RIT1 oncoproteins escape LZTR1-mediated proteolysis von Castel, Pau, Cheng, Alice, Cuevas-Navarro, Antonio, Everman, David B., Papageorge, Alex G., Simanshu, Dhirendra K., Tankka, Alexandra, Galeas, Jacqueline, Urisman, Anatoly, McCormick, Frank

Volltext

Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer von Zhang, Haisheng, Schaefer, Antje, Wang, Yichen, Hodge, Richard G, Blake, Devon R, Diehl, J Nathaniel, Papageorge, Alex G, Stachler, Matthew D, Liao, Jennifer, Zhou, Jin, Wu, Zhong, Akarca, Fahire G, de Klerk, Leonie K, Derks, Sarah, Pierobon, Mariaelena, Hoadley, Katherine A, Wang, Timothy C, Church, George, Wong, Kwok-Kin, Petricoin, Emanuel F, Cox, Adrienne D, Lowy, Douglas R, Der, Channing J, Bass, Adam J

Volltext

Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK) von Li, Guorong, Du, Xiaoli, Vass, William C, Papageorge, Alex G, Lowy, Douglas R, Qian, Xiaolan

Volltext

Receptor tyrosine kinase activation of RhoA is mediated by AKT phosphorylation of DLC1 von Tripathi, Brajendra K, Grant, Tiera, Qian, Xiaolan, Zhou, Ming, Mertins, Philipp, Wang, Dunrui, Papageorge, Alex G, Tarasov, Sergey G, Hunter, Kent W, Carr, Steven A, Lowy, Douglas R

Volltext

Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein von Tripathi, Brajendra K., Anderman, Meghan F., Bhargava, Disha, Boccuzzi, Luciarita, Qian, Xiaolan, Wang, Dunrui, Durkin, Marian E., Papageorge, Alex G., de Miguel, Fernando J., Politi, Katerina, Walters, Kylie J., Doroshow, James H., Lowy, Douglas R.

Volltext

CDK5 is a major regulator of the tumor suppressor DLC1 von Tripathi, Brajendra K, Qian, Xiaolan, Mertins, Philipp, Wang, Dunrui, Papageorge, Alex G, Carr, Steven A, Lowy, Douglas R

Volltext

Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities von Qian, Xiaolan, Li, Guorong, Asmussen, Holly K, Asnaghi, Laura, Vass, William C, Braverman, Richard, Yamada, Kenneth M, Popescu, Nicholas C, Papageorge, Alex G, Lowy, Douglas R

Volltext

Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis von Crawford, Nigel P S, Qian, Xiaolan, Ziogas, Argyrios, Papageorge, Alex G, Boersma, Brenda J, Walker, Renard C, Lukes, Luanne, Rowe, William L, Zhang, Jinghui, Ambs, Stefan, Lowy, Douglas R, Anton-Culver, Hoda, Hunter, Kent W

Volltext

SRC and ERK cooperatively phosphorylate DLC1 and attenuate its Rho-GAP and tumor suppressor functions von Tripathi, Brajendra K, Anderman, Meghan F, Qian, Xiaolan, Zhou, Ming, Wang, Dunrui, Papageorge, Alex G, Lowy, Douglas R

Volltext

The pro-oncogenic noncanonical activity of a RAS•GTP:RanGAP1 complex facilitates nuclear protein export von Tripathi, Brajendra K., Hirsh, Nicole H., Qian, Xiaolan, Durkin, Marian E., Wang, Dunrui, Papageorge, Alex G., Lake, Ross, Evrard, Yvonne A., Marcus, Adam I., Ramalingam, Suresh S., Dasso, Mary, Vousden, Karen H., Doroshow, James H., Walters, Kylie J., Lowy, Douglas R.

Volltext

Abstract 4377: AKT positively regulates Rho-GTP by attenuating the GAP activity of the DLC1 tumor suppressor: a mechanistic study with translational implications von Tripathi, Brajendra K., Grant, Tiera, Mertins, Philipp, Qian, Xiaolan, Wang, Dunrui, Papageorge, Alex G., Carr, Steven A., Lowy, Douglas R.

Volltext

The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties von Qian, Xiaolan, Esteban, Luis, Vass, William C., Upadhyaya, Cheerag, Papageorge, Alex G., Yienger, Kate, Ward, Jerrold M., Lowy, Douglas R., Santos, Eugenio

Volltext

Abstract 4235: Phosphorylation of Serine 861 in the ECT2 guanine nucleotide exchange factor activates Rho family GTPases and is a biomarker for several tumor types von Wang, Dunrui, Qian, Xiaolan, Eng, Sarah, Nellore, Shivani, Papageorge, Alex G., Lowy, Douglas R.

Volltext

Ras-Specific Exchange Factor GRF: Oligomerization through Its Dbl Homology Domain and Calcium-Dependent Activation of Raf von Anborgh, Pieter H., Qian, Xiaolan, Papageorge, Alex G., Vass, William C., DeClue, Jeffrey E., Lowy, Douglas R.

Volltext

Abstract 3957: SRC inhibitors dephosphorylate and reactivate the DLC1 tumor suppressor: A new biomarker of clinical response von Tripathi, Brajendra K., Anderman, Meghan, Qian, Xiaolan, Zhou, Ming, Wang, Dunrui, Papageorge, Alex G., Lowy, Douglas R.

Volltext

Abstract 1364: Direct phosphorylation and attenuation of the DLC1 tumor suppressor by SRC kinase: a new mechanism of SRC-dependent activation of Rho with translational implications von Tripathi, Brajendra K., Qian, Xiaolan, Zhou, Ming, Wang, Dunrui, Durkin, Marian, Papageorge, Alex G., Lowy, Douglas R.

Volltext

N Terminus of Sos1 Ras Exchange Factor: Critical Roles for the Dbl and Pleckstrin Homology Domains von Qian, Xiaolan, Vass, William C., Papageorge, Alex G., Anborgh, Pieter H., Lowy, Douglas R.

Volltext

Abstract 1727: Cytoplasmic EZH2 and the DLC1 tumor suppressor are regulated by the CRM1 nuclear export protein and by specific complex formation between mutant KRAS and RAN-GAP von Tripathi, Brajendra, Hirsh, Nicole, Hansen, David, Qian, Xiaolan, Wang, Dunrui, Durkin, Marian E., Lim, Ashley, Papageorge, Alex G., Ramalingham, Suresh S., Marcus, Adam I., Lowy, Douglas R.

Volltext

Abstract 2155: Inactivation of the tumor suppressor DLC1 by the oncogenes SRC and ERK1 in lung adenocarcinoma von Tripathi, Brajendra K., Qian, Xiaolan, Grant, Tiera, Mertins, Philipp, Wang, Dunrui, Papageorge, Alex G., Carr, Steven A., Lowy, Douglas R.

Volltext

Inhibition of cell growth by lovastatin is independent of ras function von DECLUE, J. E, VASS, W. C, PAPAGEORGE, A. G, LOWY, D. R, WILLUMSEN, B. M

Volltext