Natural products as modulators of eukaryotic protein secretion von Luesch, Hendrik, Paavilainen, Ville O

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Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel von Paatero, Anja O., Kellosalo, Juho, Dunyak, Bryan M., Almaliti, Jehad, Gestwicki, Jason E., Gerwick, William H., Taunton, Jack, Paavilainen, Ville O.

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The subset of peroxisomal tail-anchored proteins do not reach peroxisomes via ER, instead mitochondria can be involved von Somborac, Tamara, Lutfullahoglu Bal, Güleycan, Fatima, Kaneez, Vihinen, Helena, Paatero, Anja, Jokitalo, Eija, Paavilainen, Ville O, Konovalova, Svetlana

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TSignal: a transformer model for signal peptide prediction von Dumitrescu, Alexandru, Jokinen, Emmi, Paatero, Anja, Kellosalo, Juho, Paavilainen, Ville O, Lähdesmäki, Harri

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Mycolactone subverts immunity by selectively blocking the Sec61 translocon von Baron, Ludivine, Paatero, Anja Onerva, Morel, Jean-David, Impens, Francis, Guenin-Macé, Laure, Saint-Auret, Sarah, Blanchard, Nicolas, Dillmann, Rabea, Niang, Fatoumata, Pellegrini, Sandra, Taunton, Jack, Paavilainen, Ville O, Demangel, Caroline

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Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation von Zong, Guanghui, Hu, Zhijian, O’Keefe, Sarah, Tranter, Dale, Iannotti, Michael J, Baron, Ludivine, Hall, Belinda, Corfield, Katherine, Paatero, Anja O, Henderson, Mark J, Roboti, Peristera, Zhou, Jianhong, Sun, Xianwei, Govindarajan, Mugunthan, Rohde, Jason M, Blanchard, Nicolas, Simmonds, Rachel, Inglese, James, Du, Yuchun, Demangel, Caroline, High, Stephen, Paavilainen, Ville O, Shi, Wei Q

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Electrophilic Fragment-Based Design of Reversible Covalent Kinase Inhibitors von Miller, Rand M, Paavilainen, Ville O, Krishnan, Shyam, Serafimova, Iana M, Taunton, Jack

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Snapshots of actin and tubulin folding inside the TRiC chaperonin von Kelly, John J., Tranter, Dale, Pardon, Els, Chi, Gamma, Kramer, Holger, Happonen, Lotta, Knee, Kelly M., Janz, Jay M., Steyaert, Jan, Bulawa, Christine, Paavilainen, Ville O., Huiskonen, Juha T., Yue, Wyatt W.

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Signal peptide mimicry primes Sec61 for client-selective inhibition von Rehan, Shahid, Tranter, Dale, Sharp, Phillip P., Craven, Gregory B., Lowe, Eric, Anderl, Janet L., Muchamuel, Tony, Abrishami, Vahid, Kuivanen, Suvi, Wenzell, Nicole A., Jennings, Andy, Kalyanaraman, Chakrapani, Strandin, Tomas, Javanainen, Matti, Vapalahti, Olli, Jacobson, Matthew P., McMinn, Dustin, Kirk, Christopher J., Huiskonen, Juha T., Taunton, Jack, Paavilainen, Ville O.

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Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature von Morel, Jean-David, Paatero, Anja O., Wei, Jiajie, Yewdell, Jonathan W., Guenin-Macé, Laure, Van Haver, Delphi, Impens, Francis, Pietrosemoli, Natalia, Paavilainen, Ville O., Demangel, Caroline

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Functional reconstitution of human equilibrative nucleoside transporter-1 into styrene maleic acid co-polymer lipid particles von Rehan, Shahid, Paavilainen, Ville O., Jaakola, Veli-Pekka

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Missing-in-metastasis and IRSp53 deform PI(4,5)P₂-rich membranes by an inverse BAR domain-like mechanism von Mattila, Pieta K, Pykäläinen, Anette, Saarikangas, Juha, Paavilainen, Ville O, Vihinen, Helena, Jokitalo, Eija, Lappalainen, Pekka

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Wherever I may roam: organellar protein targeting and evolvability von Dunn, Cory D, Paavilainen, Ville O

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Prolonged and tunable residence time using reversible covalent kinase inhibitors von Bradshaw, J Michael, McFarland, Jesse M, Paavilainen, Ville O, Bisconte, Angelina, Tam, Danny, Phan, Vernon T, Romanov, Sergei, Finkle, David, Shu, Jin, Patel, Vaishali, Ton, Tony, Li, Xiaoyan, Loughhead, David G, Nunn, Philip A, Karr, Dane E, Gerritsen, Mary E, Funk, Jens Oliver, Owens, Timothy D, Verner, Erik, Brameld, Ken A, Hill, Ronald J, Goldstein, David M, Taunton, Jack

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Rapamycin-inspired macrocycles with new target specificity von Guo, Zufeng, Hong, Sam Y., Wang, Jingxin, Rehan, Shahid, Liu, Wukun, Peng, Hanjing, Das, Manisha, Li, Wei, Bhat, Shridhar, Peiffer, Brandon, Ullman, Brett R., Tse, Chung-Ming, Tarmakova, Zlatina, Schiene-Fischer, Cordelia, Fischer, Gunter, Coe, Imogen, Paavilainen, Ville O., Sun, Zhaoli, Liu, Jun O.

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Structure of the actin-depolymerizing factor homology domain in complex with actin von Paavilainen, Ville O, Oksanen, Esko, Goldman, Adrian, Lappalainen, Pekka

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Targeting of HER/ErbB family proteins using broad spectrum Sec61 inhibitors coibamide A and apratoxin A von Kazemi, Soheila, Kawaguchi, Shinsaku, Badr, Christian E., Mattos, Daphne R., Ruiz-Saenz, Ana, Serrill, Jeffrey D., Moasser, Mark M., Dolan, Brian P., Paavilainen, Ville O., Oishi, Shinya, McPhail, Kerry L., Ishmael, Jane E.

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Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins von Tranter, Dale, Paatero, Anja O, Kawaguchi, Shinsaku, Kazemi, Soheila, Serrill, Jeffrey D, Kellosalo, Juho, Vogel, Walter K, Richter, Uwe, Mattos, Daphne R, Wan, Xuemei, Thornburg, Christopher C, Oishi, Shinya, McPhail, Kerry L, Ishmael, Jane E, Paavilainen, Ville O

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An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate von Mackinnon, Andrew L, Paavilainen, Ville O, Sharma, Ajay, Hegde, Ramanujan S, Taunton, Jack

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Kendomycin Cytotoxicity against Bacterial, Fungal, and Mammalian Cells Is Due to Cation Chelation von Tranter, Dale, Filipuzzi, Ireos, Lochmann, Thomas, Knapp, Britta, Kellosalo, Juho, Estoppey, David, Pistorius, Dominik, Meissner, Axel, Paavilainen, Ville O, Hoepfner, Dominic

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