Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer von Vennin, Claire, Murphy, Kendelle J., Morton, Jennifer P., Cox, Thomas R., Pajic, Marina, Timpson, Paul

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Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth von Rath, Nicola, Munro, June, Cutiongco, Marie Francene, Jagiełło, Alicja, Gadegaard, Nikolaj, McGarry, Lynn, Unbekandt, Mathieu, Michalopoulou, Evdokia, Kamphorst, Jurre J, Sumpton, David, Mackay, Gillian, Vennin, Claire, Pajic, Marina, Timpson, Paul, Olson, Michael F

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miR-139-5p Modulates Radiotherapy Resistance in Breast Cancer by Repressing Multiple Gene Networks of DNA Repair and ROS Defense von Pajic, Marina, Froio, Danielle, Daly, Sheridan, Doculara, Louise, Millar, Ewan, Graham, Peter H, Drury, Alison, Steinmann, Angela, de Bock, Charles E, Boulghourjian, Alice, Zaratzian, Anaiis, Carroll, Susan, Toohey, Joanne, O'Toole, Sandra A, Harris, Adrian L, Buffa, Francesca M, Gee, Harriet E, Hollway, Georgina E, Molloy, Timothy J

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Breaking the cycle: Targeting of NDRG1 to inhibit bi‐directional oncogenic cross‐talk between pancreatic cancer and stroma von Geleta, Bekesho, Park, Kyung Chan, Jansson, Patric J., Sahni, Sumit, Maleki, Sanaz, Xu, Zhihong, Murakami, Takashi, Pajic, Marina, Apte, Minoti V., Richardson, Des R., Kovacevic, Zaklina

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MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer von Cipponi, Arcadi, Goode, David L., Bedo, Justin, McCabe, Mark J., Pajic, Marina, Croucher, David R., Rajal, Alvaro Gonzalez, Junankar, Simon R., Saunders, Darren N., Lobachevsky, Pavel, Papenfuss, Anthony T., Nessem, Danielle, Nobis, Max, Warren, Sean C., Timpson, Paul, Cowley, Mark, Vargas, Ana C., Qiu, Min R., Generali, Daniele G., Keerthikumar, Shivakumar, Nguyen, Uyen, Corcoran, Niall M., Long, Georgina V., Blay, Jean-Yves, Thomas, David M.

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MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma von Castillo, Lesley, Young, Adelaide I. J., Mawson, Amanda, Schafranek, Pia, Steinmann, Angela M., Nessem, Danielle, Parkin, Ashleigh, Johns, Amber, Chou, Angela, Law, Andrew M. K., Lucas, Morghan C., Murphy, Kendelle J., Deng, Niantao, Gallego-Ortega, David, Caldon, Catherine E., Timpson, Paul, Pajic, Marina, Ormandy, Christopher J., Oakes, Samantha R.

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Precision Medicine for Advanced Pancreas Cancer: The Individualized Molecular Pancreatic Cancer Therapy (IMPaCT) Trial von Chantrill, Lorraine A, Nagrial, Adnan M, Watson, Clare, Johns, Amber L, Martyn-Smith, Mona, Simpson, Skye, Mead, Scott, Jones, Marc D, Samra, Jaswinder S, Gill, Anthony J, Watson, Nicole, Chin, Venessa T, Humphris, Jeremy L, Chou, Angela, Brown, Belinda, Morey, Adrienne, Pajic, Marina, Grimmond, Sean M, Chang, David K, Thomas, David, Sebastian, Lucille, Sjoquist, Katrin, Yip, Sonia, Pavlakis, Nick, Asghari, Ray, Harvey, Sandra, Grimison, Peter, Simes, John, Biankin, Andrew V

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Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer von Chou, Angela, Froio, Danielle, Nagrial, Adnan M, Parkin, Ashleigh, Murphy, Kendelle J, Chin, Venessa T, Wohl, Dalia, Steinmann, Angela, Stark, Rhys, Drury, Alison, Walters, Stacey N, Vennin, Claire, Burgess, Andrew, Pinese, Mark, Chantrill, Lorraine A, Cowley, Mark J, Molloy, Timothy J, Waddell, Nicola, Johns, Amber, Grimmond, Sean M, Chang, David K, Biankin, Andrew V, Sansom, Owen J, Morton, Jennifer P, Grey, Shane T, Cox, Thomas R, Turchini, John, Samra, Jaswinder, Clarke, Stephen J, Timpson, Paul, Gill, Anthony J, Pajic, Marina

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Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1 von Kryza, Thomas, Khan, Tashbib, Lovell, Scott, Harrington, Brittney S., Yin, Julia, Porazinski, Sean, Pajic, Marina, Koistinen, Hannu, Rantala, Juha K., Dreyer, Tobias, Magdolen, Viktor, Reuning, Ute, He, Yaowu, Tate, Edward W., Hooper, John D.

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TLR2 activation promotes tumour growth and associates with patient survival and chemotherapy response in pancreatic ductal adenocarcinoma von Lundy, Joanne, Gearing, Linden J., Gao, Hugh, West, Alison C., McLeod, Louise, Deswaerte, Virginie, Yu, Liang, Porazinski, Sean, Pajic, Marina, Hertzog, Paul J., Croagh, Daniel, Jenkins, Brendan J.

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Genome‐wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT‐ROBO, ITGA2 and MET signaling von Nones, Katia, Waddell, Nic, Song, Sarah, Patch, Ann‐Marie, Miller, David, Johns, Amber, Wu, Jianmin, Kassahn, Karin S., Wood, David, Bailey, Peter, Fink, Lynn, Manning, Suzanne, Christ, Angelika N., Nourse, Craig, Kazakoff, Stephen, Taylor, Darrin, Leonard, Conrad, Chang, David K., Jones, Marc D., Thomas, Michelle, Watson, Clare, Pinese, Mark, Cowley, Mark, Rooman, Ilse, Pajic, Marina, Butturini, Giovanni, Malpaga, Anna, Corbo, Vincenzo, Crippa, Stefano, Falconi, Massimo, Zamboni, Giuseppe, Castelli, Paola, Lawlor, Rita T., Gill, Anthony J., Scarpa, Aldo, Pearson, John V., Biankin, Andrew V., Grimmond, Sean M.

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RET gene rearrangements occur in a subset of pancreatic acinar cell carcinomas von Chou, Angela, Brown, Ian S., Kumarasinghe, M. Priyanthi, Perren, Aurel, Riley, Denise, Kim, Yoomee, Pajic, Marina, Steinmann, Angela, Rathi, Vivek, Jamieson, Nigel B., Verheij, Joanne, van Roessel, Stijn, Nahm, Chris B., Mittal, Anubhav, Samra, Jaswinder, Gill, Anthony J.

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Systematic functional identification of cancer multi-drug resistance genes von Lau, Man-Tat, Ghazanfar, Shila, Parkin, Ashleigh, Chou, Angela, Rouaen, Jourdin R, Littleboy, Jamie B, Nessem, Danielle, Khuong, Thang M, Nevoltris, Damien, Schofield, Peter, Langley, David, Christ, Daniel, Yang, Jean, Pajic, Marina, Neely, G Gregory

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Histomolecular Phenotypes and Outcome in Adenocarcinoma of the Ampulla of Vater von CHANG, David K, JAMIESON, Nigel B, NAGRIAL, Adnan M, CHANTRILL, Lorraine A, CHIN, Venessa T, PINHO, Andreia V, ROOMAN, Ilse, COWLEY, Mark J, JIANMIN WU, MEAD, R. Scott, COLVIN, Emily K, SAMRA, Jaswinder S, JOHNS, Amber L, CORBO, Vincenzo, BASSI, Claudio, FALCONI, Massimo, LAWLOR, Rita T, CRIPPA, Stefano, SPERANDIO, Nicola, BERSANI, Samantha, DICKSON, Euan J, MOHAMED, Mohamed A. A, OIEN, Karin A, SCARLETT, Christopher J, FOULIS, Alan K, MUSGROVE, Elizabeth A, SUTHERLAND, Robert L, KENCH, James G, CARTER, C. Ross, GILL, Anthony J, SCARPA, Aldo, MCKAY, Colin J, BIANKIN, Andrew V, PAJIC, Marina, CHOU, Angela, PINESE, Mark, HUMPHRIS, Jeremy L, JONES, Marc D, TOON, Christopher

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Selected Alkylating Agents Can Overcome Drug Tolerance of G0-like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice von Pajic, Marina, Blatter, Sohvi, Guyader, Charlotte, Gonggrijp, Maaike, Kersbergen, Ariena, Küçükosmanoğlu, Aslι, Sol, Wendy, Drost, Rinske, Jonkers, Jos, Borst, Piet, Rottenberg, Sven

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Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer von Conway, James R.W., Warren, Sean C., Herrmann, David, Murphy, Kendelle J., Cazet, Aurélie S., Vennin, Claire, Shearer, Robert F., Killen, Monica J., Magenau, Astrid, Mélénec, Pauline, Pinese, Mark, Nobis, Max, Zaratzian, Anaiis, Boulghourjian, Alice, Da Silva, Andrew M., del Monte-Nieto, Gonzalo, Adam, Arne S.A., Harvey, Richard P., Haigh, Jody J., Wang, Yingxiao, Croucher, David R., Sansom, Owen J., Pajic, Marina, Caldon, C. Elizabeth, Morton, Jennifer P., Timpson, Paul

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qpure: A tool to estimate tumor cellularity from genome-wide single-nucleotide polymorphism profiles von Song, Sarah, Nones, Katia, Miller, David, Harliwong, Ivon, Kassahn, Karin S, Pinese, Mark, Pajic, Marina, Gill, Anthony J, Johns, Amber L, Anderson, Matthew, Holmes, Oliver, Leonard, Conrad, Taylor, Darrin, Wood, Scott, Xu, Qinying, Newell, Felicity, Cowley, Mark J, Wu, Jianmin, Wilson, Peter, Fink, Lynn, Biankin, Andrew V, Waddell, Nic, Grimmond, Sean M, Pearson, John V

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Oral Squamous Cell Carcinoma in Young Patients Show Higher Rates of EGFR Amplification: Implications for Novel Personalized Therapy von Satgunaseelan, Laveniya, Porazinski, Sean, Strbenac, Dario, Istadi, Aji, Willet, Cali, Chew, Tracy, Sadsad, Rosemarie, Palme, Carsten E, Lee, Jenny H, Boyer, Michael, Yang, Jean Y H, Clark, Jonathan R, Pajic, Marina, Gupta, Ruta

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Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer von Rottenberg, Sven, Nygren, Anders O.H, Pajic, Marina, van Leeuwen, Fijs W.B, van der Heijden, Ingrid, van de Wetering, Koen, Liu, Xiaoling, de Visser, Karin E, Gilhuijs, Kenneth G, van Tellingen, Olaf, Schouten, Jan P, Jonkers, Jos, Borst, Piet

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Understanding pancreatic cancer genomes von Cowley, Mark J., Chang, David K., Pajic, Marina, Johns, Amber L., Waddell, Nicola, Grimmond, Sean M., Biankin, Andrew V.

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