Chronic pain and medullary descending facilitation von Porreca, Frank, Ossipov, Michael H, Gebhart, G.F

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Nature's first “atypical opioids”: Kratom and mitragynines von Raffa, R. B., Pergolizzi, J. V., Taylor, R., Ossipov, M. H.

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Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors von Dogrul, Ahmet, Ossipov, Michael H, Porreca, Frank

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Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization von Vera-Portocarrero, L.P., Zhang, E.-T., Ossipov, M.H., Xie, J.Y., King, T., Lai, J., Porreca, F.

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Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat von Kovelowski, C.J., Ossipov, M.H., Sun, H., Lai, J., Malan, T.P., Porreca, F.

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Tonic Descending Facilitation from the Rostral Ventromedial Medulla Mediates Opioid-Induced Abnormal Pain and Antinociceptive Tolerance von Vanderah, Todd W, Suenaga, Nova M. H, Ossipov, Michael H, Malan, T. Philip, Jr, Lai, Josephine, Porreca, Frank

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Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain von Wang, R, Guo, W, Ossipov, M.H, Vanderah, T.W, Porreca, F, Lai, J

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Enhanced Evoked Excitatory Transmitter Release in Experimental Neuropathy Requires Descending Facilitation von Gardell, L. R, Vanderah, T. W, Gardell, S. E, Wang, R, Ossipov, M. H, Lai, J, Porreca, F

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Indirect‐acting strategy of opioid action instead of direct receptor activation: dual‐acting enkephalinase inhibitors (DENKIs) von Raffa, R. B., Pergolizzi, J. V., Taylor, R., Ossipov, M. H.

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Dynorphin Promotes Abnormal Pain and Spinal Opioid Antinociceptive Tolerance von Vanderah, Todd W, Gardell, Luis R, Burgess, Shannon E, Ibrahim, Mohab, Dogrul, Ahmet, Zhong, Cheng-Min, Zhang, En-Tan, Malan, T. Philip, Jr, Ossipov, Michael H, Lai, Josephine, Porreca, Frank

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Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections von Sun, H, Ren, K, Zhong, C.M, Ossipov, M.H, Malan, T.P, Lai, J, Porreca, F

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Spinal and Supraspinal Mechanisms of Neuropathic Pain von OSSIPOV, MICHAEL H., LAI, JOSEPHINE, MALAN JR, T. PHILIP, PORRECA, FRANK

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A Comparison of the Potential Role of the Tetrodotoxin-Insensitive Sodium Channels, PN3/SNS and NaN/SNS2, in Rat Models of Chronic Pain von Porreca, Frank, Lai, Josephine, Bian, Di, Wegert, Sandra, Ossipov, Michael H., Eglen, Richard M., Kassotakis, Laura, Novakovic, Sanja, Rabert, Douglas K., Sangameswaran, Lakshmi, Hunter, John C.

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Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats von Malan, T.Philip, Ossipov, Michael H, Gardell, Luis R, Ibrahim, Mohab, Bian, Di, Lai, Josephine, Porreca, Frank

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Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats von Ossipov, Michael H., Bian, Di, Malan, T.Philip, Lai, Josephine, Porreca, Frank

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Time-Dependent Descending Facilitation from the Rostral Ventromedial Medulla Maintains, But Does Not Initiate, Neuropathic Pain von Burgess, Shannon E, Gardell, Luis R, Ossipov, Michael H, Malan, T. Philip, Jr, Vanderah, Todd W, Lai, Josephine, Porreca, Frank

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Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin von Vanderah, Todd W., Ossipov, Michael H., Lai, Josephine, Malan, T.Philip, Porreca, Frank

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Sustained Morphine Exposure Induces a Spinal Dynorphin-Dependent Enhancement of Excitatory Transmitter Release from Primary Afferent Fibers von Gardell, Luis R, Wang, Ruizhong, Burgess, Shannon E, Ossipov, Michael H, Vanderah, Todd W, Malan, T. Philip, Jr, Lai, Josephine, Porreca, Frank

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Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain von Gardell, L.R, Ibrahim, M, Wang, R, Wang, Z, Ossipov, M.H, Malan, T.P, Porreca, F, Lai, J

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Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure von Ossipov, Michael H., Lai, Josephine, King, Tamara, Vanderah, Todd W., Porreca, Frank

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