A Novel and Integrated Approach for the Identification and Characterization of Drug-induced Cardiac Toxicity in the Dog von Casartelli, Alessandro, Lanzoni, Anna, Comelli, Rodolfo, Crivellente, Federica, Defazio, Rossella, Dorigatti, Roberto, Fasdelli, Nicola, Faustinelli, Ivo, Pagliarusco, Sabrina, Tontodonati, Marcello, Cristofori, Patrizia

Volltext

Abstract 1731: EXS21546, a non-CNS penetrant A2AR-selective antagonist for anti-cancer immunotherapy von Payne, Andrew, Fons, Pierre, Alt, Isabella, van Ham, Joost, Taubert, Christina, Bell, Andy, Versluys, Stephanie, Bertrand, Florie, Visentin, Virgile, Mirey, Emilie, Pelissier, Emilie, Paillasse, Michael, Pagliarusco, Sabrina, Vladimer, Gregory, Whittaker, Mark

Volltext

Abstract 519: EVOEXS21546 is a novel non-brain penetrant A2AR inhibitor for cancer immunotherapy with accelerated drug development von Fons, Pierre, Bell, Andy, Esquerre, Michael, Versluys, Stephanie, Bertrand, Florie, Hopkins-Navratilova, Iva, Robinson, Sean, Visentin, Virgile, Schreyer, Adrian, Cox, Richard, Mirey, Emilie, Pelissier, Emilie, bergeaud, Celia, Culurgioni, Simone, Besnard, Jeremy, Payne, Andrew, Menegotto, Jerome, Machet, Frederic, Poussereau-Pomie, Celine, Cogo, Eric, Paillasse, Michael, Ferigo, Federica, Pagliarusco, Sabrina, Lisztwan, Joanna, Whittaker, Mark, Johnstone, Craig, Hopkins, Andrew

Volltext

Casopitant: In Vitro Data and SimCyp Simulation to Predict In Vivo Metabolic Interactions Involving Cytochrome P450 3A4 von MOTTA, Paola, PONS, Nicoletta, PAGLIARUSCO, Sabrina, PELLEGATTI, Mario, BONOMO, Fiorenza

Volltext

Metabolic Disposition of Casopitant, a Potent Neurokinin-1 Receptor Antagonist, in Mice, Rats, and Dogs von MIRAGLIA, Lidia, PAGLIARUSCO, Sabrina, BORDINI, Ellenia, MARTINUCCI, Silvia, PELLEGATTI, Mario

Volltext

Tissue Distribution and Characterization of Drug-Related Material in Rats and Dogs after Repeated Oral Administration of Casopitant von PAGLIARUSCO, Sabrina, MARTINUCCI, Silvia, BORDINI, Ellenia, MIRAGLIA, Lidia, CUFARI, Domenico, FERRARI, Luca, PELLEGATTI, Mario

Volltext

Effect of single and repeat doses of casopitant on the pharmacokinetics of CYP450 3A4 substrates midazolam and nifedipine von Zamuner, Stefano, Johnson, Brendan M., Pagliarusco, Sabrina, Fina, Paolo, Peroni, Michela, Fiore, Monica, Adams, Laurel M., Fernandes, Sofia A.

Volltext

Electrophoretic behavior of a highly water-soluble dendro[60]fullerene von Tamisier-Karolak, Sara-L., Pagliarusco, Sabrina, Herrenknecht, Christine, Brettreich, Michael, Hirsch, Andreas, Céolin, René, Bensasson, René V., Szwarc, Henri, Moussa, Fathi

Volltext