E93 Integrates Neuroblast Intrinsic State with Developmental Time to Terminate MB Neurogenesis via Autophagy von Pahl, Matthew C., Doyle, Susan E., Siegrist, Sarah E.

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Implicating effector genes at COVID-19 GWAS loci using promoter-focused Capture-C in disease-relevant immune cell types von Pahl, Matthew C, Le Coz, Carole, Su, Chun, Sharma, Prabhat, Thomas, Rajan M, Pippin, James A, Cruz Cabrera, Emylette, Johnson, Matthew E, Leonard, Michelle E, Lu, Sumei, Chesi, Alessandra, Sullivan, Kathleen E, Romberg, Neil, Grant, Struan F A, Wells, Andrew D

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3D chromatin maps of the human pancreas reveal lineage-specific regulatory architecture of T2D risk von Su, Chun, Gao, Long, May, Catherine L, Pippin, James A, Boehm, Keith, Lee, Michelle, Liu, Chengyang, Pahl, Matthew C, Golson, Maria L, Naji, Ali, Grant, Struan F A, Wells, Andrew D, Kaestner, Klaus H

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Technologies, strategies, and cautions when deconvoluting genome‐wide association signals: FTO in focus von Pahl, Matthew C., Grant, Struan F. A., Leibel, Rudolph L., Stratigopoulos, George

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Transcriptional (ChIP-Chip) Analysis of ELF1, ETS2, RUNX1 and STAT5 in Human Abdominal Aortic Aneurysm von Pahl, Matthew C, Erdman, Robert, Kuivaniemi, Helena, Lillvis, John H, Elmore, James R, Tromp, Gerard

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3D promoter architecture re-organization during iPSC-derived neuronal cell differentiation implicates target genes for neurodevelopmental disorders von Su, Chun, Argenziano, Mariana, Lu, Sumei, Pippin, James A., Pahl, Matthew C., Leonard, Michelle E., Cousminer, Diana L., Johnson, Matthew E., Lasconi, Chiara, Wells, Andrew D., Chesi, Alessandra, Grant, Struan F.A.

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Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function von Thomas, Rajan M, Pahl, Matthew C, Wang, Liqing, Grant, Struan F A, Hancock, Wayne W, Wells, Andrew D

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Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci von Hammond, Reza K, Pahl, Matthew C, Su, Chun, Cousminer, Diana L, Leonard, Michelle E, Lu, Sumei, Doege, Claudia A, Wagley, Yadav, Hodge, Kenyaita M, Lasconi, Chiara, Johnson, Matthew E, Pippin, James A, Hankenson, Kurt D, Leibel, Rudolph L, Chesi, Alessandra, Wells, Andrew D, Grant, Struan Fa

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Implicating type 2 diabetes effector genes in relevant metabolic cellular models using promoter-focused Capture-C von Wachowski, Nicholas A., Pippin, James A., Boehm, Keith, Lu, Sumei, Leonard, Michelle E., Manduchi, Elisabetta, Parlin, Ursula W., Wabitsch, Martin, Chesi, Alessandra, Wells, Andrew D., Grant, Struan F. A., Pahl, Matthew C.

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Variant-to-gene-mapping analyses reveal a role for pancreatic islet cells in conferring genetic susceptibility to sleep-related traits von Lasconi, Chiara, Pahl, Matthew C, Pippin, James A, Su, Chun, Johnson, Matthew E, Chesi, Alessandra, Boehm, Keith, Manduchi, Elisabetta, Ou, Kristy, Golson, Maria L, Wells, Andrew D, Kaestner, Klaus H, Grant, Struan F A

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Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation von Pahl, Matthew C, Sharma, Prabhat, Thomas, Rajan M, Thompson, Zachary, Mount, Zachary, Pippin, James A, Morawski, Peter A, Sun, Peng, Su, Chun, Campbell, Daniel, Grant, Struan F A, Wells, Andrew D

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Restriction enzyme selection dictates detection range sensitivity in chromatin conformation capture-based variant-to-gene mapping approaches von Su, Chun, Pahl, Matthew C., Grant, Struan F. A., Wells, Andrew D.

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Perturbation of the insomnia WDR90 genome-wide association studies locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q von Sonti, Shilpa, Littleton, Sheridan H, Pahl, Matthew C, Zimmerman, Amber J, Chesi, Alessandra, Palermo, Justin, Lasconi, Chiara, Brown, Elizabeth B, Pippin, James A, Wells, Andrew D, Doldur-Balli, Fusun, Pack, Allan I, Gehrman, Phillip R, Keene, Alex C, Grant, Struan F A

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247-OR: Variant-to-Gene-Mapping Analyses Reveal a Role for Pancreatic Islet Cells in Conferring Genetic Susceptibility to Sleep-Related Traits von LASCONI, CHIARA, PAHL, MATTHEW C., PIPPIN, JAMES A., SU, CHUN, JOHNSON, MATTHEW, CHESI, ALESSANDRA, WELLS, ANDREW D., KAESTNER, KLAUS H., GRANT, STRUAN F.A.

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298-OR: Variant-to-Gene Mapping at the Childhood Obesity Locus on chr12q13 and Subsequent Luciferase Assay Analyses Implicate rs71329as a Causal Variant within the 3’ UTR of FAIM2... von LITTLETON, SHERIDAN H., BRADFIELD, JONATHAN, PIPPIN, JAMES A., SU, CHUN, CHESI, ALESSANDRA, WELLS, ANDREW D., BERKOWITZ, ROBERT I., PAHL, MATTHEW C., GRANT, STRUAN F.

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MicroRNA expression signature in human abdominal aortic aneurysms von Pahl, Matthew C, Derr, Kimberly, Gäbel, Gabor, Hinterseher, Irene, Elmore, James R, Schworer, Charles M, Peeler, Thomas C, Franklin, David P, Gray, John L, Carey, David J, Tromp, Gerard, Kuivaniemi, Helena

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Neuroblast niche position is controlled by Phosphoinositide 3-kinase-dependent DE-Cadherin adhesion von Doyle, Susan E, Pahl, Matthew C, Siller, Karsten H, Ardiff, Lindsay, Siegrist, Sarah E

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245-OR: CIS-Regulatory Architecture of Human ESC-Derived Hypothalamic Neuron Differentiation Aids in Variant-to-Gene Mapping of Type 2 Diabetes Related Traits von PAHL, MATTHEW C., LITTLETON, SHERIDAN H., DOEGE, CLAUDIA, HODGE, KENYAITA M., LEONARD, MICHELLE, LU, SUMEI, HAMMOND, REZA, BOEHM, KEITH, LASCONI, CHIARA, SU, CHUN, CHESI, ALESSANDRA, PIPPIN, JAMES A., JOHNSON, MATTHEW, WELLS, ANDREW D., VOIGHT, BENJAMIN F., LEIBEL, RUDOLPH, GRANT, STRUAN F., COUSMINER, DIANA L.

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CRISPR‐Cas9–Mediated Genome Editing Confirms EPDR1 as an Effector Gene at the BMD GWAS‐Implicated ‘STARD3NL’ Locus von Pippin, James A, Chesi, Alessandra, Wagley, Yadav, Su, Chun, Pahl, Matthew C, Hodge, Kenyaita M, Johnson, Matthew E, Wells, Andrew D, Hankenson, Kurt D, Grant, Struan F A

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Neuroblast niche position is controlled by Phosphoinositide 3-kinase-dependent DE-Cadherin adhesion von Doyle, Susan E., Pahl, Matthew C., Siller, Karsten H., Ardiff, Lindsay, Siegrist, Sarah E.

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