SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel von Qiu, Zhaozhu, Dubin, Adrienne E, Mathur, Jayanti, Tu, Buu, Reddy, Kritika, Miraglia, Loren J, Reinhardt, Jürgen, Orth, Anthony P, Patapoutian, Ardem

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Co-regulatory networks of human serum proteins link genetics to disease von Emilsson, Valur, Ilkov, Marjan, Lamb, John R, Finkel, Nancy, Gudmundsson, Elias F, Pitts, Rebecca, Hoover, Heather, Gudmundsdottir, Valborg, Horman, Shane R, Aspelund, Thor, Shu, Le, Trifonov, Vladimir, Sigurdsson, Sigurdur, Manolescu, Andrei, Zhu, Jun, Olafsson, Örn, Jakobsdottir, Johanna, Lesley, Scott A, To, Jeremy, Zhang, Jia, Harris, Tamara B, Launer, Lenore J, Zhang, Bin, Eiriksdottir, Gudny, Yang, Xia, Orth, Anthony P, Jennings, Lori L, Gudnason, Vilmundur

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Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets von Horman, Shane R., Janas, Maja M., Litterst, Claudia, Wang, Bingbing, MacRae, Ian J., Sever, Mary J., Morrissey, David V., Graves, Paul, Luo, Biao, Umesalma, Shaikamjad, Qi, Hank H., Miraglia, Loren J., Novina, Carl D., Orth, Anthony P.

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Proteomic associations with forced expiratory volume: a Mendelian randomisation study von Axelsson, Gisli Thor, Jonmundsson, Thorarinn, Woo, Youngjae, Frick, Elisabet Alexandra, Aspelund, Thor, Loureiro, Joseph J, Orth, Anthony P, Jennings, Lori L, Gudmundsson, Gunnar, Emilsson, Valur, Gudmundsdottir, Valborg, Gudnason, Vilmundur

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Functional profiling of microtumors to identify cancer associated fibroblast-derived drug targets von Horman, Shane R, To, Jeremy, Lamb, John, Zoll, Jocelyn H, Leonetti, Nicole, Tu, Buu, Moran, Rita, Newlin, Robbin, Walker, John R, Orth, Anthony P

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Tumor suppressor protein (p)53, is a regulator of NF-κB repression by the glucocorticoid receptor von Murphy, Samantha H, Suzuki, Kotaro, Downes, Michael, Welch, Genevieve L, De Jesus, Paul, Miraglia, Loren J, Orth, Anthony P, Chanda, Sumit K, Evans, Ronald M, Verma, Inder M

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Large-Scale Analysis of the Human and Mouse Transcriptomes von Su, Andrew I., Cooke, Michael P., Ching, Keith A., Hakak, Yaron, Walker, John R., Wiltshire, Tim, Orth, Anthony P., Vega, Raquel G., Sapinoso, Lisa M., Moqrich, Aziz, Patapoutian, Ardem, Hampton, Garret M., Schultz, Peter G., Hogenesch, John B.

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High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor von Groot-Kormelink, Paul J, Ferrand, Sandrine, Kelley, Nicholas, Bill, Anke, Freuler, Felix, Imbert, Pierre-Eloi, Marelli, Anthony, Gerwin, Nicole, Sivilotti, Lucia G, Miraglia, Loren, Orth, Anthony P, Oakeley, Edward J, Schopfer, Ulrich, Siehler, Sandra

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FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells von Kim, Sungeun, Dubrovska, Anna, Salamone, Richard J, Walker, John R, Grandinetti, Kathryn B, Bonamy, Ghislain M C, Orth, Anthony P, Elliott, Jimmy, Porta, Diana Graus, Garcia-Echeverria, Carlos, Reddy, Venkateshwar A

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Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening von Zhou, Zongxiang, Patel, Manishha, Ng, Nicholas, Hsieh, Mindy H, Orth, Anthony P, Walker, John R, Batalov, Serge, Harris, Jennifer L, Liu, Jun

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An HTS-Compatible 3D Colony Formation Assay to Identify Tumor-Specific Chemotherapeutics von Horman, Shane R., To, Jeremy, Orth, Anthony P.

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GPR68 Senses Flow and Is Essential for Vascular Physiology von Xu, Jie, Mathur, Jayanti, Vessières, Emilie, Hammack, Scott, Nonomura, Keiko, Favre, Julie, Grimaud, Linda, Petrus, Matt, Francisco, Allain, Li, Jingyuan, Lee, Van, Xiang, Fu-li, Mainquist, James K., Cahalan, Stuart M., Orth, Anthony P., Walker, John R., Ma, Shang, Lukacs, Viktor, Bordone, Laura, Bandell, Michael, Laffitte, Bryan, Xu, Yan, Chien, Shu, Henrion, Daniel, Patapoutian, Ardem

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Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen von Hu, Xiaoyi V., Rodrigues, Tânia M. A., Tao, Haiyan, Baker, Robert K., Miraglia, Loren, Orth, Anthony P., Lyons, Gary E., Schultz, Peter G., Wu, Xu

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Screening the Mammalian Extracellular Proteome for Regulators of Embryonic Human Stem Cell Pluripotency von Gonzalez, Rodolfo, Jennings, Lori L., Knuth, Mark, Orth, Anthony P., Klock, Heath E., Ou, Weija, Feuerhelm, Julie, Hull, Mitchell V., Koesema, Eric, Wang, Yuping, Zhang, Jia, Wu, Chunlei, Cho, Charles Y., Su, Andrew I., Batalov, Serge, Chen, Hong, Johnson, Kristen, Laffitte, Bryan, Nguyerf, Deborah G., Snyder, Evan Y., Schult, Peter G., Harris, Jennifer L., Lesley, Scott A.

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Identification of a Family of cAMP Response Element-Binding Protein Coactivators by Genome-Scale Functional Analysis in Mammalian Cells von Iourgenko, Vadim, Zhang, Wenjun, Mickanin, Craig, Daly, Ira, Jiang, Can, Hexham, Jonathan M., Orth, Anthony P., Miraglia, Loren, Meltzer, Jodi, Garza, Dan, Chirn, Gung-Wei, McWhinnie, Elizabeth, Cohen, Dalia, Skelton, Joanne, Terry, Robert, Yu, Yang, Bodian, Dale, Buxton, Frank P., Zhu, Jian, Song, Chuanzheng, Labow, Mark A.

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A functional genomics approach to the mode of action of apratoxin A von Luesch, Hendrik, Chanda, Sumit K, Raya, R Marina, DeJesus, Paul D, Orth, Anthony P, Walker, John R, Izpisúa Belmonte, Juan Carlos, Schultz, Peter G

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coactivator trap identifies NONO (p54nrb) as a component of the cAMP-signaling pathway von Amelio, Antonio L, Miraglia, Loren J, Conkright, Juliana J, Mercer, Becky A, Batalov, Serge, Cavett, Valerie, Orth, Anthony P, Busby, Jennifer, Hogenesch, John B, Conkright, Michael D

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Genome-Wide Functional Analysis of Human Cell-Cycle Regulators von Mukherji, Mridul, Bell, Russell, Supekova, Lubica, Wang, Yan, Orth, Anthony P., Batalov, Serge, Miraglia, Loren, Huesken, Dieter, Lange, Joerg, Martin, Christopher, Sahasrabudhe, Sudhir, Reinhardt, Mischa, Natt, Francois, Hall, Jonathan, Mickanin, Craig, Labow, Mark, Chanda, Sumit K., Cho, Charles Y., Schultz, Peter G.

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Structure-guided combination therapy to potently improve the function of mutant CFTRs von Veit, Guido, Xu, Haijin, Dreano, Elise, Avramescu, Radu G., Bagdany, Miklos, Beitel, Lenore K., Roldan, Ariel, Hancock, Mark A., Lay, Cecilia, Li, Wei, Morin, Katelin, Gao, Sandra, Mak, Puiying A., Ainscow, Edward, Orth, Anthony P., McNamara, Peter, Edelman, Aleksander, Frenkiel, Saul, Matouk, Elias, Sermet-Gaudelus, Isabelle, Barnes, William G., Lukacs, Gergely L.

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Cofactors Required for TLR7- and TLR9-Dependent Innate Immune Responses von Chiang, Chih-yuan, Engel, Alex, Opaluch, Amanda M., Ramos, Irene, Maestre, Ana M., Secundino, Ismael, De Jesus, Paul D., Nguyen, Quy T., Welch, Genevieve, Bonamy, Ghislain M.C., Miraglia, Loren J., Orth, Anthony P., Nizet, Victor, Fernandez-Sesma, Ana, Zhou, Yingyao, Barton, Gregory M., Chanda, Sumit K.

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