Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function von Riopel, Matthew, Seo, Jong Bae, Bandyopadhyay, Gautam K, Li, Pingping, Wollam, Joshua, Chung, Heekyung, Jung, Seung-Ryoung, Murphy, Anne, Wilson, Maria, de Jong, Ron, Patel, Sanjay, Balakrishna, Deepika, Bilakovics, James, Fanjul, Andrea, Plonowski, Artur, Koh, Duk-Su, Larson, Christopher J, Olefsky, Jerrold M, Lee, Yun Sok

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The Selective PI3K Inhibitor XL147 (SAR245408) Inhibits Tumor Growth and Survival and Potentiates the Activity of Chemotherapeutic Agents in Preclinical Tumor Models von Foster, Paul, Yamaguchi, Kyoko, Hsu, Pin P, Qian, Fawn, Du, Xiangnan, Wu, Jianming, Won, Kwang-Ai, Yu, Peiwen, Jaeger, Christopher T, Zhang, Wentao, Marlowe, Charles K, Keast, Paul, Abulafia, Wendy, Chen, Jason, Young, Jenny, Plonowski, Artur, Yakes, F Michael, Chu, Felix, Engell, Kelly, Bentzien, Frauke, Lam, Sanh T, Dale, Stephanie, Yturralde, Olivia, Matthews, David J, Lamb, Peter, Laird, A Douglas

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Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design—Part 2 von McBride, Christopher, Cheruvallath, Zacharia, Komandla, Mallareddy, Tang, Mingnam, Farrell, Pamela, Lawson, J. David, Vanderpool, Darin, Wu, Yiqin, Dougan, Douglas R., Plonowski, Artur, Holub, Corine, Larson, Chris

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CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice von Riopel, Matthew, Vassallo, Melanie, Ehinger, Erik, Pattison, Jennifer, Bowden, Karen, Winkels, Holger, Wilson, Maria, de Jong, Ron, Patel, Sanjay, Balakrishna, Deepika, Bilakovics, James, Fanjul, Andrea, Plonowski, Artur, Larson, Christopher J., Ley, Klaus, Cabrales, Pedro, Witztum, Joseph L., Olefsky, Jerrold M., Lee, Yun Sok

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TOP-156 SRT-015: Novel therapeutic for cholestatic liver diseases von Elias, Kathleen, Brown, S. David, McDonnell, Neil D., Plonowski, Artur

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FRI-528 - Development of physiologically based pharmacokinetic model to predict liver exposure of SRT-015, a next-generation inhibitor of apoptosis signal-regulating kinase 1 von Plonowski, Artur, Burge, Daniel, Elias, Kathleen, McDonnell, Neil D.

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Development of physiologically based pharmacokinetic model to predict liver exposure of SRT-015, a next-generation inhibitor of apoptosis signal-regulating kinase 1 von Plonowski, Artur, Burge, Daniel, Elias, Kathleen, McDonnell, Neil D.

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Abstract 13724: Development of VS-041 as a Precision Medicine Targeting Cardiac-Relevant Matrix Metalloproteases (MMPs) in Heart Failure With Preserved Ejection Fraction (HFpEF) von Plonowski, Artur, Pratt, Benjamin, Krupa, Magdalena, Lipinski, Piotr, Herbert, Mark

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Stability of Cytotoxic Luteinizing Hormone-Releasing Hormone Conjugate (AN-152) Containing Doxorubicin 14-O-Hemiglutarate in Mouse and Human Serum in vitro: Implications for the De... von Nagy, Attila, Plonowski, Artur, Schally, Andrew V.

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Abstract 4137688: Inhibition of Cardiac Fibrosis and Pro-Fibrotic Collagen Hormone Endotrophin by VS-041, a Novel Drug Candidate for Heart Failure with Preserved Ejection Fraction von Plonowski, Artur, Berger, Joel, Pratt, Benjamin, Krupa, Magdalena, Vekich, John, Bochenek, Wieslaw, Larson, Christopher, Moreno, Ydalina, Genovese, Federica

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SRT-015, best-in-class apoptosis signal-regulating kinase 1 inhibitor, demonstrates preclinical efficacy in acute models of liver injury von Elias, Kathleen, Brown, S. David, Burge, Daniel, McDonnell, Neil D., Plonowski, Artur

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FRI-397 - SRT-015, best-in-class apoptosis signal-regulating kinase 1 inhibitor, demonstrates preclinical efficacy in acute models of liver injury von Elias, Kathleen, Brown, S. David, Burge, Daniel, McDonnell, Neil D., Plonowski, Artur

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Human Renal Cell Carcinoma Expresses Distinct Binding Sites for Growth Hormone-Releasing Hormone von Halmos, Gabor, Schally, Andrew V., Varga, Jozsef L., Plonowski, Artur, Rekasi, Zoltan, Czompoly, Tamas

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MetAP2 inhibition increases energy expenditure through direct action on brown adipocytes von Huang, Huey-Jing, Holub, Corine, Rolzin, Paul, Bilakovics, James, Fanjul, Andrea, Satomi, Yoshinori, Plonowski, Artur, Larson, Christopher J., Farrell, Pamela J.

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Using Target Engagement Biomarkers to Predict Clinical Efficacy of MetAP2 Inhibitors von Farrell, Pamela J, Zopf, Christopher J, Huang, Huey-Jing, Balakrishna, Deepika, Holub, Corine, Bilakovics, James, Fanjul, Andrea, Matuszkiewicz, Jennifer, Plonowski, Artur, Rolzin, Paul, Banerjee, Urmi, Ermolieff, Jacques, Cheruvallath, Zacharia S, McBride, Christopher, Bartkowski, Darian, Mazur, Crystal, Pachori, Alok, Larson, Christopher J

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Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRβ von Kick, Ellen, Martin, Richard, Xie, Yinong, Flatt, Brenton, Schweiger, Edwin, Wang, Tie-Lin, Busch, Brett, Nyman, Michael, Gu, Xiao-Hui, Yan, Grace, Wagner, Brandee, Nanao, Max, Nguyen, Lam, Stout, Thomas, Plonowski, Artur, Schulman, Ira, Ostrowski, Jacek, Kirchgessner, Todd, Wexler, Ruth, Mohan, Raju

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Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design—Part 1 von Cheruvallath, Zacharia, Tang, Mingnam, McBride, Christopher, Komandla, Mallareddy, Miura, Joanne, Ton-Nu, Thu, Erikson, Phil, Feng, Jun, Farrell, Pamela, Lawson, J. David, Vanderpool, Darin, Wu, Yiqin, Dougan, Douglas R., Plonowski, Artur, Holub, Corine, Larson, Chris

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Hypothalamic Hormones and Cancer von Schally, Andrew V., Comaru-Schally, Ana Maria, Nagy, Attila, Kovacs, Magdolna, Szepeshazi, Karoly, Plonowski, Artur, Varga, Jozsef L., Halmos, Gabor

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Time-dependent inhibition of PHD2 von Tcholakov, Isabelle, Grimshaw, Charles E, Shi, Lihong, Kiryanov, Andre, Murphy, Sean T, Larson, Christopher J, Plonowski, Artur, Ermolieff, Jacques

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Discovery of Highly Potent Liver X Receptor β Agonists von Kick, Ellen K, Busch, Brett B, Martin, Richard, Stevens, William C, Bollu, Venkataiah, Xie, Yinong, Boren, Brant C, Nyman, Michael C, Nanao, Max H, Nguyen, Lam, Plonowski, Artur, Schulman, Ira G, Yan, Grace, Zhang, Huiping, Hou, Xiaoping, Valente, Meriah N, Narayanan, Rangaraj, Behnia, Kamelia, Rodrigues, A. David, Brock, Barry, Smalley, James, Cantor, Glenn H, Lupisella, John, Sleph, Paul, Grimm, Denise, Ostrowski, Jacek, Wexler, Ruth R, Kirchgessner, Todd, Mohan, Raju

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