Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity von Serrels, Alan, Lund, Tom, Serrels, Bryan, Byron, Adam, McPherson, Rhoanne C., von Kriegsheim, Alexander, Gómez-Cuadrado, Laura, Canel, Marta, Muir, Morwenna, Ring, Jennifer E., Maniati, Eleni, Sims, Andrew H., Pachter, Jonathan A., Brunton, Valerie G., Gilbert, Nick, Anderton, Stephen M., Nibbs, Robert J.B., Frame, Margaret C.

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Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy von Jiang, Hong, Hegde, Samarth, Knolhoff, Brett L, Zhu, Yu, Herndon, John M, Meyer, Melissa A, Nywening, Timothy M, Hawkins, William G, Shapiro, Irina M, Weaver, David T, Pachter, Jonathan A, Wang-Gillam, Andrea, DeNardo, David G

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The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma von Begum, Asma, Ewachiw, Theodore, Jung, Clinton, Huang, Ally, Norberg, K Jessica, Marchionni, Luigi, McMillan, Ross, Penchev, Vesselin, Rajeshkumar, N V, Maitra, Anirban, Wood, Laura, Wang, Chenguang, Wolfgang, Christopher, DeJesus-Acosta, Ana, Laheru, Daniel, Shapiro, Irina M, Padval, Mahesh, Pachter, Jonathan A, Weaver, David T, Rasheed, Zeshaan A, Matsui, William

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A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK von Feng, Xiaodong, Arang, Nadia, Rigiracciolo, Damiano Cosimo, Lee, Joo Sang, Yeerna, Huwate, Wang, Zhiyong, Lubrano, Simone, Kishore, Ayush, Pachter, Jonathan A., König, Gabriele M., Maggiolini, Marcello, Kostenis, Evi, Schlaepfer, David D., Tamayo, Pablo, Chen, Qianming, Ruppin, Eytan, Gutkind, J. Silvio

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Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion von Jiang, Hong, Liu, Xiuting, Knolhoff, Brett L, Hegde, Samarth, Lee, Kyung Bae, Jiang, Hongmei, Fields, Ryan C, Pachter, Jonathan A, Lim, Kian-Huat, DeNardo, David G

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PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity von Funk, Christopher Ronald, Wang, Shuhua, Chen, Kevin Z., Waller, Alexandra, Sharma, Aditi, Edgar, Claudia L., Gupta, Vikas A., Chandrakasan, Shanmuganathan, Zoine, Jaquelyn T., Fedanov, Andrew, Raikar, Sunil S., Koff, Jean L., Flowers, Christopher R., Coma, Silvia, Pachter, Jonathan A., Ravindranathan, Sruthi, Spencer, H. Trent, Shanmugam, Mala, Waller, Edmund K.

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Maintenance Defactinib Versus Placebo After First-Line Chemotherapy in Patients With Merlin-Stratified Pleural Mesothelioma: COMMAND-A Double-Blind, Randomized, Phase II Study von Fennell, Dean A, Baas, Paul, Taylor, Paul, Nowak, Anna K, Gilligan, David, Nakano, Takashi, Pachter, Jonathan A, Weaver, David T, Scherpereel, Arnaud, Pavlakis, Nick, van Meerbeeck, Jan P, Cedrés, Susana, Nolan, Luke, Kindler, Hedy, Aerts, Joachim G J V

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Dual Stromal Targeting Sensitizes Pancreatic Adenocarcinoma for Anti-Programmed Cell Death Protein 1 Therapy von Blair, Alex B., Wang, Jianxin, Davelaar, John, Baker, Andrew, Li, Keyu, Niu, Nan, Wang, Junke, Shao, Yingkuan, Funes, Vanessa, Li, Pan, Pachter, Jonathan A., Maneval, Daniel C., Dezem, Felipe, Plummer, Jasmine, Chan, Keith Syson, Gong, Jun, Hendifar, Andrew E., Pandol, Stephen J., Burkhart, Richard, Zhang, Yuqing, Zheng, Lei, Osipov, Arsen

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Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ -Driven Uveal Melanoma von Paradis, Justine S, Acosta, Monica, Saddawi-Konefka, Robert, Kishore, Ayush, Gomes, Frederico, Arang, Nadia, Tiago, Manoela, Coma, Silvia, Lubrano, Simone, Wu, Xingyu, Ford, Kyle, Day, Chi-Ping, Merlino, Glenn, Mali, Prashant, Pachter, Jonathan A, Sato, Takami, Aplin, Andrew E, Gutkind, J Silvio

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ROCK1 and ROCK2 Are Required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion von VIGIL, Dominico, TAI YOUNG KIM, DER, Channing J, PLACHCO, Ana, GARTON, Andrew J, CASTALDO, Linda, PACHTER, Jonathan A, HANQINGDONG, XIN CHEN, TOKAR, Brianna, CAMPBELL, Sharon L

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Synergistic efficacy of the dual PI3K-δ/γ inhibitor duvelisib with the Bcl-2 inhibitor venetoclax in Richter syndrome PDX models von Iannello, Andrea, Vitale, Nicoletta, Coma, Silvia, Arruga, Francesca, Chadburn, Amy, Di Napoli, Arianna, Laudanna, Carlo, Allan, John N., Furman, Richard R., Pachter, Jonathan A., Deaglio, Silvia, Vaisitti, Tiziana

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Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib von Till, Kathleen J., Abdullah, Mariah, Alnassfan, Tahera, Janet, Gallardo Zapata, Marks, Thomas, Coma, Silvia, Weaver, David T., Pachter, Jonathan A., Pettitt, Andrew R., Slupsky, Joseph R.

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In vivo activity of the dual PI3Kδ and PI3Kγ inhibitor duvelisib against pediatric acute lymphoblastic leukemia xenografts von Randall, Joanna, Evans, Kathryn, Watts, Ben, Smith, Christopher M., Hughes, Keira, Earley, Eric J., Erickson, Stephen W., Pachter, Jonathan A., Teicher, Beverly A., Smith, Malcolm A., Lock, Richard B.

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Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer von Buck, Elizabeth, Gokhale, Prafulla C, Koujak, Susan, Brown, Eric, Eyzaguirre, Alexandra, Tao, Nianjun, Rosenfeld-Franklin, Maryland, Lerner, Lorena, Chiu, M Isabel, Wild, Robert, Epstein, David, Pachter, Jonathan A, Miglarese, Mark R

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Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis von Ozmadenci, Duygu, Shankara Narayanan, Jayanth S, Andrew, Jacob, Ojalill, Marjaana, Barrie, Allison M, Jiang, Shulin, Iyer, Samhita, Chen, Xiao Lei, Rose, Michael, Estrada, Valeria, Molinolo, Alfredo, Bertotto, Thomas, Mikulski, Zbigniew, McHale, Michael C, White, Rebekah R, Connolly, Denise C, Pachter, Jonathan A, Kuchroo, Vijay K, Stupack, Dwayne G, Schlaepfer, David D

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PI3K/mTOR dual inhibitor VS-5584 preferentially targets cancer stem cells von Kolev, Vihren N, Wright, Quentin G, Vidal, Christian M, Ring, Jennifer E, Shapiro, Irina M, Ricono, Jill, Weaver, David T, Padval, Mahesh V, Pachter, Jonathan A, Xu, Qunli

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Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin von Bhagwat, Shripad V, Gokhale, Prafulla C, Crew, Andrew P, Cooke, Andy, Yao, Yan, Mantis, Christine, Kahler, Jennifer, Workman, Jennifer, Bittner, Mark, Dudkin, Lorina, Epstein, David M, Gibson, Neil W, Wild, Robert, Arnold, Lee D, Houghton, Peter J, Pachter, Jonathan A

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Combinatorial Inhibition of Focal Adhesion Kinase and BCL-2 Enhances Antileukemia Activity of Venetoclax in Acute Myeloid Leukemia von Wang, Xiangmeng, Mak, Po Yee, Mu, Hong, Tao, Wenjing, Rao, Arvind, Visweswaran, Ravikumar, Ruvolo, Vivian, Pachter, Jonathan A, Weaver, David T, Andreeff, Michael, Xu, Bing, Carter, Bing Z

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Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Xenograft Model von Chen, Shih-Shih, Barrientos, Jacqueline C, Ferrer, Gerardo, King-Richards, Morgan, Chen, Yu-Ju, Ravichandran, Priyadarshini, Ibrahim, Michael, Kieso, Yasmine, Waters, Sheila, Kutok, Jeffery L, Peluso, Marisa, Sharma, Sujata, Weaver, David T, Pachter, Jonathan A, Rai, Kanti R, Chiorazzi, Nicholas

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Preclinical efficacy of RAF/MEK clamp avutometinib in combination with FAK inhibition in low grade serous ovarian cancer von McNamara, Blair, Demirkiran, Cem, Hartwich, Tobias Max Philipp, Bellone, Stefania, Manavella, Diego, Mutlu, Levent, Greenman, Michelle, Zipponi, Margherita, Yang-Hartwich, Yang, Yang, Kevin, Ratner, Elena, Schwartz, Peter E., Coma, Silvia, Pachter, Jonathan A., Santin, Alessandro D.

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