Unlocking methodological insights on oncology efficacy endpoints: from statistical to clinical and vice versa. Letter to the editor regarding ‘Abemaciclib plus a nonsteroidal aromatase inhibitor as initial therapy for HR+, HER2− advanced breast cancer: final overall survival results of MONARCH 3’ by M. P. Goetz et al von De Sanctis, R., Bruzzi, P., Zambelli, A.

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Surrogate endpoints for EDSS worsening in multiple sclerosis: A meta-analytic approach von SORMANI, M. P, BONZANO, L, ROCCATAGLIATA, L, MANCARDI, G. L, UCCELLI, A, BRUZZI, P

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Endocrine and metabolic complications in children and adolescents with Sickle Cell Disease: an Italian cohort study von Mandese, V, Bigi, E, Bruzzi, P, Palazzi, G, Predieri, B, Lucaccioni, L, Cellini, M, Iughetti, L

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Mortality after bloodstream infections in allogeneic haematopoietic stem cell transplant (HSCT) recipients von Mikulska, M., Del Bono, V., Bruzzi, P., Raiola, A. M., Gualandi, F., Van Lint, M. T., Bacigalupo, A., Viscoli, C.

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Difficulties in conducting pure academic research, obstacles in data collection and quality of informations: The example of the INTERCEPTOR study von Merlano, M, Denaro, N, Benasso, M, Licitra, L, Bossi, P, Locati, L, Vecchio, S, Bruzzi, P

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Role of micronucleus test in predicting breast cancer susceptibility: a systematic review and meta-analysis von Cardinale, F, Bruzzi, P, Bolognesi, C

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Initial serum (1,3)-β-d-glucan as a predictor of mortality in proven candidaemia: findings from a retrospective study in two teaching hospitals in Italy and Brazil von Giacobbe, D.R., Esteves, P., Bruzzi, P., Mikulska, M., Furfaro, E., Mesini, A., Tatarelli, P., Grignolo, S., Viscoli, C., Colombo, A.L., Del Bono, V.

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Survival of metastatic breast carcinoma patients over : A 20-year period a retrospective analysis based on individual patient data from six consecutive studies von GENNARI, Alessandra, CONTE, Pierfranco, ROSSO, Riccardo, ORLANDINI, Cinzia, BRUZZI, Paolo

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Ovarian suppression using luteinizing hormone-releasing hormone agonists during chemotherapy to preserve ovarian function and fertility of breast cancer patients: a meta-analysis o... von Lambertini, M., Ceppi, M., Poggio, F., Peccatori, F.A., Azim, H.A., Ugolini, D., Pronzato, P., Loibl, S., Moore, H.C.F., Partridge, A.H., Bruzzi, P., Del Mastro, L.

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210 Genetic and epigenetic factors affect RET gene expression in breast cancer cell lines and influence survival in patients von Griseri, P, Garrone, O, Lo Sardo, A, Monteverde, M, Rusmini, M, Tonissi, F, Merlano, M, Bruzzi, P, Ceccherini, I, Nigro, C. Lo

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Metformin plus chemotherapy versus chemotherapy alone in the first-line treatment of HER2-negative metastatic breast cancer. The MYME randomized, phase 2 clinical trial von Nanni, O., Amadori, D., De Censi, A., Rocca, A., Freschi, A., Bologna, A., Gianni, L., Rosetti, F., Amaducci, L., Cavanna, L., Foca, F., Sarti, S., Serra, P., Valmorri, L., Bruzzi, P., Corradengo, D., Gennari, A.

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A risk score model predictive of the presence of additional disease in the axilla in early-breast cancer patients with one or two metastatic sentinel lymph nodes von Canavese, G, Bruzzi, P, Catturich, A, Vecchio, C, Tomei, D, Del Mastro, L, Carli, F, Guenzi, M, Lacopo, F, Dozin, B

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Initial serum (1,3)- beta -d-glucan as a predictor of mortality in proven candidaemia: findings from a retrospective study in two teaching hospitals in Italy and Brazil: Mycology von Giacobbe, DR, Esteves, P, Bruzzi, P, Mikulska, M, Furfaro, E, Mesini, A, Tatarelli, P, Grignolo, S, Viscoli, C, Colombo, AL, Del Bono, V

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Combined MRI lesions and relapses as a surrogate for disability in multiple sclerosis von SORMANI, M. P, LI, D. K, BRUZZI, P, STUBINSKI, B, CORNELISSE, P, ROCAK, S, DE STEFANO, N

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Intra-operative evaluation of the sentinel lymph node for T1-N0 breast-cancer patients: Always or never? A risk/benefit and cost/benefit analysis von Canavese, G, Bruzzi, P, Catturich, A, Vecchio, C, Tomei, D, Carli, F, Truini, M, Andreoli, G.B, Priano, V, Dozin, B

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Rare Cancers Europe (RCE) methodological recommendations for clinical studies in rare cancers: a European consensus position paper von Casali, P.G., Bruzzi, P., Bogaerts, J., Blay, J.-Y., Aapro, M., Adamous, A., Berruti, A., Blay, J.-Y., Bogaerts, J., Bressington, J., Bruzzi, B., Capocaccia, R., Cardoso, F., Casali, P.G., Celis, J.E., Cervantes, A., Ciardiello, F., Claussen, C., Coleman, M., Comis, S., Craine, S., De Boltz, D., De Lorenzo, F., Dei Tos, A.P., Gatta, G., Geissler, J., Giuliani, R., Grande, E., Gronchi, A., Jezdic, S., Jonsson, B., Jost, L., Keulen, H., Lacombe, D., Lamory, G., Le Cam, Y., Leto di Priolo, S., Licitra, L., Macchia, F., Margulies, A., Marreaud, S., McVie, G., Narbutas, S., Oliver, K., Pavlidis, N., Pelouchova, J., Pentheroudakis, G., Piccart, M., Pierotti, M.A., Pravettoni, G., Redmond, K., Riegman, P., Ruffilli, M.P., Ryner, D., Sandrucci, S., Seymour, M., Torri, V., Trama, A., Van Belle, S., Vassal, G., Wartenberg, M., Watts, C., Wilson, A., Yared, W.

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Why are Cochrane hepato-biliary reviews undervalued by physicians as an aid for clinical decision-making? von Pagliaro, L, Bruzzi, P, Bobbio, M

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Sentinel node biopsy compared with complete axillary dissection for staging early breast cancer with clinically negative lymph nodes: results of randomized trial von Canavese, G., Catturich, A., Vecchio, C., Tomei, D., Gipponi, M., Villa, G., Carli, F., Bruzzi, P., Dozin, B.

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HM35 Role of temporary ovarian suppression obtained with GnRH analogue in reducing premature ovarian failure induced by chemotherapy in premenopausal cancer patients: a meta-analys... von Lambertini, M, Bruzzi, P, Levaggi, A, Poggio, F, D'Alonzo, A, Giraudi, S, Bighin, C, Pronzato, P, Mastro, L. Del

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Previous bloodstream infections due to other pathogens as predictors of carbapenem-resistant Klebsiella pneumoniae bacteraemia in colonized patients: results from a retrospective m... von Giacobbe, D. R., Del Bono, V., Bruzzi, P., Corcione, S., Giannella, M., Marchese, A., Magnasco, L., Maraolo, A. E., Pagani, N., Saffioti, C., Ambretti, S., Cardellino, C. S., Coppo, E., De Rosa, F. G., Viale, P., Viscoli, C.

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