Viral vectors for therapy of neurologic diseases von Choudhury, Sourav R., Hudry, Eloise, Maguire, Casey A., Sena-Esteves, Miguel, Breakefield, Xandra O., Grandi, Paola

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Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition von Frost, Julianty, Galdeano, Carles, Soares, Pedro, Gadd, Morgan S., Grzes, Katarzyna M., Ellis, Lucy, Epemolu, Ola, Shimamura, Satoko, Bantscheff, Marcus, Grandi, Paola, Read, Kevin D., Cantrell, Doreen A., Rocha, Sonia, Ciulli, Alessio

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CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells von Han, Jianfeng, Chu, Jianhong, Keung Chan, Wing, Zhang, Jianying, Wang, Youwei, Cohen, Justus B., Victor, Aaron, Meisen, Walter H., Kim, Sung-hak, Grandi, Paola, Wang, Qi-En, He, Xiaoming, Nakano, Ichiro, Chiocca, E. Antonio, Glorioso III, Joseph C., Kaur, Balveen, Caligiuri, Michael A., Yu, Jianhua

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Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes von Bantscheff, Marcus, Drewes, Gerard, Hopf, Carsten, Savitski, Mikhail M, Dittmann, Antje, Grandi, Paola, Michon, Anne-Marie, Schlegl, Judith, Abraham, Yann, Becher, Isabelle, Bergamini, Giovanna, Boesche, Markus, Delling, Manja, Dümpelfeld, Birgit, Eberhard, Dirk, Huthmacher, Carola, Mathieson, Toby, Poeckel, Daniel, Reader, Valérie, Strunk, Katja, Sweetman, Gavain, Kruse, Ulrich, Neubauer, Gitte, Ramsden, Nigel G

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Discovery of I‑BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition von Theodoulou, Natalie H, Bamborough, Paul, Bannister, Andrew J, Becher, Isabelle, Bit, Rino A, Che, Ka Hing, Chung, Chun-wa, Dittmann, Antje, Drewes, Gerard, Drewry, David H, Gordon, Laurie, Grandi, Paola, Leveridge, Melanie, Lindon, Matthew, Michon, Anne-Marie, Molnar, Judit, Robson, Samuel C, Tomkinson, Nicholas C. O, Kouzarides, Tony, Prinjha, Rab K, Humphreys, Philip G

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Click chemistry enables preclinical evaluation of targeted epigenetic therapies von Tyler, Dean S., Vappiani, Johanna, Cañeque, Tatiana, Lam, Enid Y. N., Ward, Aoife, Gilan, Omer, Chan, Yih-Chih, Hienzsch, Antje, Rutkowska, Anna, Werner, Thilo, Wagner, Anne J., Lugo, Dave, Gregory, Richard, Molina, Cesar Ramirez, Garton, Neil, Wellaway, Christopher R., Jackson, Susan, MacPherson, Laura, Figueiredo, Margarida, Stolzenburg, Sabine, Bell, Charles C., House, Colin, Dawson, Sarah-Jane, Hawkins, Edwin D., Drewes, Gerard, Prinjha, Rab K., Rodriguez, Raphaël, Grandi, Paola, Dawson, Mark A.

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Network integration of thermal proteome profiling with multi-omics data decodes PARP inhibition von Burtscher, Mira L, Gade, Stephan, Garrido-Rodriguez, Martin, Rutkowska, Anna, Werner, Thilo, Eberl, H Christian, Petretich, Massimo, Knopf, Natascha, Zirngibl, Katharina, Grandi, Paola, Bergamini, Giovanna, Bantscheff, Marcus, Fälth-Savitski, Maria, Saez-Rodriguez, Julio

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Use of miRNA Response Sequences to Block Off-target Replication and Increase the Safety of an Unattenuated, Glioblastoma-targeted Oncolytic HSV von Mazzacurati, Lucia, Marzulli, Marco, Reinhart, Bonnie, Miyagawa, Yoshitaka, Uchida, Hiroaki, Goins, William F, Li, Aofei, Kaur, Balveen, Caligiuri, Michael, Cripe, Timothy, Chiocca, Nino, Amankulor, Nduka, Cohen, Justus B, Glorioso, Joseph C, Grandi, Paola

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Histone deacetylase 6 inhibition enhances oncolytic viral replication in glioma von Nakashima, Hiroshi, Kaufmann, Johanna K, Wang, Pin-Yi, Nguyen, Tran, Speranza, Maria-Carmela, Kasai, Kazue, Okemoto, Kazuo, Otsuki, Akihiro, Nakano, Ichiro, Fernandez, Soledad, Goins, William F, Grandi, Paola, Glorioso, Joseph C, Lawler, Sean, Cripe, Timothy P, Chiocca, E Antonio

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Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector von MCKEE, Trevor D, GRANDI, Paola, MOK, Wilson, ALEXANDRAKIS, George, INSIN, Numpon, ZIMMER, John P, BAWENDI, Moungi G, BOUCHER, Yves, BREAKEFIELD, Xandra O, JAIN, Rakesh K

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The Commonly Used PI3-Kinase Probe LY294002 Is an Inhibitor of BET Bromodomains von Dittmann, Antje, Werner, Thilo, Chung, Chun-Wa, Savitski, Mikhail M, Fälth Savitski, Maria, Grandi, Paola, Hopf, Carsten, Lindon, Matthew, Neubauer, Gitte, Prinjha, Rabinder K, Bantscheff, Marcus, Drewes, Gerard

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Effective Treatment of an Orthotopic Xenograft Model of Human Glioblastoma Using an EGFR-retargeted Oncolytic Herpes Simplex Virus von Uchida, Hiroaki, Marzulli, Marco, Nakano, Kenji, Goins, William F, Chan, Janet, Hong, Chang-Sook, Mazzacurati, Lucia, Yoo, Ji Young, Haseley, Amy, Nakashima, Hiroshi, Baek, Hyunjung, Kwon, Heechung, Kumagai, Izumi, Kuroki, Masahide, Kaur, Balveen, Chiocca, E Antonio, Grandi, Paola, Cohen, Justus B, Glorioso, Joseph C

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Updates on Oncolytic Virus Immunotherapy for Cancers von Peters, Cole, Grandi, Paola, Nigim, Fares

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Integrated metabolic-transcriptomic network identifies immunometabolic modulations in human macrophages von Chen, Hung-Jen, Sévin, Daniel C., Griffith, Guillermo R., Vappiani, Johanna, Booty, Lee M., van Roomen, Cindy P.A.A., Kuiper, Johan, Dunnen, Jeroen den, de Jonge, Wouter J., Prinjha, Rab K., Mander, Palwinder K., Grandi, Paola, Wyspianska, Beata S., de Winther, Menno P.J.

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GBM-Targeted oHSV Armed with Matrix Metalloproteinase 9 Enhances Anti-tumor Activity and Animal Survival von Sette, Paola, Amankulor, Nduka, Li, Aofei, Marzulli, Marco, Leronni, Daniela, Zhang, Mingdi, Goins, William F., Kaur, Balveen, Bolyard, Chelsea, Cripe, Timothy P., Yu, Jianhua, Chiocca, E. Antonio, Glorioso, Joseph C., Grandi, Paola

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Novel Mutations in gB and gH Circumvent the Requirement for Known gD Receptors in Herpes Simplex Virus 1 Entry and Cell-to-Cell Spread von Uchida, Hiroaki, Chan, Janet, Shrivastava, Indira, Reinhart, Bonnie, Grandi, Paola, Glorioso, Joseph C, Cohen, Justus B

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90S Pre-Ribosomes Include the 35S Pre-rRNA, the U3 snoRNP, and 40S Subunit Processing Factors but Predominantly Lack 60S Synthesis Factors von Grandi, Paola, Rybin, Vladimir, Baßler, Jochen, Petfalski, Elisabeth, Strauß, Daniela, Marzioch, Martina, Schäfer, Thorsten, Kuster, Bernhard, Tschochner, Herbert, Tollervey, David, Gavin, Anne-Claude, Hurt, Ed

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A Double Mutation in Glycoprotein gB Compensates for Ineffective gD-Dependent Initiation of Herpes Simplex Virus Type 1 Infection von UCHIDA, Hiroaki, CHAN, Janet, GOINS, William F, GRANDI, Paola, KUMAGAI, Izumi, COHEN, Justus B, GLORIOSO, Joseph C

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GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain von Bamborough, Paul, Barnett, Heather A, Becher, Isabelle, Bird, Mark J, Chung, Chun-wa, Craggs, Peter D, Demont, Emmanuel H, Diallo, Hawa, Fallon, David J, Gordon, Laurie J, Grandi, Paola, Hobbs, Clare I, Hooper-Greenhill, Edward, Jones, Emma J, Law, Robert P, Le Gall, Armelle, Lugo, David, Michon, Anne-Marie, Mitchell, Darren J, Prinjha, Rab K, Sheppard, Robert J, Watson, Allan J. B, Watson, Robert J

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Jet and Accretion-Disk Emission Untangled in 3C 273 von Grandi, Paola, Giorgio G. C. Palumbo

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