An exposure‐response analysis of ponesimod clinical efficacy in a randomized phase III study in patients with relapsing multiple sclerosis von Valenzuela, Belén, Olsson Gisleskog, Per, Poggesi, Italo, Sidorenko, Tatiana, Burcklen, Michel, Kracker, Hilke, Pérez‐Ruixo, Juan Jose

Volltext

Pharmacokinetic–pharmacodynamic modelling of neutrophil response to G‐CSF in healthy subjects and patients with chemotherapy‐induced neutropenia von Melhem, Murad, Delor, Isabelle, Pérez‐Ruixo, Juan Jose, Harrold, John, Chow, Andrew, Wu, Liviawati, Jacqmin, Philippe

Volltext

Mechanistic modeling projections of antibody persistence after homologous booster regimens of COVID‐19 vaccine Ad26.COV2.S in humans von Dari, Anna, Jacqmin, Philippe, Iwaki, Yuki, Neyens, Martine, Le Gars, Mathieu, Sadoff, Jerald, Hardt, Karin, Ruiz‐Guiñazú, Javier, Pérez‐Ruixo, Juan José

Volltext

Population Pharmacokinetic Analysis of Darunavir and Tenofovir Alafenamide in HIV-1-Infected Patients on the Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Single-Tablet... von Ackaert, Oliver, McDougall, David, Pérez-Ruixo, Carlos, Pérez-Ruixo, Juan Jose, Jezorwski, John, Crauwels, Herta M.

Volltext

Population Pharmacokinetics of Apalutamide and its Active Metabolite N-Desmethyl-Apalutamide in Healthy and Castration-Resistant Prostate Cancer Subjects von Pérez-Ruixo, Carlos, Pérez-Blanco, Jonás Samuel, Chien, Caly, Yu, Margaret, Ouellet, Daniele, Pérez-Ruixo, Juan-José, Ackaert, Oliver

Volltext

An Exposure-Response Analysis of the Clinical Efficacy of Ponesimod in a Randomized Phase II Study in Patients with Multiple Sclerosis von Gisleskog, Per Olsson, Valenzuela, Belén, Scherz, Tatiana, Burcklen, Michel, Pérez-Ruixo, Juan Jose, Poggesi, Italo

Volltext

Model‐based meta‐analysis to quantify the effects of short interfering RNA therapeutics on hepatitis B surface antigen turnover in hepatitis B‐infected mice von Sandra, Louis, T'jollyn, Huybrecht, Vermeulen, An, Ackaert, Oliver, Perez‐Ruixo, Juan‐Jose

Volltext

Modeling of delays in PKPD: classical approaches and a tutorial for delay differential equations von Koch, Gilbert, Krzyzanski, Wojciech, Pérez-Ruixo, Juan Jose, Schropp, Johannes

Volltext

Pharmacokinetic‐Pharmacodynamic Modeling of the Ponesimod Effect on Heart Rate in Patients With Multiple Sclerosis von Valenzuela, Belén, Poggesi, Italo, Luyckx, Nicolas, Vaclavkova, Andrea, Pérez‐Ruixo, Juan José

Volltext

Pharmacodynamic-Mediated Drug Disposition (PDMDD) Model of Daratumumab Monotherapy in Patients with Multiple Myeloma von Li, Xia, Dosne, Anne-Gaëlle, Pérez Ruixo, Carlos, Perez Ruixo, Juan Jose

Volltext

Mechanistic Model Describing the Time Course of Humoral Immunity Following Ad26.COV2.S Vaccination in Non-Human Primates von Dari, Anna, Solforosi, Laura, Roozendaal, Ramon, Hoetelmans, Richard M W, Pérez-Ruixo, Juan-José, Boulton, Muriel

Volltext

Denosumab Dose Selection for Patients with Bone Metastases from Solid Tumors von DOSHI, Sameer, SUTJANDRA, Liviawati, ZHENG, Jenny, SOHN, Winnie, PETERSON, Mark, JANG, Graham, CHOW, Andrew T, PEREZ-RUIXO, Juan Jose

Volltext

Effect of Ponesimod Exposure on Total Lymphocyte Dynamics in Patients with Multiple Sclerosis von Valenzuela, Belén, Pérez-Ruixo, Juan-José, Leirens, Quentin, Ouwerkerk-Mahadevan, Sivi, Poggesi, Italo

Volltext

Pharmacodynamics-Mediated Drug Disposition (PDMDD) and Precursor Pool Lifespan Model for Single Dose of Romiplostim in Healthy Subjects von Wang, Yow-Ming C., Krzyzanski, Wojciech, Doshi, Sameer, Xiao, Jim J., Pérez-Ruixo, Juan Jose, Chow, Andrew T.

Volltext

The Use of Pharmacometrics to Optimize Biosimilar Development von Dodds, Mike, Chow, Vincent, Markus, Richard, Pérez-Ruixo, Juan José, Shen, Danny, Gibbs, Megan

Volltext

Population Pharmacokinetics of Total and Free Erdafitinib in Adult Healthy Volunteers and Cancer Patients: Analysis of Phase 1 and Phase 2 Studies von Dosne, Anne‐Gaelle, Valade, Elodie, Stuyckens, Kim, Li, Lilian Y., Ouellet, Daniele, Perez‐Ruixo, Juan Jose

Volltext

Effect of grapefruit juice on the pharmacokinetics of docetaxel in cancer patients: a case report von Valenzuela, Belén, Rebollo, Joseba, Pérez, Tania, Brugarolas, Antonio, Pérez‐Ruixo, Juan José

Volltext

Efficacy and safety exposure–response relationships of apalutamide in patients with metastatic castration-sensitive prostate cancer: results from the phase 3 TITAN study von T’jollyn, Huybrecht, Ackaert, Oliver, Chien, Caly, Lopez-Gitlitz, Angela, McCarthy, Sharon, Ruixo, Carlos Perez, Karsh, Lawrence, Chi, Kim, Chowdhury, Simon, Ruixo, Juan-Jose Perez, Agarwal, Neeraj

Volltext

Nicotine Population Pharmacokinetics in Healthy Smokers After Intravenous, Oral, Buccal and Transdermal Administration von Olsson Gisleskog, Per O., Perez Ruixo, Juan José, Westin, Åke, Hansson, Anna C., Soons, Paul A.

Volltext

Pharmacodynamic Analysis of Recombinant Human Erythropoietin Effect on Reticulocyte Production Rate and Age Distribution in Healthy Subjects von Pérez-Ruixo, Juan José, Krzyzanski, Wojciech, Hing, Jeremy

Volltext