A Randomized Study of the Relative Pharmacokinetics, Pharmacodynamics, and Safety of Alirocumab, a Fully Human Monoclonal Antibody to PCSK9, After Single Subcutaneous Administratio... von Lunven, Catherine, Paehler, Tobias, Poitiers, Franck, Brunet, Aurélie, Rey, Jacques, Hanotin, Corinne, Sasiela, William J.

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Challenges of non-clinical safety testing for biologics: A Report of the 9th BioSafe European Annual General Membership Meeting von Kissner, Thomas, Blaich, Guenter, Baumann, Andreas, Kronenberg, Sven, Hey, Adam, Kiessling, Andrea, Schmitt, Petra M., Driessen, Wouter, Carrez, Chantal, Kramer, Daniel, Fretland, Jennifer, Richter, Wolfgang F., Paehler, Tobias, Hopfer, Ulrike, Rattel, Benno

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Relationship Between Low‐Density Lipoprotein Cholesterol, Free Proprotein Convertase Subtilisin/Kexin Type 9, and Alirocumab Levels After Different Lipid‐Lowering Strategies von Rey, Jacques, Poitiers, Franck, Paehler, Tobias, Brunet, Aurélie, DiCioccio, A. Thomas, Cannon, Christopher P., Surks, Howard K., Pinquier, Jean‐Louis, Hanotin, Corinne, Sasiela, William J.

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Biorelevant subcutaneous in vitro test predicts the release of human and fast acting insulin formulations von Schöner, Tim A., Vogel, Verena, Venczel, Marta, Knoth, Katharina, Kamm, Walter, Paehler, Tobias, Louit, Guillaume, Terán, Iria Torres, Mundinger, Patricia, Marker, Alexander, Loos, Petra, Hittinger, Marius, Lehr, Claus-Michael

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A RANDOMIZED STUDY OF THE RELATIVE BIOAVAILABILITY, PHARMACODYNAMICS, AND SAFETY OF ALIROCUMAB, A FULLY HUMAN MONOCLONAL ANTIBODY TO PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9,... von Lunven, Catherine, Paehler, Tobias, Lewanczyk, Pascale, Poitiers, Franck, Brunet, Aurelie, Rey, Jacques, Hanotin, Corinne, Sasiela, Bill

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RANDOMIZED, PARTIAL BLIND STUDY OF THE PHARMACODYNAMICS, PHARMACOKINETICS AND SAFETY OF MULTIPLE SUBCUTANEOUS DOSES OF ALIROCUMAB, A FULLY HUMAN MONOCLONAL ANTIBODY TO PROPROTEIN C... von Rey, Jacques, Poitiers, Franck, Paehler, Tobias, Brunet, Aurelie, Pinquier, Jean-Louis, Hanotin, Corinne, Sasiela, Bill

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A Randomized Study of the Relative Pharmacokinetics, Pharmacodynamics, and Safety of Alirocumab, a Fully Human Monoclonal Antibody to PCSK 9, After Single Subcutaneous Administrati... von Lunven, Catherine, Paehler, Tobias, Poitiers, Franck, Brunet, Aurélie, Rey, Jacques, Hanotin, Corinne, Sasiela, William J.

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Relationship Between Low‐Density Lipoprotein Cholesterol, Free Proprotein Convertase Subtilisin/Kexin Type 9, and Alirocumab Levels After Different Lipid‐Lowering Strategies von Rey, Jacques, Poitiers, Franck, Paehler, Tobias, Brunet, Aurélie, DiCioccio, A. Thomas, Cannon, Christopher P, Surks, Howard K, Pinquier, Jean‐Louis, Hanotin, Corinne, Sasiela, William J

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Tolerability, safety, and pharmacokinetics of the novel cathepsin A inhibitor SAR164653 in healthy subjects von Tillner, Joachim, Lehmann, Anne, Paehler, Tobias, Lukacs, Zoltan, Ruf, Sven, Sadowski, Thorsten, Pinquier, Jean-Louis, Ruetten, Hartmut

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RANDOMIZED, PARTIAL BLIND STUDY OF THE PHARMACODYNAMICS, PHARMACOKINETICS AND SAFETY OF MULTIPLE SUBCUTANEOUS DOSES OF ALIROCUMAB, A FULLY HUMAN MONOCLONAL ANTIBODY TO PROPROTEIN C... von Rey, Jacques, Poitiers, Franck, Paehler, Tobias, Brunet, Aurelie, Pinquier, Jean-Louis, Hanotin, Corinne, Sasiela, Bill

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Atrial effects of the novel K+-channel-blocker AVE0118 in anesthetized pigs von WIRTH, Klaus J, PAEHLER, Tobias, ROSENSTEIN, Bjoern, KNOBLOCH, Karsten, MAIER, Thomas, FRENZEL, Jennifer, BRENDEL, Joachim, BUSCH, Andreas E, BLEICH, Markus

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Anesthesia in pig liver transplantation for 24 hour storage using remifentanyl and ketamin: Tobias L Paehler, Martin Hertl, M. Catherine Hertl, Christoph E Broelsch, Universitätsklinikum Essen, Essen Germany

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Evidence of sinusoidal lining cell protection after pig liver transplantation: tauroursodeoxycholate leads to reduced platelet adherence: Martin Hertl, Tobias L Paehler, Antje Scheler, Olaf Dirsch, Massimo Malago, M. Catherine Hertl, Christoph E Broelsch, Universitätsklinikum Essen, Essen Germany

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Successful pig liver transplantation after 17 hours of preservation in UW solution: protective effect of tauroursodeoxycholate: Martin Hertl, Tobias L Paehler, Antje Scheler, Giuliano Testa, Lothar Volbracht, M. Catherine Hertl, Christoph E Broelsch, Universitätsklinikum Essen, Essen Germany

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2-(2-methylamino-pyrimidin-4-yl)-1h-indole-5-carboxylic acid ((s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl)-amide for use in the treatment of pain associated to osteoarthr... von Paehler, Tobias, Flechsenhar, Klaus, Grothe, Kirsten, Jan, Christelle, Lunnon, Martin

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2-(2-METHYLAMINO-PYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID [(S)-1-CARBAMOYL-2-(PHENYL-PYRIMIDIN-2-YL-AMINO)-ETHYL]-AMIDE FOR USE IN THE TREATMENT OF PAIN ASSOCIATED TO OSTEOARTHR... von JAN, CHRISTELLE, FLECHSENHAR, KLAUS, GROTHE, KIRSTEN, PAEHLER, TOBIAS, LUNNON, MARTIN

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2-(2-METHYLAMINO-PYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID [(S)-1-CARBAMOYL-2-(PHENYL-PYRIMIDIN-2-YL-AMINO)-ETHYL]-AMIDE FOR USE IN THE TREATMENT OF PAIN ASSOCIATED TO OSTEOARTHR... von PAEHLER, Tobias, GROTHE, Kirsten, JAN, Christelle, LUNNON, Martin, FLECHSENHAR, Klaus

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2-(2-METHYLAMINO-PYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID [(S)-1-CARBAMOYL-2-(PHENYL-PYRIMIDIN-2-YL-AMINO)-ETHYL]-AMIDE FOR USE IN THE TREATMENT OF PAIN ASSOCIATED TO OSTEOARTHR... von PAEHLER, Tobias, GROTHE, Kirsten, JAN, Christelle, LUNNON, Martin, FLECHSENHAR, Klaus

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2-(2-methylamino-pyrimidin-4-yl)-1h-indole-5-carboxylic acid [(S)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide for use in the treatment of pain associated to osteoarthr... von Paehler, Tobias, Flechsenhar, Klaus, Grothe, Kirsten, Jan, Christelle, Lunnon, Martin

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2-(2-METHYLAMINO-PYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID [(S)-1-CARBAMOYL-2-(PHENYL-PYRIMIDIN-2-YL-AMINO)-ETHYL]-AMIDE FOR USE IN THE TREATMENT OF PAIN ASSOCIATED TO OSTEOARTHR... von PAEHLER, Tobias, GROTHE, Kirsten, JAN, Christelle, LUNNON, Martin, FLECHSENHAR, Klaus

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