Recent applications of seven-membered rings in drug design von Ouvry, Gilles

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The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyr... von Pike, Kurt G, Barlaam, Bernard, Cadogan, Elaine, Campbell, Andrew, Chen, Yingxue, Colclough, Nicola, Davies, Nichola L, de-Almeida, Camila, Degorce, Sebastien L, Didelot, Myriam, Dishington, Allan, Ducray, Richard, Durant, Stephen T, Hassall, Lorraine A, Holmes, Jane, Hughes, Gareth D, MacFaul, Philip A, Mulholland, Keith R, McGuire, Thomas M, Ouvry, Gilles, Pass, Martin, Robb, Graeme, Stratton, Natalie, Wang, Zhenhua, Wilson, Joanne, Zhai, Baochang, Zhao, Kang, Al-Huniti, Nidal

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Discovery of Novel 3‑Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase von Degorce, Sébastien L, Barlaam, Bernard, Cadogan, Elaine, Dishington, Allan, Ducray, Richard, Glossop, Steven C, Hassall, Lorraine A, Lach, Franck, Lau, Alan, McGuire, Thomas M, Nowak, Thorsten, Ouvry, Gilles, Pike, Kurt G, Thomason, Andrew G

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Novel library synthesis of 3,4-disubstituted pyridin-2(1 H )-ones via cleavage of pyridine-2-oxy-7-azabenzotriazole ethers under ionic hydrogenation conditions at room temperature von Pierre, Romain, Brethon, Anne, Jacques, Sylvain A, Blond, Aurélie, Chambon, Sandrine, Talano, Sandrine, Raffin, Catherine, Musicki, Branislav, Bouix-Peter, Claire, Tomas, Loic, Ouvry, Gilles, Morgentin, Rémy, Hennequin, Laurent F, Harris, Craig S

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Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)‑4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3‑b]pyridazin-... von Bradbury, Robert H, Callis, Rowena, Carr, Gregory R, Chen, Huawei, Clark, Edwin, Feron, Lyman, Glossop, Steve, Graham, Mark A, Hattersley, Maureen, Jones, Chris, Lamont, Scott G, Ouvry, Gilles, Patel, Anil, Patel, Joe, Rabow, Alfred A, Roberts, Craig A, Stokes, Stephen, Stratton, Natalie, Walker, Graeme E, Ward, Lara, Whalley, David, Whittaker, David, Wrigley, Gail, Waring, Michael J

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Essential ingredients for rational drug design von Jarvis, Ashley, Ouvry, Gilles

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Substituted Allyl Diphenylphosphine Oxides as Radical Allylating Agents von Ouvry, Gilles, Quiclet-Sire, Béatrice, Zard, Samir Z.

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Intrinsic Property Forecast Index (iPFI) as a Rule of Thumb for Medicinal Chemists to Remove a Phototoxicity Liability von Fournier, Jean-François, Bouix-Peter, Claire, Duvert, Denis, Luzy, Anne-Pascale, Ouvry, Gilles

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The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyr... von Pike, Kurt G, Barlaam, Bernard, Cadogan, Elaine, Campbell, Andrew, Chen, Yingxue, Colclough, Nicola, Davies, Nichola L, de-Almeida, Camila, Degorce, Sebastien L, Didelot, Myriam, Dishington, Allan, Ducray, Richard, Durant, Stephen T, Hassall, Lorraine A, Holmes, Jane, Hughes, Gareth D, MacFaul, Philip A, Mulholland, Keith R, McGuire, Thomas M, Ouvry, Gilles, Pass, Martin, Robb, Graeme, Stratton, Natalie, Wang, Zhenhua, Wilson, Joanne, Zhai, Baochang, Zhao, Kang, Al-Huniti, Nidal

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Structure-based design of Trifarotene (CD5789), a potent and selective RARγ agonist for the treatment of acne von Thoreau, Etienne, Arlabosse, Jean-Marie, Bouix-Peter, Claire, Chambon, Sandrine, Chantalat, Laurent, Daver, Sébastien, Dumais, Laurence, Duvert, Gwenaëlle, Feret, Angélique, Ouvry, Gilles, Pascau, Jonathan, Raffin, Catherine, Rodeville, Nicolas, Soulet, Catherine, Tabet, Samuel, Talano, Sandrine, Portal, Thibaud

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Discovery of phenoxyindazoles and phenylthioindazoles as RORγ inverse agonists von Ouvry, Gilles, Bouix-Peter, Claire, Ciesielski, Fabrice, Chantalat, Laurent, Christin, Olivier, Comino, Catherine, Duvert, Denis, Feret, Christophe, Harris, Craig S., Lamy, Laurent, Luzy, Anne-Pascale, Musicki, Branislav, Orfila, Danielle, Pascau, Jonathan, Parnet, Véronique, Perrin, Agnès, Pierre, Romain, Polge, Gaëlle, Raffin, Catherine, Rival, Yves, Taquet, Nathalie, Thoreau, Etienne, Hennequin, Laurent F.

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Route scouting and optimization of a potent sulfoximine-based inverse agonist of RORγt von Lafitte, Guillaume, Parnet, Veronique, Pierre, Romain, Raffin, Catherine, Vatinel, Rodolphe, Musicki, Branislav, Tomas, Loic, Bouix-Peter, Claire, Ouvry, Gilles, Daver, Sebastien, Arlabosse, Jean-Marie, Boiteau, Jean-Guy, Gerfaud, Thibaud, Harris, Craig S.

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A facile and rapid preparation of hydroxamic acids by hydroxylaminolysis using DBU as base von Beillard, Audrey, Bhurruth-Alcor, Yushma, Bouix-Peter, Claire, Bouquet, Karinne, Chambon, Sandrine, Clary, Laurence, Harris, Craig S., Millois, Corinne, Mouis, Grégoire, Ouvry, Gilles, Pierre, Romain, Reitz, Arnaud, Tomas, Loic

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Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective... von Barlaam, Bernard, Cosulich, Sabina, Delouvrié, Bénédicte, Ellston, Rebecca, Fitzek, Martina, Germain, Hervé, Green, Stephen, Hancox, Urs, Harris, Craig S., Hudson, Kevin, Lambert-van der Brempt, Christine, Lebraud, Honorine, Magnien, Françoise, Lamorlette, Maryannick, Le Griffon, Antoine, Morgentin, Rémy, Ouvry, Gilles, Page, Ken, Pasquet, Georges, Polanska, Urszula, Ruston, Linette, Saleh, Twana, Vautier, Michel, Ward, Lara

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Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis von Boiteau, Jean-Guy, Ouvry, Gilles, Arlabosse, Jean-Marie, Astri, Stéphanie, Beillard, Audrey, Bhurruth-Alcor, Yushma, Bonnary, Laetitia, Bouix-Peter, Claire, Bouquet, Karine, Bourotte, Marilyne, Cardinaud, Isabelle, Comino, Catherine, Deprez, Benoît, Duvert, Denis, Féret, Angélique, Hacini-Rachinel, Feriel, Harris, Craig S., Luzy, Anne-Pascale, Mathieu, Arnaud, Millois, Corinne, Orsini, Nicolas, Pascau, Jonathan, Pinto, Artur, Piwnica, David, Polge, Gaëlle, Reitz, Arnaud, Reversé, Kevin, Rodeville, Nicolas, Rossio, Patricia, Spiesse, Delphine, Tabet, Samuel, Taquet, Nathalie, Tomas, Loïc, Vial, Emmanuel, Hennequin, Laurent F.

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Sulfoximines as potent RORγ inverse agonists von Ouvry, Gilles, Bihl, Franck, Bouix-Peter, Claire, Christin, Olivier, Defoin-Platel, Claire, Deret, Sophie, Feret, Christophe, Froude, David, Hacini-Rachinel, Feriel, Harris, Craig S., Hervouet, Catherine, Lafitte, Guillaume, Luzy, Anne-Pascale, Musicki, Branislav, Orfila, Danielle, Parnet, Veronique, Pascau, Coralie, Pascau, Jonathan, Pierre, Romain, Raffin, Catherine, Rossio, Patricia, Spiesse, Delphine, Taquet, Nathalie, Thoreau, Etienne, Vatinel, Rodolphe, Vial, Emmanuel, Hennequin, Laurent F.

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A convenient one-pot synthesis of boroxoles from diboronic acid von Lafitte, Guillaume, Kunihiro, Kana, Bonneaud, Céline, Dréan, Bénédicte, Gaigne, Frédéric, Parnet, Véronique, Pierre, Romain, Raffin, Catherine, Vatinel, Rodolphe, Fournier, Jean-François, Musicki, Branislav, Ouvry, Gilles, Bouix-Peter, Claire, Tomas, Loic, Harris, Craig S.

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Correction to Discovery of Novel 3‑Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase von Degorce, Sébastien L, Barlaam, Bernard, Cadogan, Elaine, Dishington, Allan, Ducray, Richard, Glossop, Steven C, Hassall, Lorraine A, Lach, Franck, Lau, Alan, McGuire, Thomas M, Nowak, Thorsten, Ouvry, Gilles, Pike, Kurt G, Thomason, Andrew G

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Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors von Barlaam, Bernard, Cosulich, Sabina, Fitzek, Martina, Germain, Hervé, Green, Stephen, Hanson, Lyndsey L., Harris, Craig S., Hancox, Urs, Hudson, Kevin, Lambert-van der Brempt, Christine, Lamorlette, Maryannick, Magnien, Françoise, Ouvry, Gilles, Page, Ken, Ruston, Linette, Ward, Lara, Delouvrié, Bénédicte

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Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold von Barlaam, Bernard, Cosulich, Sabina, Fitzek, Martina, Green, Stephen, Harris, Craig S., Hudson, Kevin, Lambert-van der Brempt, Christine, Ouvry, Gilles, Page, Ken, Ruston, Linette, Ward, Lara, Delouvrié, Bénédicte

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