Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism von Loregger, Anke, Raaben, Matthijs, Nieuwenhuis, Joppe, Tan, Josephine M. E., Jae, Lucas T., van den Hengel, Lisa G., Hendrix, Sebastian, van den Berg, Marlene, Scheij, Saskia, Song, Ji-Ying, Huijbers, Ivo J., Kroese, Lona J., Ottenhoff, Roelof, van Weeghel, Michel, van de Sluis, Bart, Brummelkamp, Thijn, Zelcer, Noam

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Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans von Hendrix, Sebastian, Kingma, Jenina, Ottenhoff, Roelof, Valiloo, Masoud, Svecla, Monika, Zijlstra, Lobke F., Sachdev, Vinay, Kovac, Kristina, Levels, Johannes H. M., Jongejan, Aldo, de Boer, Jan F., Kuipers, Folkert, Rimbert, Antoine, Norata, Giuseppe D., Loregger, Anke, Zelcer, Noam

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Elevated globotriaosylsphingosine is a hallmark of Fabry disease von Aerts, Johannes M, Groener, Johanna E, Kuiper, Sijmen, Donker-Koopman, Wilma E, Strijland, Anneke, Ottenhoff, Roelof, van Roomen, Cindy, Mirzaian, Mina, Wijburg, Frits A, Linthorst, Gabor E, Vedder, Anouk C, Rombach, Saskia M, Cox-Brinkman, Josanne, Somerharju, Pentti, Boot, Rolf G, Hollak, Carla E, Brady, Roscoe O, Poorthuis, Ben J

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Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases[S] von Marques, AndréR.A., Mirzaian, Mina, Akiyama, Hisako, Wisse, Patrick, Ferraz, Maria J., Gaspar, Paulo, Ghauharali-van der Vlugt, Karen, Meijer, Rianne, Giraldo, Pilar, Alfonso, Pilar, Irún, Pilar, Dahl, Maria, Karlsson, Stefan, Pavlova, Elena V., Cox, Timothy M., Scheij, Saskia, Verhoek, Marri, Ottenhoff, Roelof, van Roomen, CindyP.A.A., Pannu, Navraj S., van Eijk, Marco, Dekker, Nick, Boot, Rolf G., Overkleeft, Herman S., Blommaart, Edward, Hirabayashi, Yoshio, Aerts, Johannes M.

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Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages von van Wouw, Suzanne A.E., van den Berg, Marlene, El Ouraoui, Maroua, Meurs, Amber, Kingma, Jenina, Ottenhoff, Roelof, Loix, Melanie, Hoeksema, Marten A., Prange, Koen, Pasterkamp, Gerard, Hendriks, Jerome J.A., Bogie, Jeroen F.J., van Klinken, Jan B., Vaz, Frederic M., Jongejan, Aldo, de Winther, Menno P.J., Zelcer, Noam

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Pharmacological Inhibition of Glucosylceramide Synthase Enhances Insulin Sensitivity von AERTS, Johannes M, OTTENHOFF, Roelof, SETHI, Jaswinder K, O'RAHILLY, Stephen, OVERKLEEFT, Hermen S, POWLSON, Andrew S, GREFHORST, Aldo, VAN EIJK, Marco, DUBBELHUIS, Peter F, ATEN, Jan, KUIPERS, Folkert, SERLIE, Mireille J, WENNEKES, Tom

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Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene von Cook, Emma C L, Nelson, Jessica K, Sorrentino, Vincenzo, Koenis, Duco, Moeton, Martina, Scheij, Saskia, Ottenhoff, Roelof, Bleijlevens, Boris, Loregger, Anke, Zelcer, Noam

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Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival von Gabriel, Tanit L, Mirzaian, Mina, Hooibrink, Berend, Ottenhoff, Roelof, van Roomen, Cindy, Aerts, Johannes M F G, van Eijk, Marco

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Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice von Marques, André R A, Aten, Jan, Ottenhoff, Roelof, van Roomen, Cindy P A A, Herrera Moro, Daniela, Claessen, Nike, Vinueza Veloz, María Fernanda, Zhou, Kuikui, Lin, Zhanmin, Mirzaian, Mina, Boot, Rolf G, De Zeeuw, Chris I, Overkleeft, Herman S, Yildiz, Yildiz, Aerts, Johannes M F G

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Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease von Marques, André R A, Gabriel, Tanit L, Aten, Jan, van Roomen, Cindy P A A, Ottenhoff, Roelof, Claessen, Nike, Alfonso, Pilar, Irún, Pilar, Giraldo, Pilar, Aerts, Johannes M F G, van Eijk, Marco

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Impaired amino acid metabolism contributes to fasting-induced hypoglycemia in fatty acid oxidation defects von Houten, Sander M, Herrema, Hilde, Te Brinke, Heleen, Denis, Simone, Ruiter, Jos P N, van Dijk, Theo H, Argmann, Carmen A, Ottenhoff, Roelof, Müller, Michael, Groen, Albert K, Kuipers, Folkert, Reijngoud, Dirk-Jan, Wanders, Ronald J A

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Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions von Boer, Daphne E., Mirzaian, Mina, Ferraz, Maria J., Zwiers, Kimberley C., Baks, Merel V., Hazeu, Marc D., Ottenhoff, Roelof, Marques, André R.A., Meijer, Rianne, Roos, Jonathan C.P., Cox, Timothy M., Boot, Rolf G., Pannu, Navraj, Overkleeft, Herman S., Artola, Marta, Aerts, Johannes M.

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Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes von Herrera Moro Chao, Daniela, Kallemeijn, Wouter W, Marques, Andre R A, Orre, Marie, Ottenhoff, Roelof, van Roomen, Cindy, Foppen, Ewout, Renner, Maria C, Moeton, Martina, van Eijk, Marco, Boot, Rolf G, Kamphuis, Willem, Hol, Elly M, Aten, Jan, Overkleeft, Hermen S, Kalsbeek, Andries, Aerts, Johannes M F G

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Preclinical efficacy and safety of adeno-associated virus 5 alpha-galactosidase: A gene therapy for Fabry disease von Liefhebber, Jolanda M.P., Brasser, Giso, Spronck, Elisabeth A., Ottenhoff, Roelof, Paerels, Lieke, Ferraz, Maria J., Schwarz, Lukas K., Efthymiopoulou, Nikoleta, Kuo, Chi-Lin, Montenegro-Miranda, Paula S., Evers, Melvin M., Aerts, Johannes M.F.G., Liu, Ying Poi

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Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein von Vrins, Carlos L.J., Ottenhoff, Roelof, van den Oever, Karin, de Waart, Dirk R., Kruyt, J. Kar, Zhao, Ying, van Berkel, Theo J.C., Havekes, Louis M., Aerts, Johannes M., van Eck, Miranda, Rensen, Patrick C.N., Groen, Albert K.

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Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models von Kramer, Gertjan, Wegdam, Wouter, Donker‐Koopman, Wilma, Ottenhoff, Roelof, Gaspar, Paulo, Verhoek, Marri, Nelson, Jessica, Gabriel, Tanit, Kallemeijn, Wouter, Boot, Rolf G., Laman, Jon D., Vissers, Johannes P.C., Cox, Timothy, Pavlova, Elena, Moran, Mary Teresa, Aerts, Johannes M., Eijk, Marco

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Dual-Action Lipophilic Iminosugar Improves Glycemic Control in Obese Rodents by Reduction of Visceral Glycosphingolipids and Buffering of Carbohydrate Assimilation von Wennekes, Tom, Meijer, Alfred J, Groen, Albert K, Boot, Rolf G, Groener, Johanna E, van Eijk, Marco, Ottenhoff, Roelof, Bijl, Nora, Ghauharali, Karen, Song, Hang, O’Shea, Tom J, Liu, Hanlan, Yew, Nelson, Copeland, Diane, van den Berg, Richard J, van der Marel, Gijsbert A, Overkleeft, Herman S, Aerts, Johannes M

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Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice von Bijl, Nora, Sokolović, Milka, Vrins, Carlos, Langeveld, Mirjam, Moerland, Perry D., Ottenhoff, Roelof, van Roomen, Cindy P. A. A., Claessen, Nike, Boot, Rolf G., Aten, Jan, Groen, Albert K., Aerts, Johannes M. F. G., van Eijk, Marco

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Reducing Glycosphingolipid Content in Adipose Tissue of Obese Mice Restores Insulin Sensitivity, Adipogenesis and Reduces Inflammation von Eijk, Marco van, Aten, Jan, Bijl, Nora, Ottenhoff, Roelof, Roomen, Cindy P.A.A van, Dubbelhuis, Peter F, Seeman, Ingar, Ghauharali-van der Vlugt, Karen, Overkleeft, Hermen S, Arbeeny, Cynthia, Groen, Albert K, Aerts, Johannes M.F.G

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Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes von Kallemeijn, Wouter W, Scheij, Saskia, Hoogendoorn, Sascha, Witte, Martin D, Herrera Moro Chao, Daniela, van Roomen, Cindy P A A, Ottenhoff, Roelof, Overkleeft, Herman S, Boot, Rolf G, Aerts, Johannes M F G

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