mRNA Vaccines in the COVID-19 Pandemic and Beyond von Hogan, Michael J, Pardi, Norbert

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Development of vaccines and antivirals for combating viral pandemics von Pardi, Norbert, Weissman, Drew

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mRNA Innovates the Vaccine Field von Pardi, Norbert

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In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels von Rothgangl, Tanja, Dennis, Melissa K., Lin, Paulo J. C., Oka, Rurika, Witzigmann, Dominik, Villiger, Lukas, Qi, Weihong, Hruzova, Martina, Kissling, Lucas, Lenggenhager, Daniela, Borrelli, Costanza, Egli, Sabina, Frey, Nina, Bakker, Noëlle, Walker, John A., Kadina, Anastasia P., Victorov, Denis V., Pacesa, Martin, Kreutzer, Susanne, Kontarakis, Zacharias, Moor, Andreas, Jinek, Martin, Weissman, Drew, Stoffel, Markus, van Boxtel, Ruben, Holden, Kevin, Pardi, Norbert, Thöny, Beat, Häberle, Johannes, Tam, Ying K., Semple, Sean C., Schwank, Gerald

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Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA von Rizvi, Fatima, Everton, Elissa, Smith, Anna R., Liu, Hua, Osota, Elizabeth, Beattie, Mitchell, Tam, Ying, Pardi, Norbert, Weissman, Drew, Gouon-Evans, Valerie

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Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes von Pardi, Norbert, Tuyishime, Steven, Muramatsu, Hiromi, Kariko, Katalin, Mui, Barbara L., Tam, Ying K., Madden, Thomas D., Hope, Michael J., Weissman, Drew

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Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine von Muramatsu, Hiromi, Lam, Kieu, Bajusz, Csaba, Laczkó, Dorottya, Karikó, Katalin, Schreiner, Petra, Martin, Alan, Lutwyche, Peter, Heyes, James, Pardi, Norbert

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D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization von Weissman, Drew, Alameh, Mohamad-Gabriel, de Silva, Thushan, Collini, Paul, Hornsby, Hailey, Brown, Rebecca, LaBranche, Celia C., Edwards, Robert J., Sutherland, Laura, Santra, Sampa, Mansouri, Katayoun, Gobeil, Sophie, McDanal, Charlene, Pardi, Norbert, Hengartner, Nick, Lin, Paulo J.C., Tam, Ying, Shaw, Pamela A., Lewis, Mark G., Boesler, Carsten, Şahin, Uğur, Acharya, Priyamvada, Haynes, Barton F., Korber, Bette, Montefiori, David C.

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Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination von Pardi, Norbert, Hogan, Michael J., Pelc, Rebecca S., Muramatsu, Hiromi, Andersen, Hanne, DeMaso, Christina R., Dowd, Kimberly A., Sutherland, Laura L., Scearce, Richard M., Parks, Robert, Wagner, Wendeline, Granados, Alex, Greenhouse, Jack, Walker, Michelle, Willis, Elinor, Yu, Jae-Sung, McGee, Charles E., Sempowski, Gregory D., Mui, Barbara L., Tam, Ying K., Huang, Yan-Jang, Vanlandingham, Dana, Holmes, Veronica M., Balachandran, Harikrishnan, Sahu, Sujata, Lifton, Michelle, Higgs, Stephen, Hensley, Scott E., Madden, Thomas D., Hope, Michael J., Karikó, Katalin, Santra, Sampa, Graham, Barney S., Lewis, Mark G., Pierson, Theodore C., Haynes, Barton F., Weissman, Drew

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Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice von Martinez, David R, Schäfer, Alexandra, Leist, Sarah R, De la Cruz, Gabriela, West, Ande, Atochina-Vasserman, Elena N, Lindesmith, Lisa C, Pardi, Norbert, Parks, Robert, Barr, Maggie, Li, Dapeng, Yount, Boyd, Saunders, Kevin O, Weissman, Drew, Haynes, Barton F, Montgomery, Stephanie A, Baric, Ralph S

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Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies von Pardi, Norbert, Parkhouse, Kaela, Kirkpatrick, Ericka, McMahon, Meagan, Zost, Seth J., Mui, Barbara L., Tam, Ying K., Karikó, Katalin, Barbosa, Christopher J., Madden, Thomas D., Hope, Michael J., Krammer, Florian, Hensley, Scott E., Weissman, Drew

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Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge von Pardi, Norbert, Secreto, Anthony J., Shan, Xiaochuan, Debonera, Fotini, Glover, Joshua, Yi, Yanjie, Muramatsu, Hiromi, Ni, Houping, Mui, Barbara L., Tam, Ying K., Shaheen, Farida, Collman, Ronald G., Karikó, Katalin, Danet-Desnoyers, Gwenn A., Madden, Thomas D., Hope, Michael J., Weissman, Drew

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Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses von Pardi, Norbert, Hogan, Michael J, Naradikian, Martin S, Parkhouse, Kaela, Cain, Derek W, Jones, Letitia, Moody, M Anthony, Verkerke, Hans P, Myles, Arpita, Willis, Elinor, LaBranche, Celia C, Montefiori, David C, Lobby, Jenna L, Saunders, Kevin O, Liao, Hua-Xin, Korber, Bette T, Sutherland, Laura L, Scearce, Richard M, Hraber, Peter T, Tombácz, István, Muramatsu, Hiromi, Ni, Houping, Balikov, Daniel A, Li, Charles, Mui, Barbara L, Tam, Ying K, Krammer, Florian, Karikó, Katalin, Polacino, Patricia, Eisenlohr, Laurence C, Madden, Thomas D, Hope, Michael J, Lewis, Mark G, Lee, Kelly K, Hu, Shiu-Lok, Hensley, Scott E, Cancro, Michael P, Haynes, Barton F, Weissman, Drew

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Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema von Szőke, Dániel, Kovács, Gábor, Kemecsei, Éva, Bálint, László, Szoták-Ajtay, Kitti, Aradi, Petra, Styevkóné Dinnyés, Andrea, Mui, Barbara L., Tam, Ying K., Madden, Thomas D., Karikó, Katalin, Kataru, Raghu P., Hope, Michael J., Weissman, Drew, Mehrara, Babak J., Pardi, Norbert, Jakus, Zoltán

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PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated... von Parhiz, Hamideh, Shuvaev, Vladimir V., Pardi, Norbert, Khoshnejad, Makan, Kiseleva, Raisa Yu, Brenner, Jacob S., Uhler, Thomas, Tuyishime, Steven, Mui, Barbara L., Tam, Ying K., Madden, Thomas D., Hope, Michael J., Weissman, Drew, Muzykantov, Vladimir R.

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Development of a pentavalent broadly protective nucleoside-modified mRNA vaccine against influenza B viruses von Pardi, Norbert, Carreño, Juan Manuel, O’Dell, George, Tan, Jessica, Bajusz, Csaba, Muramatsu, Hiromi, Rijnink, Willemijn, Strohmeier, Shirin, Loganathan, Madhumathi, Bielak, Dominika, Sung, Molly M. H., Tam, Ying K., Krammer, Florian, McMahon, Meagan

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New Kids on the Block: RNA-Based Influenza Virus Vaccines von Scorza, Francesco Berlanda, Pardi, Norbert

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Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier von Marcos-Contreras, Oscar A., Greineder, Colin F., Kiseleva, Raisa Yu, Parhiz, Hamideh, Walsh, Landis R., Zuluaga-Ramirez, Viviana, Myerson, Jacob W., Hood, Elizabeth D., Villa, Carlos H., Tombacz, Istvan, Pardi, Norbert, Seliga, Alecia, Mui, Barbara L., Tam, Ying K., Glassman, Patrick M., Shuvaev, Vladimir V., Nong, Jia, Brenner, Jacob S., Khoshnejad, Makan, Madden, Tom, Weissmann, Drew, Persidsky, Yuri, Muzykantov, Vladimir R.

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Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE) von Parhiz, Hamideh, Brenner, Jacob S., Patel, Priyal N., Papp, Tyler E., Shahnawaz, Hamna, Li, Qin, Shi, Ruiqi, Zamora, Marco E., Yadegari, Amir, Marcos-Contreras, Oscar A., Natesan, Ambika, Pardi, Norbert, Shuvaev, Vladimir V., Kiseleva, Raisa, Myerson, Jacob W., Uhler, Thomas, Riley, Rachel S., Han, Xuexiang, Mitchell, Michael J., Lam, Kieu, Heyes, James, Weissman, Drew, Muzykantov, Vladimir R.

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Nucleoside-Modified mRNA Vaccines Protect IFNAR -/- Mice against Crimean-Congo Hemorrhagic Fever Virus Infection von Appelberg, Sofia, John, Lijo, Pardi, Norbert, Végvári, Ákos, Bereczky, Sándor, Ahlén, Gustaf, Monteil, Vanessa, Abdurahman, Samir, Mikaeloff, Flora, Beattie, Mitchell, Tam, Ying, Sällberg, Matti, Neogi, Ujjwal, Weissman, Drew, Mirazimi, Ali

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