Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an op... von Geoerger, Birgit, Kang, Hyoung Jin, Yalon-Oren, Michal, Marshall, Lynley V, Vezina, Catherine, Pappo, Alberto, Laetsch, Theodore W, Petrilli, Antonio S, Ebinger, Martin, Toporski, Jacek, Glade-Bender, Julia, Nicholls, Wayne, Fox, Elizabeth, DuBois, Steven G, Macy, Margaret E, Cohn, Susan L, Pathiraja, Kumudu, Diede, Scott J, Ebbinghaus, Scot, Pinto, Navin

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Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency von Das, Anirban, Sudhaman, Sumedha, Morgenstern, Daniel, Coblentz, Ailish, Chung, Jiil, Stone, Simone C., Alsafwani, Noor, Liu, Zhihui Amy, Karsaneh, Ola Abu Al, Soleimani, Shirin, Ladany, Hagay, Chen, David, Zatzman, Matthew, Cabric, Vanja, Nobre, Liana, Bianchi, Vanessa, Edwards, Melissa, Sambira Nahum, Lauren C, Ercan, Ayse B., Nabbi, Arash, Constantini, Shlomi, Dvir, Rina, Yalon-Oren, Michal, Campino, Gadi Abebe, Caspi, Shani, Larouche, Valerie, Reddy, Alyssa, Osborn, Michael, Mason, Gary, Lindhorst, Scott, Bronsema, Annika, Magimairajan, Vanan, Opocher, Enrico, De Mola, Rebecca Loret, Sabel, Magnus, Frojd, Charlotta, Sumerauer, David, Samuel, David, Cole, Kristina, Chiaravalli, Stefano, Massimino, Maura, Tomboc, Patrick, Ziegler, David S., George, Ben, Van Damme, An, Hijiya, Nobuko, Gass, David, McGee, Rose B., Mordechai, Oz, Bowers, Daniel C., Laetsch, Theodore W., Lossos, Alexander, Blumenthal, Deborah T., Sarosiek, Tomasz, Yen, Lee Yi, Knipstein, Jeffrey, Bendel, Anne, Hoffman, Lindsey M., Luna-Fineman, Sandra, Zimmermann, Stefanie, Scheers, Isabelle, Nichols, Kim E., Zapotocky, Michal, Hansford, Jordan R., Maris, John M., Dirks, Peter, Taylor, Michael D., Kulkarni, Abhaya V., Shroff, Manohar, Tsang, Derek S., Villani, Anita, Xu, Wei, Aronson, Melyssa, Durno, Carol, Shlien, Adam, Malkin, David, Getz, Gad, Maruvka, Yosef E., Ohashi, Pamela S., Hawkins, Cynthia, Pugh, Trevor J., Bouffet, Eric, Tabori, Uri

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The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial von Kilburn, Lindsay B., Khuong-Quang, Dong-Anh, Hansford, Jordan R., Landi, Daniel, van der Lugt, Jasper, Leary, Sarah E. S., Driever, Pablo Hernáiz, Bailey, Simon, Perreault, Sébastien, McCowage, Geoffrey, Waanders, Angela J., Ziegler, David S., Witt, Olaf, Baxter, Patricia A., Kang, Hyoung Jin, Hassall, Timothy E., Han, Jung Woo, Hargrave, Darren, Franson, Andrea T., Yalon Oren, Michal, Toledano, Helen, Larouche, Valérie, Kline, Cassie, Abdelbaki, Mohamed S., Jabado, Nada, Gottardo, Nicholas G., Gerber, Nicolas U., Whipple, Nicholas S., Segal, Devorah, Chi, Susan N., Oren, Liat, Tan, Enrica E. K., Mueller, Sabine, Cornelio, Izzy, McLeod, Lisa, Zhao, Xin, Walter, Ashley, Da Costa, Daniel, Manley, Peter, Blackman, Samuel C., Packer, Roger J., Nysom, Karsten

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DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells von Chung, Jiil, Maruvka, Yosef E., Sudhaman, Sumedha, Kelly, Jacalyn, Haradhvala, Nicholas J., Bianchi, Vanessa, Edwards, Melissa, Forster, Victoria J., Nunes, Nuno M., Galati, Melissa A., Komosa, Martin, Deshmukh, Shriya, Cabric, Vanja, Davidson, Scott, Zatzman, Matthew, Light, Nicholas, Hayes, Reid, Brunga, Ledia, Anderson, Nathaniel D., Ho, Ben, Hodel, Karl P., Siddaway, Robert, Morrissy, A. Sorana, Bowers, Daniel C., Larouche, Valerie, Bronsema, Annika, Osborn, Michael, Cole, Kristina A., Opocher, Enrico, Mason, Gary, Thomas, Gregory A., Ben George, Ziegler, David S., Lindhorst, Scott, Vanan, Magimairajan, Yalon-Oren, Michal, Reddy, Alyssa T., Massimino, Maura, Tomboc, Patrick, Van Damme, An, Lossos, Alexander, Durno, Carol, Aronson, Melyssa, Morgenstern, Daniel A., Bouffet, Eric, Huang, Annie, Taylor, Michael D., Villani, Anita, Malkin, David, Hawkins, Cynthia E., Pursell, Zachary F., Shlien, Adam, Kunkel, Thomas A., Getz, Gad, Tabori, Uri

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The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial von Kilburn, Lindsay B, Khuong-Quang, Dong-Anh, Hansford, Jordan R, Landi, Daniel, van der Lugt, Jasper, Leary, Sarah E S, Driever, Pablo Hernáiz, Bailey, Simon, Perreault, Sébastien, McCowage, Geoffrey, Waanders, Angela J, Ziegler, David S, Witt, Olaf, Baxter, Patricia A, Kang, Hyoung Jin, Hassall, Timothy E, Han, Jung Woo, Hargrave, Darren, Franson, Andrea T, Yalon Oren, Michal, Toledano, Helen, Larouche, Valérie, Kline, Cassie, Abdelbaki, Mohamed S, Jabado, Nada, Gottardo, Nicholas G, Gerber, Nicolas U, Whipple, Nicholas S, Segal, Devorah, Chi, Susan N

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Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial von Kilburn, Lindsay B., Khuong-Quang, Dong-Anh, Hansford, Jordan R., Landi, Daniel, van der Lugt, Jasper, Leary, Sarah E. S., Driever, Pablo Hernáiz, Bailey, Simon, Perreault, Sébastien, McCowage, Geoffrey, Waanders, Angela J., Ziegler, David S., Witt, Olaf, Baxter, Patricia A., Kang, Hyoung Jin, Hassall, Timothy E., Han, Jung Woo, Hargrave, Darren, Franson, Andrea T., Yalon Oren, Michal, Toledano, Helen, Larouche, Valérie, Kline, Cassie, Abdelbaki, Mohamed S., Jabado, Nada, Gottardo, Nicholas G., Gerber, Nicolas U., Whipple, Nicholas S., Segal, Devorah, Chi, Susan N., Oren, Liat, Tan, Enrica E. K., Mueller, Sabine, Cornelio, Izzy, McLeod, Lisa, Zhao, Xin, Walter, Ashley, Da Costa, Daniel, Manley, Peter, Blackman, Samuel C., Packer, Roger J., Nysom, Karsten

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CTNI-24. CLINICAL ACTIVITY AND SAFETY OF THE RAF INHIBITOR TOVORAFENIB IN PATIENTS WITH OPTIC PATHWAY GLIOMAS IN THE REGISTRATIONAL PEDIATRIC LOW-GRADE GLIOMA ARM OF THE PHASE 2 FI... von Nysom, Karsten, Kilburn, Lindsay, Leary, Sarah, Landi, Daniel, de Vos-Kerkhof, E, Perreault, Sébastien, Witt, Olaf, Ziegler, David, Driever, Pablo Hernáiz, Franson, Andrea, Baxter, Patricia, Whipple, Nicholas S, Kline, Cassie, Segal, Devorah, Jabado, Nada, Bailey, Simon, McCowage, Geoffrey, Hansford, Jordan, Khuong-Quang, Dong-Anh, Gottardo, Nicholas, Hassall, Timothy, Han, Jung Woo, Oren, Michal Yalon, Chi, Susan, Lee, Vai, McLeod, Lisa, Qiu, Jiaheng, Walter, Ashley, Manley, Peter, Hargrave, Darren

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FIREFLY-1: A phase 2 study of the pan-RAF inhibitor DAY101 in pediatric patients with low-grade glioma von Kilburn, Lindsay Baker, Jabado, Nada, Franson, Andrea, Chi, Susan N., Fisher, Michael J., Hargrave, Darren R., Hansford, Jordan R., Ziegler, David S., Landi, Daniel, Kang, Hyoung Jin, Gerber, Nicolas U., Yalon-Oren, Michal, Cornelio, Izzy, Blackman, Samuel C., Cox, Michael Craig, Witt, Olaf, Prados, Michael, Mueller, Sabine

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CTNI-84. PNOC022: A COMBINATION THERAPY TRIAL USING AN ADAPTIVE PLATFORM DESIGN FOR PATIENTS WITH DIFFUSE MIDLINE GLIOMAS (DMGS) AT INITIAL DIAGNOSIS, POST-RADIATION THERAPY AND AT... von Kline, Cassie, Franson, Andrea, Banerjee, Anu, Reddy, Alyssa T, Raber, Shannon, Hoffman, Carly, Minturn, Jane, van der Lugt, Jasper, de Vos-Kerkhof, E, van Vuurden, Dannis, Gerber, Nicolas, Stuecklin, Ana Guerreiro, Kilburn, Lindsay, Elster, Jennifer, Whipple, Nicholas, Cohen, Kenneth, Oren, Michal Yalon, Gardner, Sharon, Cluster, Andrew, Chi, Susan, Landi, Daniel, McCowage, Geoffrey, Resnick, Adam, Phillips, Joanna, Bhatia, Aashim, Vossough, Arastoo, George, Elizabeth, Nabavizadeh, Ali, Braunstein, Steve, Gupta, Nalin, Prados, Michael, Waszak, Sebastian, Boyle-Lang, Janel, Molinaro, Annette, Dun, Matthew, Koschmann, Carl, Nazarian, Javad, Mueller, Sabine

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CTNI-68. FIREFLY-1 (PNOC026): PHASE 2 STUDY OF PAN-RAF INHIBITOR TOVORAFENIB IN PEDIATRIC AND YOUNG ADULT PATIENTS WITH RAF-ALTERED RECURRENT OR PROGRESSIVE LOW-GRADE GLIOMA OR ADV... von Kilburn, Lindsay, Landi, Daniel, Leary, Sarah, Ziegler, David, Baxter, Patricia, Franson, Andrea, McCowage, Geoffrey, Waanders, Angela, Van der Lugt, Jasper, Oren, Michal Yalon, Gerber, Nicolas, Gottardo, Nicholas, Khuong-Quang, Dong-Anh, Nysom, Karsten, Bailey, Simon, Driever, Pablo Hernáiz, Perreault, Sebastien, Witt, Olaf, Hahn, Seungmin, Hargrave, Darren, Hassall, Timothy, Jabado, Nada, Kang, Hyoung Jin, Larouche, Valerie, Toledano, Helen, Kline, Cassie, Abdelbaki, Mohamed, Chi, Susan, Gardner, Sharon, Whipple, Nicholas, Mueller, Sabine, Blackman, Samuel, Zhao, Xin, Da Costa, Daniel, Cox, Michael, Packer, Roger, Hansford, Jordan

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KEYNOTE-051: An update on the phase 2 results of pembrolizumab (pembro) in pediatric patients (pts) with advanced melanoma or a PD-L1–positive advanced, relapsed or refractory soli... von Geoerger, Birgit, Kang, Hyoung Jin, Yalon-Oren, Michal, Marshall, Lynley V., Vezina, Catherine, Pappo, Alberto S., Laetsch, Theodore Willis, Petrilli, Antonio Sergio, Ebinger, Martin, Toporski, Jacek, Glade-Bender, Julia, Nicholls, Wayne, Fox, Elizabeth, DuBois, Steven G., Macy, Margaret, Cohn, Susan Lerner, Pathiraja, Kumudu, Diede, Scott J., Ebbinghaus, Scot, Pinto, Navin R.

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ETMR-22. TITLE: DEFINING THE CLINICAL AND PROGNOSTIC LANDSCAPE OF EMBRYONAL TUMORS WITH MULTI-LAYERED ROSETTES (ETMRs), A RARE BRAIN TUMOR REGISTRY (RBTC) STUDY von Khan, Sara, Solano-Paez, Palma, Suwal, Tannu, Al-Karmi, Salma, Lu, Mei, Ho, Ben, Fouladi, Maryam, Leary, Sarah, Levy, Jean M Mulcahy, Lassaletta, Alvaro, Rivas, Eloy, Reddy, Alyssa, Gillespie, G Yancey, Gupta, Nalin, Yalon-Oren, Michal, Amariglio, Laura, Nakamura, Hideo, Wu, Kuo-Sheng, Wong, Tai-Tong, Ra, Young-Shin, Spina, Milena La, Emanuele, Policlinico Vittorio, Massimi, Luca, Buccoliero, Anna Maria, Hansford, Jordan R, Grundy, Richard G, Adamek, Dariusz, Fangusaro, Jason, Scharnhorst, David, Johnston, Donna, Lafay-Cousin, Lucie, Camelo-Piragua, Sandra, Kabbara, Nabil, Gajjar, Amar, Boutarbouch, Mahjouba, da Costa, Maria Joao Gil, Hanson, Derek, Wood, Paul, Al-Hussaini, Maysa, Amayiri, Nisreen, Wang, Yin, Catchpoole, Daniel, Michaud, Jean, Bendel, Anne E, Ellezam, Benjamin, Gerber, Nicholas, Plant, Ashley, Jeffery, Rubens, Dunham, Christopher, Moertel, Christopher, Walter, Andrew, Ziegler, David, Dodgshun, Andrew, Gottardo, Nicholas, Demir, Ahmet, Ramanujachar, Ramya, Raabe, Eric, Mary, Shago, Dirks, Peter, Taylor, Michael, Eugene, Hwang, Lindsey, Holly, Tihan, Tarik, Mette, Jorgensen, Dahl, Christine, Low, Sharon, Smith, Amy, Hazrati, Lili-Naz, Kresak, Jesse, Gino, Somers, Tan, Enrica, Morales, Andres, Santa-Maria, Vicente, Hawkins, Cynthia, Bartels, Ute, Stephens, Derek, Nobusawa, Sumihito, Dufour, Christelle, Bourdeaut, Franck, Andre, Nicolas, Bouffet, Eric, Huang, Annie

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Phase 1/2 KEYNOTE-051 study of pembrolizumab (pembro) in pediatric patients (pts) with advanced melanoma or a PD-L1 + advanced, relapsed, or refractory solid tumor or lymphoma von Geoerger, Birgit, Kang, Hyoung Jin, Yalon-Oren, Michal, Marshall, Lynley V., Vezina, Catherine, Pappo, Alberto S., Laetsch, Theodore Willis, Petrilli, Antonio Sergio, Handgretinger, Rupert, Toporski, Jacek, Glade-Bender, Julia, Nicholls, Wayne, Fox, Elizabeth, DuBois, Steven G., Macy, Margaret, Cohn, Susan Lerner, Pathiraja, Kumudu, Diede, Scott J., Ebbinghaus, Scot, Pinto, Navin R.

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Clinical phenotypes and prognostic features of embryonal tumours with multi-layered rosettes: a Rare Brain Tumor Registry study von Khan, Sara, Solano-Paez, Palma, Suwal, Tannu, Lu, Mei, Al-Karmi, Salma, Ho, Ben, Mumal, Iqra, Shago, Mary, Dodgshun, Andrew, Tabori, Uri, Bartels, Ute, Ziegler, David S, Hansford, Jordan R, Ramaswamy, Vijay, Hawkins, Cynthia, Dufour, Christelle, André, Nicolas, Bouffet, Eric, Huang, Annie, Leary, Sarah, Thacker, Nirav, Li, Bryan K., Lindsay, Holly B., Lassaletta, Alvaro, Moertel, Christopher, Morales La Madrid, Andres, Santa-Maria, Vicente, Rivas, Eloy, Ellezam, Benjamin, Weil, Alexander G, Jabado, Nada, Oviedo, Angelica, Yalon-Oren, Michal, Amariglio, Laura, Loukides, James, Van Meter, Timothy E., Wu, Kuo-Sheng, Ra, Young-Shin, Massimi, Luca, Buccoliero, Anna Maria, Li, Rong, Gillespie, G. Yancey, Adamek, Dariusz, Fangusaro, Jason, Scharnhorst, David, Torkildson, Joseph, Johnston, Donna, Michaud, Jean, Chan, Jennifer, Wilson, Beverly, Camelo-Piragua, Sandra, Hanson, Derek, Jacobsen, Chad, Wright, Karen, Vibhakar, Rajeev, Wang, Yin, Gerber, Nicholas, Grotzer, Michael A., Shen, Violet, Plant, Ashley, Dunham, Christopher, Joao Gil da Costa, Maria, Raabe, Eric, Rubens, Jeffery, Dahl, Christine, Jorgensen, Mette, Hwang, Eugene I., Packer, Roger J, Smith, Amy, Tan, Enrica, Low, Sharon, Lu, Jian-Qiang, Ng, Ho- Keung, Sirachainan, Nongnuch, Hongeng, Suradej, Magimairajan, Vanan, Sinha, Roona, Mushtaq, Naureen, Antony, Reuben, Afzal, Samina, Walter, Andrew, Tihan, Tarik, Wood, Paul, Cain, Jason E., Gottardo, Nicolas, Branson, Helen, Laughlin, Suzanne, Ertl-Wagner, Birgit, Kulkarni, Abhaya V., Taylor, Michael D., Ibrahim, George M., Dirks, Peter B., Rutka, James T., Somers, Gino R., Hazrati, Lili-Naz, Bourdeaut, Franck, Padovani, Laetitia, Grundy, Richard G., Mazewski, Claire M., Fouladi, Maryam

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Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial von Kilburn, Lindsay B, Khuong-Quang, Dong-Anh, Hansford, Jordan R, Landi, Daniel, van der Lugt, Jasper, Leary, Sarah ES, Driever, Pablo Hernaiz, Bailey, Simon, Perreault, Sebastien, McCowage, Geoffrey, Waanders, Angela J, Ziegler, David S, Witt, Olaf, Baxter, Patricia A, Kang, Hyoung Jin, Hassall, Timothy E, Han, Jung Woo, Hargrave, Darren, Franson, Andrea T, Yalon Oren, Michal, Toledano, Helen, Larouche, Valerie, Kline, Cassie, Abdelbaki, Mohamed S, Jabado, Nada, Gottardo, Nicholas G, Gerber, Nicolas U, Whipple, Nicholas S, Segal, Devorah, Chi, Susan N, Oren, Liat, Tan, Enrica EK, Mueller, Sabine, Cornelio, Izzy, Mcleod, Lisa, Zhao, Xin, Walter, Ashley, Da Costa, Daniel, Manley, Peter, Blackman, Samuel C, Packer, Roger J, Nysom, Karsten

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Pediatric glioblastoma cells are sensitive to drugs that inhibit eIF2α dephosphorylation and its phosphomimetic S51D variant von Eytan, Karin, Versano, Ziv, Oren, Roni, Jacob-Hirsch, Jasmine, Leitner, Moshe, Harmelin, Alon, Rechavi, Gideon, Toren, Amos, Paglin, Shoshana, Yalon, Michal

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