Preclinical predictors that the orthosteric mGlu2/3 receptor antagonist LY3020371 will not engender ketamine-associated neurotoxic, motor, cognitive, subjective, or abuse-liability... von Witkin, J M, Monn, J A, Li, J, Johnson, B, McKinzie, D L, Wang, X-S, Heinz, B A, Li, R, Ornstein, P L, Smith, S C, Mitch, C H, Calligaro, D O, Swanson, S, Allen, D, Phillips, K, Gilmour, G

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LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors von Kingston, A.E, Ornstein, P.L, Wright, R.A, Johnson, B.G, Mayne, N.G, Burnett, J.P, Belagaje, R, Wu, S, Schoepp, D.D

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A Critical Role of a Facilitatory Presynaptic Kainate Receptor in Mossy Fiber LTP von Lauri, Sari E, Bortolotto, Zuner A, Bleakman, David, Ornstein, Paul L, Lodge, David, Isaac, John T.R, Collingridge, Graham L

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A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission von Bleakman, David, Clarke, Vernon R. J, Ballyk, Barbara A, Hoo, Ken H, Mandelzys, Allan, Pellizzari, Andrew, Bath, Catherine P, Thomas, Justyn, Sharpe, Erica F, Davies, Ceri H, Ornstein, Paul L, Schoepp, Darryle D, Kamboj, Rajender K, Collingridge, Graham L, Lodge, David

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LY293558, a Novel AMPA/GluR5 Antagonist, is Efficacious and Well-Tolerated in Acute Migraine von Sang, CN, Ramadan, NM, Wallihan, RG, Chappell, AS, Freitag, FG, Smith, TR, Silberstein, SD, Johnson, KW, Phebus, LA, Bleakman, D, Ornstein, PL, Arnold, B, Tepper, SJ, Vandenhende, F

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Comparative Effects of LY3020371, a Potent and Selective Metabotropic Glutamate (mGlu) 2/3 Receptor Antagonist, and Ketamine, a Noncompetitive N -Methyl-d-Aspartate Receptor Antago... von Witkin, J M, Mitchell, S N, Wafford, K A, Carter, G, Gilmour, G, Li, J, Eastwood, B J, Overshiner, C, Li, X, Rorick-Kehn, L, Rasmussen, K, Anderson, W H, Nikolayev, A, Tolstikov, V V, Kuo, M-S, Catlow, J T, Li, R, Smith, S C, Mitch, C H, Ornstein, P L, Swanson, S, Monn, J A

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Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat von Simmons, Rosa Maria A., Li, Dominic L., Hoo, Ken H., Deverill, Michelle, Ornstein, Paul L., Iyengar, Smriti

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The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity von Fitzjohn, S.M, Bortolotto, Z.A, Palmer, M.J, Doherty, A.J, Ornstein, P.L, Schoepp, D.D, Kingston, A.E, Lodge, D, Collingridge, G.L

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Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro von Miu, P, Jarvie, K.R, Radhakrishnan, V, Gates, M.R, Ogden, A, Ornstein, P.L, Zarrinmayeh, H, Ho, K, Peters, D, Grabell, J, Gupta, A, Zimmerman, D.M, Bleakman, D

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The GluR5 subtype of kainate receptor regulates excitatory synaptic transmission in areas CA1 and CA3 of the rat hippocampus von Vignes, M, Clarke, V.R.J, Parry, M.J, Bleakman, D, Lodge, D, Ornstein, P.L, Collingridge, G.L

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Synthesis and Evaluation of a Series of Novel 2-[(4-Chlorophenoxy)methyl]- benzimidazoles as Selective Neuropeptide Y Y1 Receptor Antagonists von Zarrinmayeh, Hamideh, Nunes, Anne M, Ornstein, Paul L, Zimmerman, Dennis M, Arnold, M. Brian, Schober, Douglas A, Gackenheimer, Susan L, Bruns, Robert F, Hipskind, Philip A, Britton, Thomas C, Cantrell, Buddy E, Gehlert, Donald R

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A novel, competitive mGlu5 receptor antagonist (LY344545) blocks DHPG‐induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices von Doherty, A J, Palmer, M J, Bortolotto, Z A, Hargreaves, A, Kingston, A E, Ornstein, P L, Schoepp, D D, Lodge, D, Collingridge, G L

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Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic Acid (AMPA) Receptors von Ornstein, Paul L, Zimmerman, Dennis M, Arnold, M. Brian, Bleisch, Thomas J, Cantrell, Buddy, Simon, Richard, Zarrinmayeh, Hamideh, Baker, S. Richard, Gates, Mary, Tizzano, Joseph P, Bleakman, David, Mandelzys, Allan, Jarvie, Kieth R, Ho, Ken, Deverill, Michelle, Kamboj, Rajender K

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Kainate receptors are involved in synaptic plasticity von Collingridge, Graham L, Bortolotto, Zuner A, Clarke, Vernon R. J, Delany, Caroline M, Parry, Michael C, Smolders, Ilse, Vignes, Michel, Ho, Ken H, Miu, Peter, Brinton, Bradford T, Fantaske, Robert, Ogden, Ann, Gates, Mary, Ornstein, Paul L, Lodge, David, Bleakman, David

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Structure-activity relationship of a series of diaminoalkyl substituted benzimidazole as neuropeptide Y Y1 receptor antagonists von Zarrinmayeh, Hamideh, Zimmerman, Dennis M., Cantrell, Buddy E., Schober, Douglas A., Bruns, Robert E., Gackenheimer, Susan L., Ornstein, Paul L., Hipskind, Philip A., Britton, Thomas C., Gehlert, Donald R.

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Pharmacological characterization of a GluR6 kainate receptor in cultured hippocampal neurons von Bleakman, David, Ogden, Ann-Marie, Ornstein, Paul L, Hoo, Ken

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2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 2. Effects of Aromatic S... von Ornstein, Paul L, Bleisch, Thomas J, Arnold, M. Brian, Kennedy, Joseph H, Wright, Rebecca A, Johnson, Bryan G, Tizzano, Joseph P, Helton, David R, Kallman, Mary Jeanne, Schoepp, Darryle D, Hérin, Marc

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2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 1. Effects of Alkyl, Ary... von Ornstein, Paul L, Bleisch, Thomas J, Arnold, M. Brian, Wright, Rebecca A, Johnson, Bryan G, Schoepp, Darryle D

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LY377770, a novel iGlu5 kainate receptor antagonist with neuroprotective effects in global and focal cerebral ischaemia von O'Neill, Michael J, Bogaert, Liesbeth, Hicks, Caroline A, Bond, Ann, Ward, Mark A, Ebinger, Guy, Ornstein, Paul L, Michotte, Yvette, Lodge, David

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Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate rec... von Wright, R A, Arnold, M B, Wheeler, W J, Ornstein, P L, Schoepp, D D

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