Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity von Serrels, Alan, Lund, Tom, Serrels, Bryan, Byron, Adam, McPherson, Rhoanne C., von Kriegsheim, Alexander, Gómez-Cuadrado, Laura, Canel, Marta, Muir, Morwenna, Ring, Jennifer E., Maniati, Eleni, Sims, Andrew H., Pachter, Jonathan A., Brunton, Valerie G., Gilbert, Nick, Anderton, Stephen M., Nibbs, Robert J.B., Frame, Margaret C.

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Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy von Jiang, Hong, Hegde, Samarth, Knolhoff, Brett L, Zhu, Yu, Herndon, John M, Meyer, Melissa A, Nywening, Timothy M, Hawkins, William G, Shapiro, Irina M, Weaver, David T, Pachter, Jonathan A, Wang-Gillam, Andrea, DeNardo, David G

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The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma von Begum, Asma, Ewachiw, Theodore, Jung, Clinton, Huang, Ally, Norberg, K Jessica, Marchionni, Luigi, McMillan, Ross, Penchev, Vesselin, Rajeshkumar, N V, Maitra, Anirban, Wood, Laura, Wang, Chenguang, Wolfgang, Christopher, DeJesus-Acosta, Ana, Laheru, Daniel, Shapiro, Irina M, Padval, Mahesh, Pachter, Jonathan A, Weaver, David T, Rasheed, Zeshaan A, Matsui, William

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ROCK1 and ROCK2 Are Required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion von VIGIL, Dominico, TAI YOUNG KIM, DER, Channing J, PLACHCO, Ana, GARTON, Andrew J, CASTALDO, Linda, PACHTER, Jonathan A, HANQINGDONG, XIN CHEN, TOKAR, Brianna, CAMPBELL, Sharon L

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Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib von Till, Kathleen J., Abdullah, Mariah, Alnassfan, Tahera, Janet, Gallardo Zapata, Marks, Thomas, Coma, Silvia, Weaver, David T., Pachter, Jonathan A., Pettitt, Andrew R., Slupsky, Joseph R.

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Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer von Buck, Elizabeth, Gokhale, Prafulla C, Koujak, Susan, Brown, Eric, Eyzaguirre, Alexandra, Tao, Nianjun, Rosenfeld-Franklin, Maryland, Lerner, Lorena, Chiu, M Isabel, Wild, Robert, Epstein, David, Pachter, Jonathan A, Miglarese, Mark R

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Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin von Bhagwat, Shripad V, Gokhale, Prafulla C, Crew, Andrew P, Cooke, Andy, Yao, Yan, Mantis, Christine, Kahler, Jennifer, Workman, Jennifer, Bittner, Mark, Dudkin, Lorina, Epstein, David M, Gibson, Neil W, Wild, Robert, Arnold, Lee D, Houghton, Peter J, Pachter, Jonathan A

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In vivo activity of the dual PI3Kδ and PI3Kγ inhibitor duvelisib against pediatric acute lymphoblastic leukemia xenografts von Randall, Joanna, Evans, Kathryn, Watts, Ben, Smith, Christopher M., Hughes, Keira, Earley, Eric J., Erickson, Stephen W., Pachter, Jonathan A., Teicher, Beverly A., Smith, Malcolm A., Lock, Richard B.

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PYK2/FAK inhibitors reverse hypoxia-induced drug resistance in multiple myeloma von Muz, Barbara, Buggio, Maurizio, Azab, Feda, de la Puente, Pilar, Fiala, Mark, Padval, Mahesh V, Weaver, David T, Pachter, Jonathan A, Vij, Ravi, Azab, Abdel Kareem

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MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection von Zhou, Lanlan, Huntington, Kelsey, Zhang, Shengliang, Carlsen, Lindsey, So, Eui-Young, Parker, Cassandra, Sahin, Ilyas, Safran, Howard, Kamle, Suchitra, Lee, Chang-Min, Geun Lee, Chun, A Elias, Jack, S Campbell, Kerry, T Naik, Mandar, J Atwood, Walter, Youssef, Emile, A Pachter, Jonathan, Navaraj, Arunasalam, A Seyhan, Attila, Liang, Olin, El-Deiry, Wafik S

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A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like grow... von Ji, Qun-sheng, Mulvihill, Mark J, Rosenfeld-Franklin, Maryland, Cooke, Andrew, Feng, Lixin, Mak, Gilda, O'Connor, Matthew, Yao, Yan, Pirritt, Caroline, Buck, Elizabeth, Eyzaguirre, Alexandra, Arnold, Lee D, Gibson, Neil W, Pachter, Jonathan A

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A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK von Feng, Xiaodong, Arang, Nadia, Rigiracciolo, Damiano Cosimo, Lee, Joo Sang, Yeerna, Huwate, Wang, Zhiyong, Lubrano, Simone, Kishore, Ayush, Pachter, Jonathan A., König, Gabriele M., Maggiolini, Marcello, Kostenis, Evi, Schlaepfer, David D., Tamayo, Pablo, Chen, Qianming, Ruppin, Eytan, Gutkind, J. Silvio

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Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion von Jiang, Hong, Liu, Xiuting, Knolhoff, Brett L, Hegde, Samarth, Lee, Kyung Bae, Jiang, Hongmei, Fields, Ryan C, Pachter, Jonathan A, Lim, Kian-Huat, DeNardo, David G

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PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity von Funk, Christopher Ronald, Wang, Shuhua, Chen, Kevin Z., Waller, Alexandra, Sharma, Aditi, Edgar, Claudia L., Gupta, Vikas A., Chandrakasan, Shanmuganathan, Zoine, Jaquelyn T., Fedanov, Andrew, Raikar, Sunil S., Koff, Jean L., Flowers, Christopher R., Coma, Silvia, Pachter, Jonathan A., Ravindranathan, Sruthi, Spencer, H. Trent, Shanmugam, Mala, Waller, Edmund K.

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Maintenance Defactinib Versus Placebo After First-Line Chemotherapy in Patients With Merlin-Stratified Pleural Mesothelioma: COMMAND-A Double-Blind, Randomized, Phase II Study von Fennell, Dean A, Baas, Paul, Taylor, Paul, Nowak, Anna K, Gilligan, David, Nakano, Takashi, Pachter, Jonathan A, Weaver, David T, Scherpereel, Arnaud, Pavlakis, Nick, van Meerbeeck, Jan P, Cedrés, Susana, Nolan, Luke, Kindler, Hedy, Aerts, Joachim G J V

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Inhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti–IGF-IR antibody von Wang, Yan, Hailey, Judith, Williams, Denise, Wang, Yaolin, Lipari, Philip, Malkowski, Michael, Wang, Xiaoying, Xie, Lei, Li, Guanghua, Saha, Deba, Ling, Wai Lam W, Cannon-Carlson, Susan, Greenberg, Robert, Ramos, Robert A, Shields, Robert, Presta, Leonard, Brams, Peter, Bishop, W Robert, Pachter, Jonathan A

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Dual Stromal Targeting Sensitizes Pancreatic Adenocarcinoma for Anti-Programmed Cell Death Protein 1 Therapy von Blair, Alex B., Wang, Jianxin, Davelaar, John, Baker, Andrew, Li, Keyu, Niu, Nan, Wang, Junke, Shao, Yingkuan, Funes, Vanessa, Li, Pan, Pachter, Jonathan A., Maneval, Daniel C., Dezem, Felipe, Plummer, Jasmine, Chan, Keith Syson, Gong, Jun, Hendifar, Andrew E., Pandol, Stephen J., Burkhart, Richard, Zhang, Yuqing, Zheng, Lei, Osipov, Arsen

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Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ -Driven Uveal Melanoma von Paradis, Justine S, Acosta, Monica, Saddawi-Konefka, Robert, Kishore, Ayush, Gomes, Frederico, Arang, Nadia, Tiago, Manoela, Coma, Silvia, Lubrano, Simone, Wu, Xingyu, Ford, Kyle, Day, Chi-Ping, Merlino, Glenn, Mali, Prashant, Pachter, Jonathan A, Sato, Takami, Aplin, Andrew E, Gutkind, J Silvio

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Synergistic efficacy of the dual PI3K-δ/γ inhibitor duvelisib with the Bcl-2 inhibitor venetoclax in Richter syndrome PDX models von Iannello, Andrea, Vitale, Nicoletta, Coma, Silvia, Arruga, Francesca, Chadburn, Amy, Di Napoli, Arianna, Laudanna, Carlo, Allan, John N., Furman, Richard R., Pachter, Jonathan A., Deaglio, Silvia, Vaisitti, Tiziana

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Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis von Ozmadenci, Duygu, Shankara Narayanan, Jayanth S, Andrew, Jacob, Ojalill, Marjaana, Barrie, Allison M, Jiang, Shulin, Iyer, Samhita, Chen, Xiao Lei, Rose, Michael, Estrada, Valeria, Molinolo, Alfredo, Bertotto, Thomas, Mikulski, Zbigniew, McHale, Michael C, White, Rebekah R, Connolly, Denise C, Pachter, Jonathan A, Kuchroo, Vijay K, Stupack, Dwayne G, Schlaepfer, David D

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