jeffery L, Duffin, Tiffany, Engleman, V Wayne, Finn, Mary B, Freeman, Sandra K, Klover, Jon A, Nickols, G Alan, Nickols, Maureen A, Shannon, Kristen E, Steininger, Christina A, Westlin, William F, Westlin, Marisa M, Williams, Melanie L

Volltext

Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective α vβ 3 inhibitor: Design, synthesis, and optimizatio... von Nagarajan, Srinivasan R., Lu, Hwang-Fun, Gasiecki, Alan F., Khanna, Ish K., Parikh, Mihir D., Desai, Bipinchandra N., Rogers, Thomas E., Clare, Michael, Chen, Barbara B., Russell, Mark A., Keene, Jeffery L., Duffin, Tiffany, Engleman, V. Wayne, Finn, Mary B., Freeman, Sandra K., Klover, Jon A., Nickols, G. Alan, Nickols, Maureen A., Shannon, Kristen E., Steininger, Christina A., Westlin, William F., Westlin, Marisa M., Williams, Melanie L.

Volltext

Dérivés de pyrrolo[2,3-d]pyrimidine en tant qu'inhibiteurs de janus kinases (jak) von FLANAGAN, Mark Edward, TRZUPEK, John David, STROHBACH, Joseph Walter, TENBRINK, Ruth E, JOHNSON, Timothy Allan, KAILA, Neelu, GONZALES, Andrea, UNWALLA, Rayomand Jal, VAZQUEZ, Michael L, MITTON-FRY, Mark J, BROWN, Matthew Frank, FENWICK, Ashley Edward, MIHIR, D. Parikh

Volltext bestellen