The road to Insurmountability: Novel avenues to better target CC Chemokine Receptors von Ortiz Zacarías, N.V.

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Development of the first potential nonpeptidic positron emission tomography tracer for the imaging of CCR2 receptors von Wagner, S., Moura Gatti, F., Silva, D.G. de, Ortiz Zacarias, N.V., Zweemer, A.J.M., Hermann, S., Koch, M., Weiss, C., Schepmann, D., Heitman, L.H., Tschammer, N., Kopka, K., Junker, A.

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Synthesis and biological evaluation of chemokine receptor ligands with 2-benzazepine scaffold von Thum, S., Kokornaczyk, A.K., Seki, T., De Maria, M., Ortiz Zacarias, N.V., Vries, H. de, Weiss, C., Koch, M.l., Schepmann, D., Kitamura, M., Tschammer, N., Heitman, L.H., Junker, A., Wuensch, B.

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A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy von Bot, I., Ortiz Zacarias, N.V., Witte, W.E. de, Vries, H. de, Santbrink, P.J. van, Velden, D. van der, Kroener, M.J., Berg, D.J. van den, Stamos, D., Lange, E.C.M. de, Kuiper, J., IJzerman, A.P., Heitman, L.H.

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A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy von Bot, I., Ortiz, Zacarias N.V., Witte, W.E.A. de, Vries, H. de, Santbrink, P.J. van, Velden, D. van der, Kröner, M.J., Berg, D.J. van der, Stamos, D., Lange, E.C.M. de, Kuiper, J., IJzerman, A.P., Heitman, L.H.

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Inhibition of macrophage migration in zebrafish larvae demonstrates in vivo efficacy of human CCR2 inhibitors von Sommer, F., Ortiz Zacarıas, N.V., Heitman, L.H., Meijer, A.H.

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Inhibition of macrophage migration in zebrafish larvae demonstrates in vivo efficacy of human CCR2 inhibitors von Sommer, F., Ortiz Zacarías, N.V., Heitman, L.H., Meijer, A.H.

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Anticancer opportunities at every stage of chemokine function von Ortiz Zacarías, N.V., Bemelmans, M.P., Handel, T.M., Visser, K.E. de, Heitman, L.H.

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Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists von Patberg, M., Isaak, A., Füsser, F., Ortiz Zacarías, N.V., Vinnenberg, L., Schulte, J., Michetti, L., Grey, L., Horst, C. van der, Hundehege, P., Koch, O., Heitman, L.H., Budde, T., Junker, A.

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Design and characterization of an intracellular covalent ligand for CC chemokine receptor 2 von Ortiz Zacarías, N.V., Chahal, K.K., Šimková, T., Horst, C. van der, Zheng, Y., Inoue, A., Theunissen, E., Mallee, L., Es, D. van der, Louvel, J., IJzerman, A.P., Handel, T.M., Kufareva, I., Heitman, L.H.

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Intracellular Receptor Modulation: Novel Approach to Target GPCRs von Ortiz Zacarías, N.V., Lenselink, E.B., IJzerman, A.P., Handel, T.M., Heitman, L.H.

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Synthesis and Pharmacological Evaluation of Triazolopyrimidinone Derivatives as Noncompetitive, Intracellular Antagonists for CC Chemokine Receptors 2 and 5 von Ortiz Zacarías, N.V., Veldhoven, J.P.D. van, Hollander, L.S. den, Dogan, B., Openy, J., Hsiao, Y.Y., Lenselink, E.B., Heitman, L.H., IJzerman, A.P.

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