Drug Discovery on Natural Products: From Ion Channels to nAChRs, from Nature to Libraries, from Analytics to Assays von Otvos, Reka A., Still, Kristina B.M., Somsen, Govert W., Smit, August B., Kool, Jeroen

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Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling von Slagboom, Julien, Otvos, Reka A., Cardoso, Fernanda C., Iyer, Janaki, Visser, Jeroen C., van Doodewaerd, Bjorn R., McCleary, Ryan J.R., Niessen, Wilfried M.A., Somsen, Govert W., Lewis, Richard J., Kini, R. Manjunatha, Smit, August B., Casewell, Nicholas R., Kool, Jeroen

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Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity von Pintér, Gábor, Bereczki, Ilona, Batta, Gyula, Ötvös, Réka, Sztaricskai, Ferenc, Rőth, Erzsébet, Ostorházi, Eszter, Rozgonyi, Ferenc, Naesens, Lieve, Szarvas, Mariann, Boda, Zoltán, Herczegh, Pál

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Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity von Pintér, Gábor, Bereczki, Ilona, Batta, Gyula, Otvös, Réka, Sztaricskai, Ferenc, Roth, Erzsébet, Ostorházi, Eszter, Rozgonyi, Ferenc, Naesens, Lieve, Szarvas, Mariann, Boda, Zoltán, Herczegh, Pál

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Development of an Online Cell-Based Bioactivity Screening Method by Coupling Liquid Chromatography to Flow Cytometry with Parallel Mass Spectrometry von Otvos, Reka A, van Nierop, Pim, Niessen, Wilfried M. A, Kini, R. Manjunatha, Somsen, Govert W, Smit, August B, Kool, Jeroen

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At-Line Cellular Screening Methodology for Bioactives in Mixtures Targeting the α7-Nicotinic Acetylcholine Receptor von Otvos, Reka A., Mladic, Marija, Arias-Alpizar, Gabriela, Niessen, Wilfried M.A., Somsen, Govert W., Smit, August B., Kool, Jeroen

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An efficient analytical platform for on-line microfluidic profiling of neuroactive snake venoms towards nicotinic receptor affinity von Heus, Ferry, Vonk, Freek, Otvos, Reka A., Bruyneel, Ben, Smit, August B., Lingeman, Henk, Richardson, Michael, Niessen, Wilfried M.A., Kool, Jeroen

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Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms von Otvos, Reka A, Iyer, Janaki Krishnamoorthy, van Elk, René, Ulens, Chris, Niessen, Wilfried M A, Somsen, Govert W, Kini, R Manjunatha, Smit, August B, Kool, Jeroen

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Analytical workflow for rapid screening and purification of bioactives from venom proteomes von Otvos, Reka A., Heus, Ferry, Vonk, Freek J., Halff, Jenny, Bruyneel, Ben, Paliukhovich, Iryna, Smit, August B., Niessen, Wilfried M.A., Kool, Jeroen

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Miniaturized bioaffinity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail von Heus, Ferry, Otvos, Reka A, Aspers, Ruud L E G, van Elk, Rene, Halff, Jenny I, Ehlers, Andreas W, Dutertre, Sébastien, Lewis, Richard J, Wijmenga, Sybren, Smit, August B, Niessen, Wilfried M A, Kool, Jeroen

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Microfluidic Chip–Based Online Screening Coupled to Mass Spectrometry von Iyer, Janaki Krishnamoorthy, Otvos, Reka A., Kool, Jeroen, Kini, R. Manjunatha

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Novel mechanism of modulation at a ligand-gated ion channel; action of 5-Cl-indole at the 5-HT 3 A receptor von Powell, Andrew D, Grafton, Gillian, Roberts, Alexander, Larkin, Shannon, O'Neill, Nathanael, Palandri, Josephine, Otvos, Reka, Cooper, Alison J, Ulens, Chris, Barnes, Nicholas M

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Novel mechanism of modulation at a ligand‐gated ion channel; action of 5‐Cl‐indole at the 5‐HT3A receptor von Powell, Andrew D, Grafton, Gillian, Roberts, Alexander, Larkin, Shannon, O'Neill, Nathanael, Palandri, Josephine, Otvos, Reka, Cooper, Alison J, Ulens, Chris, Barnes, Nicholas M

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Novel mechanism of modulation at a ligand-gated ion channel; action of 5-Cl-indole at the 5-HT(3)A receptor von Powell, Andrew D, Grafton, Gillian, Roberts, Alexander, Larkin, Shannon, O'Neill, Nathanael, Palandri, Josephine, Otvos, Reka, Cooper, Alison J, Ulens, Chris, Barnes, Nicholas M

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Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms von Otvos, Reka A, Iyer, Janaki Krishnamoorthy, van Elk, Rene, Ulens, Chris, Niessen, Wilfried M.A, Somsen, Govert W, Kini, R. Manjunatha, Smit, August B, Kool, Jeroen

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Novel mechanism of modulation at a ligand-gated ion channel; action of 5-Cl-indole at the 5-HT3 A receptor von Powell, Andrew D, Grafton, Gillian, Roberts, Alexander, Larkin, Shannon, O'Neill, Nathanael, Palandri, Josephine, Otvos, Reka, Cooper, Alison J, Ulens, Chris, Barnes, Nicholas M

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Investigations of the mechanism behind the rapid absorption of nano-amorphous abiraterone acetate von Basa-Dénes, Orsolya, Solymosi, Tamás, Ötvös, Zsolt, Angi, Réka, Ujhelyi, Andrea, Jordán, Tamás, Heltovics, Gábor, Glavinas, Hristos

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Solubility Measurements at 296 and 310 K and Physicochemical Characterization of Abiraterone and Abiraterone Acetate von Solymosi, Tamás, Tóth, Ferenc, Orosz, János, Basa-Dénes, Orsolya, Angi, Réka, Jordán, Tamás, Ötvös, Zsolt, Glavinas, Hristos

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Development of an abiraterone acetate formulation with improved oral bioavailability guided by absorption modeling based on in vitro dissolution and permeability measurements von Solymosi, Tamás, Ötvös, Zsolt, Angi, Réka, Ordasi, Betti, Jordán, Tamás, Semsey, Sándor, Molnár, László, Ránky, Soma, Filipcsei, Genovéva, Heltovics, Gábor, Glavinas, Hristos

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Novel formulation of abiraterone acetate might allow significant dose reduction and eliminates substantial positive food effect von Solymosi, Tamás, Ötvös, Zsolt, Angi, Réka, Ordasi, Betti, Jordán, Tamás, Molnár, László, McDermott, John, Zann, Vanessa, Church, Ann, Mair, Stuart, Filipcsei, Genovéva, Heltovics, Gábor, Glavinas, Hristos

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