ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis von Towler, Paul, Staker, Bart, Prasad, Sridhar G., Menon, Saurabh, Tang, Jin, Parsons, Thomas, Ryan, Dominic, Fisher, Martin, Williams, David, Dales, Natalie A., Patane, Michael A., Pantoliano, Michael W.

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Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells von Grasberger, Bruce L, Lu, Tianbao, Schubert, Carsten, Parks, Daniel J, Carver, Theodore E, Koblish, Holly K, Cummings, Maxwell D, LaFrance, Louis V, Milkiewicz, Karen L, Calvo, Raul R, Maguire, Diane, Lattanze, Jennifer, Franks, Carol F, Zhao, Shuyuan, Ramachandren, Kannan, Bylebyl, Gwendolyn R, Zhang, Marie, Manthey, Carl L, Petrella, Eugene C, Pantoliano, Michael W, Deckman, Ingrid C, Spurlino, John C, Maroney, Anna C, Tomczuk, Bruce E, Molloy, Christopher J, Bone, Roger F

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Energetic Characterization of the Basic Fibroblast Growth Factor-Heparin Interaction: Identification of the Heparin Binding Domain von Thompson, Leo D, Pantoliano, Michael W, Springer, Barry A

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Multivalent Ligand-Receptor Binding Interactions in the Fibroblast Growth Factor System Produce a Cooperative Growth Factor and Heparin Mechanism for Receptor Dimerization von Pantoliano, Michael W, Horlick, Robert A, Springer, Barry A, Van Dyk, Drew E, Tobery, Timothy, Wetmore, Diana R, Lear, James D, Nahapetian, Ara T, Bradley, Jodi D, Sisk, William P

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Crystallographic and thermodynamic comparison of natural and synthetic ligands bound to streptavidin von Weber, P. C, Wendoloski, J. J, Pantoliano, M. W, Salemme, F. R

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In Vivo Tumor Targeting of a Recombinant Single-Chain Antigen-Binding Protein von Colcher, David, Bird, Robert, Roselli, Mario, Hardman, Karl D., Johnson, Syd, Pope, Sharon, Dodd, Steven W., Pantoliano, Michael W., Milenic, Diane E., Schlom, Jeffrey

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Large increases in general stability for subtilisin BPN' through incremental changes in the free energy of unfolding von Pantoliano, Michael W, Whitlow, Marc, Wood, Jay F, Dodd, Steven W, Hardman, Karl D, Rollence, Michele L, Bryan, Philip N

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Conformational stability, folding, and ligand-binding affinity of single-chain Fv immunoglobulin fragments expressed in Escherichia coli von Pantoliano, Michael W, Bird, Robert E, Johnson, Syd, Asel, Eric D, Dodd, Steven W, Wood, Jay F, Hardman, Karl D

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Crystal structure and ligand binding studies of a screened peptide complexed with streptavidin von Weber, Patricia C, Pantoliano, Michael W, Thompson, Leo D

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Site-Directed Mutagenesis and the Role of the Oxyanion Hole in Subtilisin von Bryan, Philip, Pantoliano, Michael W., Quill, Steven G., Hsiao, Humg-Yu, Poulos, Thomas

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The engineering of binding affinity at metal ion binding sites for the stabilization of proteins: subtilisin as a test case von Pantoliano, Michael W, Whitlow, Marc, Wood, Jay F, Rollence, Michele L, Finzel, Barry C, Gilliland, Gary L, Poulos, Thomas L, Bryan, Philip N

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Enzymes in organic synthesis: use of subtilisin and a highly stable mutant derived from multiple site-specific mutations von Wong, Chi Huey, Chen, S. T, Hennen, William J, Bibbs, Jeffrey A, Wang, Y. F, Liu, Jennifer L. C, Pantoliano, Michael W, Whitlow, Marc, Bryan, Philip N

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Protein engineering of subtilisin BPN': enhanced stabilization through the introduction of two cysteines to form a disulfide bond von Pantoliano, Michael W, Ladner, Robert C, Bryan, Philip N, Rollence, Michele L, Wood, Jay F, Poulos, Thomas L

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Identification and concerted function of two receptor binding surfaces on basic fibroblast growth factor required for mitogenesis von Springer, B A, Pantoliano, M W, Barbera, F A, Gunyuzlu, P L, Thompson, L D, Herblin, W F, Rosenfeld, S A, Book, G W

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Structure-Based Design of Synthetic Azobenzene Ligands for Streptavidin von Weber, P. C, Pantoliano, M. W, Simons, D. M, Salemme, F. R

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Immunological and structural characterization of a high affinity anti-fluorescein single-chain antibody von Bedzyk, W D, Weidner, K M, Denzin, L K, Johnson, L S, Hardman, K D, Pantoliano, M W, Asel, E D, Voss, E W

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Affinity chromatographic purification of angiotensin converting enzyme von Pantoliano, Michael W, Holmquist, Barton, Riordan, James F

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PH [hydrogen-ion concentration]-dependent migration of copper(II) to the vacant zinc-binding site of zinc-free bovine erythrocyte superoxide dismutase von Valentine, J.S, Pantoliano, M.W, McDonnell, P.J, Burger, A.R, Lippard, S.J

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Proteins designed for challenging environments and catalysis in organic solvents von Pantoliano, Michael W

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High-Density Miniaturized Thermal Shift Assays as a General Strategy for Drug Discovery von Pantoliano, Michael W., Petrella, Eugene C., Kwasnoski, Joseph D., Lobanov, Victor S., Myslik, James, Graf, Edward, Carver, Ted, Asel, Eric, Springer, Barry A., Lane, Pamela, Salemme, F.R.

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