Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity von Bryce, Dianne K., Ware, Chris M., Woodhouse, Janice D., Ciaccio, Paul J., Ellis, J. Michael, Hegde, Laxminarayan G., Kuruvilla, Sabu, Maddess, Matthew L., Markgraf, Carrie G., Otte, Karin M., Poulet, Frederique M., Timmins, Lauren M., Kennedy, Matthew E., Fell, Matthew J.

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Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors von Keylor, Mitchell H, Gulati, Anmol, Kattar, Solomon D, Johnson, Rebecca E, Chau, Ryan W, Margrey, Kaila A, Ardolino, Michael J, Zarate, Cayetana, Poremba, Kelsey E, Simov, Vladimir, Morriello, Gregori J, Acton, John J, Pio, Barbara, Yan, Xin, Palte, Rachel L, McMinn, Spencer E, Nogle, Lisa, Lesburg, Charles A, Adpressa, Donovon, Lin, Shishi, Neelamkavil, Santhosh, Liu, Ping, Su, Jing, Hegde, Laxminarayan G, Woodhouse, Janice D, Faltus, Robert, Xiong, Tina, Ciaccio, Paul J, Piesvaux, Jennifer, Otte, Karin M, Wood, Harold B, Kennedy, Matthew E, Bennett, David Jonathan, DiMauro, Erin F, Fell, Matthew J, Fuller, Peter H

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Discovery and Optimization of N‑Heteroaryl Indazole LRRK2 Inhibitors von Logan, Kaitlyn M., Kaplan, Will, Simov, Vladimir, Zhou, Hua, Li, Derun, Torres, Luis, Morriello, Gregori J., Acton, John J., Pio, Barbara, Chen, Yi-Heng, Keylor, Mitchell H., Johnson, Rebecca, Kattar, Solomon D., Chau, Ryan, Yan, Xin, Ardolino, Michael, Zarate, Cayetana, Otte, Karin M., Palte, Rachel L., Xiong, Tina, McMinn, Spencer E., Lin, Shishi, Neelamkavil, Santhosh F., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Woodhouse, Janice D., Moy, Lily Y., Ciaccio, Paul J., Piesvaux, Jennifer, Zebisch, Matthias, Henry, Clare, Barker, John, Wood, Harold B., Kennedy, Matthew E., DiMauro, Erin F., Fell, Matthew J., Fuller, Peter H.

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Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson’s Disease von Kattar, Solomon D., Gulati, Anmol, Margrey, Kaila A., Keylor, Mitchell H., Ardolino, Michael, Yan, Xin, Johnson, Rebecca, Palte, Rachel L., McMinn, Spencer E., Nogle, Lisa, Su, Jing, Xiao, Dong, Piesvaux, Jennifer, Lee, Susi, Hegde, Laxminarayan G., Woodhouse, Janice D., Faltus, Robert, Moy, Lily Y., Xiong, Tina, Ciaccio, Paul J., Pearson, Kara, Patel, Mayankbhai, Otte, Karin M., Leyns, Cheryl E.G., Kennedy, Matthew E., Bennett, David Jonathan, DiMauro, Erin F., Fell, Matthew J., Fuller, Peter H.

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Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing von Li, Derun, Sloman, David L, Achab, Abdelghani, Zhou, Hua, McGowan, Meredeth A, White, Catherine, Gibeau, Craig, Zhang, Hongjun, Pu, Qinglin, Bharathan, Indu, Hopkins, Brett, Liu, Kun, Ferguson, Heidi, Fradera, Xavier, Lesburg, Charles A, Martinot, Theodore A, Qi, Ji, Song, Zhiguo J, Yin, Jingjun, Zhang, Huangguang, Song, Licheng, Wan, Baoqiang, DAddio, Suzanne, Solban, Nicolas, Miller, J Richard, Zamlynny, Beata, Bass, Alan, Freeland, Elizabeth, Ykoruk, Bridget, Hilliard, Catherine, Ferraro, Jude, Zhai, Jin, Knemeyer, Ian, Otte, Karin M, Vincent, Stella, Sciammetta, Nunzio, Pasternak, Alexander, Bennett, David Jonathan, Han, Yongxin

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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1‑Heteroaryl‑1H‑Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease von Candito, David A., Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W., Lapointe, Blair T., Methot, Joey L., DeMong, Duane E., Graham, Thomas H., Kurukulasuriya, Ravi, Keylor, Mitchell H., Tong, Ling, Morriello, Gregori J., Acton, John J., Pio, Barbara, Liu, Weiguo, Scott, Jack D., Ardolino, Michael J., Martinot, Theodore A., Maddess, Matthew L., Yan, Xin, Gunaydin, Hakan, Palte, Rachel L., McMinn, Spencer E., Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C., Lesburg, Charles A., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Moy, Lily Y., Woodhouse, Janice D., Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A., Otte, Karin M., Kennedy, Matthew E., Bennett, David Jonathan, DiMauro, Erin F., Fell, Matthew J., Neelamkavil, Santhosh, Wood, Harold B., Fuller, Peter H., Ellis, J. Michael

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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease von Candito, David A, Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W, Lapointe, Blair T, Methot, Joey L, DeMong, Duane E, Graham, Thomas H, Kurukulasuriya, Ravi, Keylor, Mitchell H, Tong, Ling, Morriello, Gregori J, Acton, John J, Pio, Barbara, Liu, Weiguo, Scott, Jack D, Ardolino, Michael J, Martinot, Theodore A, Maddess, Matthew L, Yan, Xin, Gunaydin, Hakan, Palte, Rachel L, McMinn, Spencer E, Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C, Lesburg, Charles A, Liu, Ping, Su, Jing, Hegde, Laxminarayan G, Moy, Lily Y, Woodhouse, Janice D, Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A, Otte, Karin M, Kennedy, Matthew E, Bennett, David Jonathan, DiMauro, Erin F, Fell, Matthew J, Neelamkavil, Santhosh, Wood, Harold B, Fuller, Peter H, Ellis, J Michael

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Discovery and mechanistic study of Al(III)-catalyzed transamidation of tertiary amides von Hoerter, Justin M, Otte, Karin M, Gellman, Samuel H, Cui, Qiang, Stahl, Shannon S

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Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors von Methot, Joey L, Achab, Abdelghani, Christopher, Matthew, Zhou, Hua, McGowan, Meredeth A, Trotter, B. Wesley, Fradera, Xavier, Lesburg, Charles A, Goldenblatt, Peter, Hill, Armetta, Chen, Dapeng, Otte, Karin M, Augustin, Martin, Shah, Sanjiv, Katz, Jason D

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Carbamate and N‑Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors von Li, Derun, Deng, Yongqi, Achab, Abdelghani, Bharathan, Indu, Hopkins, Brett Andrew, Yu, Wensheng, Zhang, Hongjun, Sanyal, Sulagna, Pu, Qinglin, Zhou, Hua, Liu, Kun, Lim, Jongwon, Fradera, Xavier, Lesburg, Charles A, Lammens, Alfred, Martinot, Theodore A, Cohen, Ryan D, Doty, Amy C, Ferguson, Heidi, Nickbarg, Elliott B, Cheng, Mangeng, Spacciapoli, Peter, Geda, Prasanthi, Song, Xuelei, Smotrov, Nadya, Abeywickrema, Pravien, Andrews, Christine, Chamberlin, Chad, Mabrouk, Omar, Curran, Patrick, Richards, Matthew, Saradjian, Peter, Miller, J. Richard, Knemeyer, Ian, Otte, Karin M, Vincent, Stella, Sciammetta, Nunzio, Pasternak, Alexander, Bennett, David Jonathan, Han, Yongxin

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Discovery and Mechanistic Study of AlIII-Catalyzed Transamidation of Tertiary Amides von Hoerter, Justin M, Otte, Karin M, Gellman, Samuel H, Cui, Qiang, Stahl, Shannon S

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Mechanism of Al(III)-catalyzed transamidation of unactivated secondary carboxamides von Hoerter, Justin M, Otte, Karin M, Gellman, Samuel H, Stahl, Shannon S

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Mechanism of AlIII-Catalyzed Transamidation of Unactivated Secondary Carboxamides von Hoerter, Justin M, Otte, Karin M, Gellman, Samuel H, Stahl, Shannon S

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Purine derivatives as potent γ-secretase modulators von Rivkin, Alexey, Ahearn, Sean P., Chichetti, Stephanie M., Hamblett, Christopher L., Garcia, Yudith, Martinez, Michelle, Hubbs, Jed L., Reutershan, Michael H., Daniels, Matthew H., Siliphaivanh, Phieng, Otte, Karin M., Li, Chaomin, Rosenau, Andrew, Surdi, Laura M., Jung, Joon, Hughes, Bethany L., Crispino, Jamie L., Nikov, George N., Middleton, Richard E., Moxham, Christopher M., Szewczak, Alexander A., Shah, Sanjiv, Moy, Lily Y., Kenific, Candia M., Tanga, Flobert, Cruz, Jonathan C., Andrade, Paula, Angagaw, Minilik H., Shomer, Nirah H., Miller, Thomas, Munoz, Benito, Shearman, Mark S.

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Effects of Side Chain Configuration and Backbone Spacing on the Gene Delivery Properties of Lysine-Derived Cationic Polymers von Eldred, Sarah E, Pancost, Margaret R, Otte, Karin M, Rozema, David, Stahl, Shannon S, Gellman, Samuel H

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Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1) von Wilson, Kevin J, Witter, David J, Grimm, Jonathan B, Siliphaivanh, Phieng, Otte, Karin M, Kral, Astrid M, Fleming, Judith C, Harsch, Andreas, Hamill, Julie E, Cruz, Jonathan C, Chenard, Melissa, Szewczak, Alexander A, Middleton, Richard E, Hughes, Bethany L, Dahlberg, William K, Secrist, J Paul, Miller, Thomas A

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Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1) von WILSON, Kevin J, WITTER, David J, CHENARD, Melissa, SZEWCZAK, Alexander A, MIDDLETON, Richard E, HUGHES, Bethany L, DAHLBERG, William K, SECRIST, J. Paul, MILLER, Thomas A, GRIMM, Jonathan B, SILIPHAIVANH, Phieng, OTTE, Karin M, KRAL, Astrid M, FLEMING, Judith C, HARSCH, Andreas, HAMILL, Julie E, CRUZ, Jonathan C

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Discovery and Mechanistic Study of Al III -Catalyzed Transamidation of Tertiary Amides von Hoerter, Justin M., Otte, Karin M., Gellman, Samuel H., Cui, Qiang, Stahl, Shannon S.

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Mechanism of Al III -Catalyzed Transamidation of Unactivated Secondary Carboxamides von Hoerter, Justin M., Otte, Karin M., Gellman, Samuel H., Stahl, Shannon S.

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Purine derivatives as potent g-secretase modulators von Rivkin, Alexey, Ahearn, Sean P, Chichetti, Stephanie M, Hamblett, Christopher L, Garcia, Yudith, Martinez, Michelle, Hubbs, Jed L, Reutershan, Michael H, Daniels, Matthew H, Siliphaivanh, Phieng, Otte, Karin M, Li, Chaomin, Rosenau, Andrew, Surdi, Laura M, Jung, Joon, Hughes, Bethany L, Crispino, Jamie L, Nikov, George N, Middleton, Richard E, Moxham, Christopher M, Szewczak, Alexander A, Shah, Sanjiv, Moy, Lily Y, Kenific, Candia M, Tanga, Flobert, Cruz, Jonathan C, Andrade, Paula, Angagaw, Minilik H, Shomer, Nirah H, Miller, Thomas, Munoz, Benito, Shearman, Mark S

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