HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration von Mielcarek, Michal, Landles, Christian, Weiss, Andreas, Bradaia, Amyaouch, Seredenina, Tamara, Inuabasi, Linda, Osborne, Georgina F, Wadel, Kristian, Touller, Chrystelle, Butler, Rachel, Robertson, Janette, Franklin, Sophie A, Smith, Donna L, Park, Larry, Marks, Paul A, Wanker, Erich E, Olson, Eric N, Luthi-Carter, Ruth, van der Putten, Herman, Beaumont, Vahri, Bates, Gillian P

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Dysfunction of the CNS-heart axis in mouse models of Huntington's disease von Mielcarek, Michal, Inuabasi, Linda, Bondulich, Marie K, Muller, Thomas, Osborne, Georgina F, Franklin, Sophie A, Smith, Donna L, Neueder, Andreas, Rosinski, Jim, Rattray, Ivan, Protti, Andrea, Bates, Gillian P

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Meso scale discovery-based assays for the detection of aggregated huntingtin von Reindl, Wolfgang, Baldo, Barbara, Schulz, Jana, Janack, Isabell, Lindner, Ilka, Kleinschmidt, Markus, Sedaghat, Yalda, Thiede, Christina, Tillack, Karsten, Schmidt, Christina, Cardaun, Isabell, Schwagarus, Tom, Herrmann, Frank, Hotze, Madlen, Osborne, Georgina F, Herrmann, Simone, Weiss, Andreas, Zerbinatti, Celina, Bates, Gillian P, Bard, Jonathan, Munoz-Sanjuan, Ignacio, Macdonald, Douglas

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Alternative processing of human HTT mRNA with implications for Huntington's disease therapeutics von Fienko, Sandra, Landles, Christian, Sathasivam, Kirupa, McAteer, Sean J, Milton, Rebecca E, Osborne, Georgina F, Smith, Edward J, Jones, Samuel T, Bondulich, Marie K, Danby, Emily C E, Phillips, Jemima, Taxy, Bridget A, Kordasiewicz, Holly B, Bates, Gillian P

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A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease von Aldous, Sarah G, Smith, Edward J, Landles, Christian, Osborne, Georgina F, Cañibano-Pico, Maria, Nita, Iulia M, Phillips, Jemima, Zhang, Yongwei, Jin, Bo, Hirst, Marissa B, Benn, Caroline L, Bond, Brian C, Edelmann, Winfried, Greene, Jonathan R, Bates, Gillian P

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Phenotype onset in Huntington’s disease knock‐in mice is correlated with the incomplete splicing of the mutant huntingtin gene von Franich, Nicholas R., Hickey, Miriam A., Zhu, Chunni, Osborne, Georgina F., Ali, Nadira, Chu, Tiffany, Bove, Nicholas H., Lemesre, Vincent, Lerner, Renata P., Zeitlin, Scott O., Howland, David, Neueder, Andreas, Landles, Christian, Bates, Gillian P., Chesselet, Marie‐Francoise

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HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo von Mielcarek, Michal, Seredenina, Tamara, Stokes, Matthew P, Osborne, Georgina F, Landles, Christian, Inuabasi, Linda, Franklin, Sophie A, Silva, Jeffrey C, Luthi-Carter, Ruth, Beaumont, Vahri, Bates, Gillian P

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Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease von Menalled, Liliana B, Kudwa, Andrea E, Oakeshott, Steve, Farrar, Andrew, Paterson, Neil, Filippov, Igor, Miller, Sam, Kwan, Mei, Olsen, Michael, Beltran, Jose, Torello, Justin, Fitzpatrick, Jon, Mushlin, Richard, Cox, Kimberly, McConnell, Kristi, Mazzella, Matthew, He, Dansha, Osborne, Georgina F, Al-Nackkash, Rand, Bates, Gill P, Tuunanen, Pasi, Lehtimaki, Kimmo, Brunner, Dani, Ghavami, Afshin, Ramboz, Sylvie, Park, Larry, Macdonald, Douglas, Munoz-Sanjuan, Ignacio, Howland, David

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Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington’s disease mice von Bondulich, Marie K., Jolinon, Nelly, Osborne, Georgina F., Smith, Edward J., Rattray, Ivan, Neueder, Andreas, Sathasivam, Kirupa, Ahmed, Mhoriam, Ali, Nadira, Benjamin, Agnesska C., Chang, Xiaoli, Dick, James R. T., Ellis, Matthew, Franklin, Sophie A., Goodwin, Daniel, Inuabasi, Linda, Lazell, Hayley, Lehar, Adam, Richard-Londt, Angela, Rosinski, Jim, Smith, Donna L., Wood, Tobias, Tabrizi, Sarah J., Brandner, Sebastian, Greensmith, Linda, Howland, David, Munoz-Sanjuan, Ignacio, Lee, Se-Jin, Bates, Gillian P.

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Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches von Smith, Edward J, Sathasivam, Kirupa, Landles, Christian, Osborne, Georgina F, Mason, Michael A, Gomez-Paredes, Casandra, Taxy, Bridget A, Milton, Rebecca E, Ast, Anne, Schindler, Franziska, Zhang, Chuangchuang, Duan, Wenzhen, Wanker, Erich E, Bates, Gillian P

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Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington’S Disease Model von Landles, Christian, Milton, Rebecca E, Ali, Nadira, Flomen, Rachel, Flower, Michael, Schindler, Franziska, Gomez-Paredes, Casandra, Bondulich, Marie K, Osborne, Georgina F, Goodwin, Daniel, Salsbury, Grace, Benn, Caroline L, Sathasivam, Kirupa, Smith, Edward J, Tabrizi, Sarah J, Wanker, Erich E, Bates, Gillian P

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Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platforms von Landles, Christian, Milton, Rebecca E, Jean, Alexandre, McLarnon, Stuart, McAteer, Sean J, Taxy, Bridget A, Osborne, Georgina F, Zhang, Chuangchuang, Duan, Wenzhen, Howland, David, Bates, Gillian P

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Reducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD mice von Corrochano, Silvia, Renna, Maurizio, Osborne, Georgina, Carter, Sarah, Stewart, Michelle, May, Joel, Bates, Gillian P, Brown, Steve D M, Rubinsztein, David C, Acevedo-Arozena, Abraham

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UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome von Hjerpe, Roland, Bett, John S., Keuss, Matthew J., Solovyova, Alexandra, McWilliams, Thomas G., Johnson, Clare, Sahu, Indrajit, Varghese, Joby, Wood, Nicola, Wightman, Melanie, Osborne, Georgina, Bates, Gillian P., Glickman, Michael H., Trost, Matthias, Knebel, Axel, Marchesi, Francesco, Kurz, Thimo

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Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington disease models von Sogorb-Gonzalez, Marina, Landles, Christian, Caron, Nicholas S, Stam, Anouk, Osborne, Georgina, Hayden, Michael R, Howland, David, van Deventer, Sander, Bates, Gillian P, Vallès, Astrid, Evers, Melvin

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Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington's disease models von Sogorb-Gonzalez, Marina, Landles, Christian, Caron, Nicholas S, Stam, Anouk, Osborne, Georgina, Hayden, Michael R, Howland, David, van Deventer, Sander, Bates, Gillian P, Vallès, Astrid, Evers, Melvin

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Intracavitary ‘T4 immunotherapy’ of malignant mesothelioma using pan-ErbB re-targeted CAR T-cells von Klampatsa, Astero, Achkova, Daniela Y, Davies, David M, Parente-Pereira, Ana C, Woodman, Natalie, Rosekilly, James, Osborne, Georgina, Thayaparan, Thivyan, Bille, Andrea, Sheaf, Michael, Spicer, James F, King, Juliet, Maher, John

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Mutant HTT protein decreases with CAG repeat expansion: implications for therapeutics and bioassays von Landles, Christian, Osborne, Georgina F, Phillips, Jemima, Canibano-Pico, Maria, Nita, Iulia M, Ali, Nadira, Bobkov, Konstantin, Greene, Jonathan R, Sathasivam, Kirupa, Bates, Gillian P

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B3 Comparison of the effect of a pure CAG repeat and mixed cagcaa repeat on the extent to which the htt gene is aberrantly spliced in knock-in mice von Ali, Nadira S, Osborne, Georgina F, Benjamin, Agnesska C, Sathasivam, Kirupa, Neueder, Andreas, Howland, David, Bates, Gillian P

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Comprehensive geriatric assessment (CGA) in men age 70 or over with localized prostate cancer von Osborne, Georgina E.C., Gilbert, Duncan Charles, Robinson, Angus, Nikapota, Ashok, McKinna, Fiona, Villanueva, Michelle, Ring, Alistair E.

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