New Peptide-Based Pharmacophore Activates 20S Proteasome von Osmulski, Paweł A, Karpowicz, Przemysław, Jankowska, Elżbieta, Bohmann, Jonathan, Pickering, Andrew M, Gaczyńska, Maria

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Interplay between Structure and Charge as a Key to Allosteric Modulation of Human 20S Proteasome by the Basic Fragment of HIV-1 Tat Protein von Karpowicz, Przemysław, Osmulski, Paweł A, Witkowska, Julia, Sikorska, Emilia, Giżyńska, Małgorzata, Belczyk-Ciesielska, Agnieszka, Gaczynska, Maria E, Jankowska, Elżbieta

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Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy von Hussong, Stacy A., Banh, Andy Q., Van Skike, Candice E., Dorigatti, Angela O., Hernandez, Stephen F., Hart, Matthew J., Ferran, Beatriz, Makhlouf, Haneen, Gaczynska, Maria, Osmulski, Pawel A., McAllen, Salome A., Dineley, Kelly T., Ungvari, Zoltan, Perez, Viviana I., Kayed, Rakez, Galvan, Veronica

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Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer's disease von Edrey, Yael H, Medina, David X, Gaczynska, Maria, Osmulski, Pawel A, Oddo, Salvatore, Caccamo, Antonella, Buffenstein, Rochelle

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The central unit within the 19S regulatory particle of the proteasome von Gaczynska, Maria, Glickman, Michael H, Rosenzweig, Rina, Osmulski, Pawel A

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Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination von Chou, Chih-Wei, Hung, Chia-Nung, Chiu, Cheryl Hsiang-Ling, Tan, Xi, Chen, Meizhen, Chen, Chien-Chin, Saeed, Moawiz, Hsu, Che-Wei, Liss, Michael A., Wang, Chiou-Miin, Lai, Zhao, Alvarez, Nathaniel, Osmulski, Pawel A., Gaczynska, Maria E., Lin, Li-Ling, Ortega, Veronica, Kirma, Nameer B., Xu, Kexin, Liu, Zhijie, Kumar, Addanki P., Taverna, Josephine A., Velagaleti, Gopalrao V. N., Chen, Chun-Liang, Zhang, Zhao, Huang, Tim Hui-Ming

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AXL-initiated paracrine activation of pSTAT3 enhances mesenchymal and vasculogenic supportive features of tumor-associated macrophages von Hung, Chia-Nung, Chen, Meizhen, DeArmond, Daniel T., Chiu, Cheryl H.-L., Limboy, Catherine A., Tan, Xi, Kusi, Meena, Chou, Chih-Wei, Lin, Li-Ling, Zhang, Zhao, Wang, Chiou-Miin, Chen, Chun-Liang, Mitsuya, Kohzoh, Osmulski, Pawel A., Gaczynska, Maria E., Kirma, Nameer B., Vadlamudi, Ratna K., Gibbons, Don L., Warner, Steve, Brenner, Andrew J., Mahadevan, Daruka, Michalek, Joel E., Huang, Tim H.-M., Taverna, Josephine A.

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A Role for the Proteasome Alpha2 Subunit N-Tail in Substrate Processing von Sahu, Indrajit, Bajorek, Monika, Tan, Xiaolin, Srividya, Madabhushi, Krutauz, Daria, Reis, Noa, Osmulski, Pawel A, Gaczynska, Maria E, Glickman, Michael H

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Electronic Circular Dichroism Detects Conformational Changes Associated with Proteasome Gating Confirmed Using AFM Imaging von D'Urso, Alessandro, Purrello, Roberto, Cunsolo, Alessandra, Milardi, Danilo, Fattorusso, Caterina, Persico, Marco, Gaczynska, Maria, Osmulski, Pawel A, Santoro, Anna Maria

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AFM Imaging Reveals Topographic Diversity of Wild Type and Z Variant Polymers of Human α1-Proteinase Inhibitor von Gaczynska, Maria, Karpowicz, Przemyslaw, Stuart, Christine E, Norton, Malgorzata G, Teckman, Jeffrey H, Marszal, Ewa, Osmulski, Pawel A

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The Growth-Suppressive Function of the Polycomb Group Protein Polyhomeotic Is Mediated by Polymerization of Its Sterile Alpha Motif (SAM) Domain von Robinson, Angela K., Leal, Belinda Z., Chadwell, Linda V., Wang, Renjing, Ilangovan, Udayar, Kaur, Yogeet, Junco, Sarah E., Schirf, Virgil, Osmulski, Pawel A., Gaczynska, Maria, Hinck, Andrew P., Demeler, Borries, McEwen, Donald G., Kim, Chongwoo A.

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Small Molecule Modulation of Proteasome Assembly von Njomen, Evert, Osmulski, Pawel A, Jones, Corey L, Gaczynska, Maria, Tepe, Jetze J

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Rapamycin allosterically inhibits the proteasome von Osmulski, Pawel A, Gaczynska, Maria

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Harnessing proteasome dynamics and allostery in drug design von Gaczynska, Maria, Osmulski, Pawel A

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Contacts with Macrophages Promote an Aggressive Nanomechanical Phenotype of Circulating Tumor Cells in Prostate Cancer von Osmulski, Pawel A, Cunsolo, Alessandra, Chen, Meizhen, Qian, Yusheng, Lin, Chun-Lin, Hung, Chia-Nung, Mahalingam, Devalingam, Kirma, Nameer B, Chen, Chun-Liang, Taverna, Josephine A, Liss, Michael A, Thompson, Ian M, Huang, Tim H-M, Gaczynska, Maria E

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A Tetrahedral Transition State at the Active Sites of the 20S Proteasome Is Coupled to Opening of the α-Ring Channel von Osmulski, Pawel A., Hochstrasser, Mark, Gaczynska, Maria

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Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer von Taverna, Josephine A, Hung, Chia-Nung, DeArmond, Daniel T, Chen, Meizhen, Lin, Chun-Lin, Osmulski, Pawel A, Gaczynska, Maria E, Wang, Chiou-Miin, Lucio, Nicholas D, Chou, Chih-Wei, Chen, Chun-Liang, Nazarullah, Alia, Lampkin, Shellye R, Qiu, Lianqun, Bearss, David J, Warner, Steven, Whatcott, Clifford J, Mouritsen, Lars, Wade, Mark, Weitman, Steven, Mesa, Ruben A, Kirma, Nameer B, Chao, Wei-Ting, Huang, Tim H-M

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A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition von Rodriguez, Karl A., Osmulski, Pawel A., Pierce, Anson, Weintraub, Susan T., Gaczynska, Maria, Buffenstein, Rochelle

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Ex vivo drug testing of patient-derived lung organoids to predict treatment responses for personalized medicine von Taverna, Josephine A., Hung, Chia-Nung, Williams, Madison, Williams, Ryan, Chen, Meizhen, Kamali, Samaneh, Sambandam, Vaishnavi, Hsiang-Ling Chiu, Cheryl, Osmulski, Pawel A., Gaczynska, Maria E., DeArmond, Daniel T., Gaspard, Christine, Mancini, Maria, Kusi, Meena, Pandya, Abhishek N., Song, Lina, Jin, Lingtao, Schiavini, Paolo, Chen, Chun-Liang

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Nanoenzymology of the 20S Proteasome:  Proteasomal Actions Are Controlled by the Allosteric Transition von Osmulski, Pawel A, Gaczynska, Maria

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