Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy von Cleary, Michael L, Wang, Zhong, Smith, Kevin S, Murphy, Mark, Piloto, Obdulio, Somervaille, Tim C. P

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Identification of curaxin as a potential new therapeutic for JAK2 V617F mutant patients von Pearson, Stella, Blance, Rognvald, Yan, Fei, Hsieh, Ya-Ching, Geary, Bethany, Amaral, Fabio M R, Somervaille, Tim C P, Kirschner, Kristina, Whetton, Anthony D, Pierce, Andrew

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Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells von SOMERVAILLE, Tim C. P, MATHENY, Christina J, SPENCER, Gary J, IWASAKI, Masayuki, RINN, John L, WITTEN, Daniela M, CHANG, Howard Y, SHURTLEFF, Sheila A, DOWNING, James R, CLEARY, Michael L

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Blast cells surviving acute myeloid leukemia induction therapy are in cycle with a signature of FOXM1 activity von Williams, Mark S., Basma, Naseer J., Amaral, Fabio M. R., Wiseman, Daniel H., Somervaille, Tim C. P.

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Targeted nanopore sequencing for the identification of ABCB1 promoter translocations in cancer von Williams, Mark S., Basma, Naseer J., Amaral, Fabio M. R., Williams, Gillian, Weightman, John P., Breitwieser, Wolfgang, Nelson, Louisa, Taylor, Stephen S., Wiseman, Daniel H., Somervaille, Tim C. P.

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Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis von Yoshimi, Akihide, Lin, Kuan-Ting, Wiseman, Daniel H., Rahman, Mohammad Alinoor, Pastore, Alessandro, Wang, Bo, Lee, Stanley Chun-Wei, Micol, Jean-Baptiste, Zhang, Xiao Jing, de Botton, Stephane, Penard-Lacronique, Virginie, Stein, Eytan M., Cho, Hana, Miles, Rachel E., Inoue, Daichi, Albrecht, Todd R., Somervaille, Tim C. P., Batta, Kiran, Amaral, Fabio, Simeoni, Fabrizio, Wilks, Deepti P., Cargo, Catherine, Intlekofer, Andrew M., Levine, Ross L., Dvinge, Heidi, Bradley, Robert K., Wagner, Eric J., Krainer, Adrian R., Abdel-Wahab, Omar

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LSD1: biologic roles and therapeutic targeting von Maiques-Diaz, Alba, Somervaille, Tim CP

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Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability von White, Daniel J, Unwin, Richard D, Bindels, Eric, Pierce, Andrew, Teng, Hsiang-Ying, Muter, Joanne, Greystoke, Brigit, Somerville, Tim D, Griffiths, John, Lovell, Simon, Somervaille, Tim C P, Delwel, Ruud, Whetton, Anthony D, Meyer, Stefan

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A retrospective real-world study of the current treatment pathways for myelofibrosis in the United Kingdom: the REALISM UK study von Mead, Adam J., Butt, Nauman M., Nagi, Waseem, Whiteway, Alastair, Kirkpatrick, Suriya, Rinaldi, Ciro, Roughley, Catherine, Ackroyd, Sam, Ewing, Joanne, Neelakantan, Pratap, Garg, Mamta, Tucker, David, Murphy, John, Patel, Hitesh, Bains, Rozinder, Chiu, Gavin, Hickey, Joe, Harrison, Claire, Somervaille, Tim C. P.

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Emerging Epigenetic Therapeutic Targets in Acute Myeloid Leukemia von Wingelhofer, Bettina, Somervaille, Tim C P

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KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease von Maes, Tamara, Mascaró, Cristina, Ortega, Alberto, Lunardi, Serena, Ciceri, Filippo, Somervaille, Tim C P, Buesa, Carlos

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Response to tyrosine kinase inhibitors in myeloid neoplasms associated with PCM1‐JAK2, BCR‐JAK2 and ETV6‐ABL1 fusion genes von Schwaab, Juliana, Naumann, Nicole, Luebke, Johannes, Jawhar, Mohamad, Somervaille, Tim C.P., Williams, Mark S., Frewin, Rebecca, Jost, Philipp J., Lichtenegger, Felix S., La Rosée, Paul, Storch, Nicola, Haferlach, Torsten, Horny, Hans‐Peter, Fabarius, Alice, Haferlach, Claudia, Burchert, Andreas, Hofmann, Wolf‐Karsten, Cross, Nicholas C.P., Hochhaus, Andreas, Reiter, Andreas, Metzgeroth, Georgia

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Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6 von Liedtke, Michaela, Ayton, Paul M., Somervaille, Tim C.P., Smith, Kevin S., Cleary, Michael L.

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Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML von Nicosia, Luciano, Boffo, Francesca Ludovica, Ceccacci, Elena, Conforti, Fabio, Pallavicini, Isabella, Bedin, Fabio, Ravasio, Roberto, Massignani, Enrico, Somervaille, Tim C. P., Minucci, Saverio, Bonaldi, Tiziana

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Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells? von Somervaille, Tim C. P., Cleary, Michael L.

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Divergent clonal evolution of blastic plasmacytoid dendritic cell neoplasm and chronic myelomonocytic leukemia from a shared TET2-mutated origin von Batta, Kiran, Bossenbroek, Hasse M., Pemmaraju, Naveen, Wilks, Deepti P., Chasty, Richard, Dennis, Mike, Milne, Paul, Collin, Matthew, Beird, Hannah C., Taylor, Justin, Patnaik, Mrinal M., Cargo, Catherine A., Somervaille, Tim C. P., Wiseman, Daniel H.

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Chronic myeloid leukemia presenting as compartment syndrome with acute loss of upper limb function von D'Souza, Natasha, Somervaille, Tim C.P., Mowatt, David J.

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Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia von Somervaille, Tim C.P., Cleary, Michael L.

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Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia von Deb, Gauri, Wingelhofer, Bettina, Amaral, Fabio M. R., Maiques-Diaz, Alba, Chadwick, John A., Spencer, Gary J., Williams, Emma L., Leong, Hui-Sun, Maes, Tamara, Somervaille, Tim C. P.

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The miR-17-92 microRNA Polycistron Regulates MLL Leukemia Stem Cell Potential by Modulating p21 Expression von PIU WONG, IWASAKI, Masayuki, SOMERVAILLE, Tim C. P, FICARA, Francesca, CARICO, Christine, ARNOLD, Christopher, CHEN, Chang-Zheng, CLEARY, Michael L

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