A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface von de Jong, Rob N, Beurskens, Frank J, Verploegen, Sandra, Strumane, Kristin, van Kampen, Muriel D, Voorhorst, Marleen, Horstman, Wendy, Engelberts, Patrick J, Oostindie, Simone C, Wang, Guanbo, Heck, Albert J R, Schuurman, Janine, Parren, Paul W H I

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Avidity in antibody effector functions and biotherapeutic drug design von Oostindie, Simone C., Lazar, Greg A., Schuurman, Janine, Parren, Paul W. H. I.

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DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing von Engelberts, Patrick J., Hiemstra, Ida H., de Jong, Bart, Schuurhuis, Danita H., Meesters, Joyce, Beltran Hernandez, Irati, Oostindie, Simone C., Neijssen, Joost, van den Brink, Edward N., Horbach, G. Jean, Verploegen, Sandra, Labrijn, Aran F., Salcedo, Theodora, Schuurman, Janine, Parren, Paul W.H.I, Breij, Esther C.W.

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CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering von Oostindie, Simone C, van der Horst, Hilma J, Lindorfer, Margaret A, Cook, Erika M, Tupitza, Jillian C, Zent, Clive S, Burack, Richard, VanDerMeid, Karl R, Strumane, Kristin, Chamuleau, Martine E D, Mutis, Tuna, de Jong, Rob N, Schuurman, Janine, Breij, Esther C W, Beurskens, Frank J, Parren, Paul W H I, Taylor, Ronald P

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Logic-gated antibody pairs that selectively act on cells co-expressing two antigens von Oostindie, Simone C., Rinaldi, Derek A., Zom, Gijs G., Wester, Michael J., Paulet, Desiree, Al-Tamimi, Kusai, van der Meijden, Els, Scheick, Jennifer R., Wilpshaar, Tessa, de Jong, Bart, Hoff-van den Broek, Marloes, Grattan, Rachel M., Oosterhoff, Janita J., Vignau, Julie, Verploegen, Sandra, Boross, Peter, Beurskens, Frank J., Lidke, Diane S., Schuurman, Janine, de Jong, Rob N.

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DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies von Oostindie, Simone C., van der Horst, Hilma J., Kil, Laurens P., Strumane, Kristin, Overdijk, Marije B., van den Brink, Edward N., van den Brakel, Jeroen H. N., Rademaker, Hendrik J., van Kessel, Berris, van den Noort, Juliette, Chamuleau, Martine E. D., Mutis, Tuna, Lindorfer, Margaret A., Taylor, Ronald P., Schuurman, Janine, Parren, Paul W. H. I., Beurskens, Frank J., Breij, Esther C. W.

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Cyton2: A Model of Immune Cell Population Dynamics That Includes Familial Instructional Inheritance von Cheon, HoChan, Kan, Andrey, Prevedello, Giulio, Oostindie, Simone C, Dovedi, Simon J, Hawkins, Edwin D, Marchingo, Julia M, Heinzel, Susanne, Duffy, Ken R, Hodgkin, Philip D

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Potent Preclinical Efficacy of DuoHexaBody‐CD37 in B‐Cell Malignancies von Horst, Hilma J., Oostindie, Simone C., Cillessen, Saskia. A. G. M., Gelderloos, Anne T., Overdijk, Marije B., Nijhof, Inger. S., Zweegman, Sonja, Chamuleau, Martine E. D., Breij, Esther C. W., Mutis, Tuna

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Duobody-CD3xCD30 Demonstrates Potent Anti-Tumor Activity in Preclinical Models of CD30+ Hematologic Malignancies von Oostindie, Simone C., Alemdehy, Mir Farshid, Janmaat, Maarten L., Meerding, Jenny M., Kemper, Kristel, Engelberts, Patrick J., De Goeij, Bart E.C.G., Satijn, David, Sasser, A. Kate, Breij, Esther C.W.

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Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions von Cook, Erika M, Lindorfer, Margaret A, van der Horst, Hilma, Oostindie, Simone, Beurskens, Frank J, Schuurman, Janine, Zent, Clive S, Burack, Richard, Parren, Paul W H I, Taylor, Ronald P

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Impact of carbamylation on IgG mediated complement activation von Lubbers, Rosalie, Oostindie, Simone C., Parren, Paul W., Beurskens, Frank J., Trouw, Leendert A.

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Hexamerization-enhanced CD37 and CD20 antibodies synergize in CDC to kill patient-derived CLL cells with unprecedented potency von Taylor, Ronald, Lindorfer, Margaret, Oostindie, Simone, Cook, Erika, Zent, Clive, Burack, Richard, Beurskens, Frank, Schuurman, Janine, Breij, Esther, Parren, Paul

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Abstract 4544: Multifaceted mechanism of action of DuoHexaBody-CD37 involves both complement- and Fc gamma receptor-mediated cytotoxicity in pre-clinical B-cell lymphoma models von Kil, Laurens P., Oostindie, Simone C., Strumane, Kristin, van der Horst, Hilma J., van Kessel, Berris, Overdijk, Marije B., Lingnau, Andreas, Brandhorst, Marcel, van den Brakel, Jeroen, Lindorfer, Margaret A., Taylor, Ronald P., Chamuleau, Martine E., Mutis, Tuna, Sasser, A. Kate, Schuurman, Janine, Parren, Paul W., Beurskens, Frank J., Breij, Esther C.

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Targeting CD37 in B-Cell Malignancies Using the Novel Therapeutic Duohexabody-CD37 Results in Efficient Killing of Tumor B-Cells Ex Vivo Via Complement-Dependent Cytotoxicity, Even... von Van Der Horst, Hilma J., Oostindie, Simone C., Cillessen, Saskia AGM, Gelderloos, Anne T, Overdijk, Marije B, Chamuleau, Martine E.D., Breij, Esther C.W., Mutis, Tuna

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Duohexabody-CD37, a Novel Bispecific Antibody with a Hexamerization-Enhancing Mutation Targeting CD37, Demonstrates Superior Complement-Dependent Cytotoxicity in Preclinical B-Cell... von Oostindie, Simone C., Van Der Horst, Hilma J., Overdijk, Marije B., Strumane, Kristin, Verploegen, Sandra, Lindorfer, Margaret A., Cook, Erica M., Chamuleau, Martine E.D., Mutis, Tuna, Schuurman, Janine, Sasser, A. Kate, Taylor, Ronald P., Parren, Paul W. H.I., Beurskens, Frank J., Breij, Esther C.W.

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A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface: e1002344 von Jong, Rob Nde, Beurskens, Frank J, Verploegen, Sandra, Strumane, Kristin, Kampen, Muriel Dvan, Voorhorst, Marleen, Horstman, Wendy, Engelberts, Patrick J, Oostindie, Simone C, Wang, Guanbo, Heck, Albert JR, Schuurman, Janine, Parren, W HI

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A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface von de Jong, Rob N, Beurskens, Frank J, Verploegen, Sandra, Strumane, Kristin, van Kampen, Muriel D, Voorhorst, Marleen, Horstman, Wendy, Engelberts, Patrick J, Oostindie, Simone C, Wang, Guanbo, Heck, Albert J R, Schuurman, Janine, Parren, Paul W H I

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Antibodies that efficiently form hexamers upon antigen binding can induce complement-dependent cytotoxicity under complement-limiting conditions von Taylor, Ronald P, Lindorfer, Margaret A, Cook, Erika M, Beurskens, Frank J, van der Horst, Hilma, Oostindie, Simone, Schuurman, Janine, Zent, Clive, Burack, Richard, Parren, Paul W.H.I

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ANTIBODIES BINDING TO CD30 AND CD3 von ENGELBERTS, Patrick, KEMPER, Kristel, SATIJN, David, BREIJ, Esther, C, W, ALEMDEHY, Farshid, OOSTINDIE, Simone

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ANTIBODIES BINDING TO CD30 AND CD3 von ENGELBERTS, Patrick, KEMPER, Kristel, BREIJ, Esther C. W, SATIJN, David, ALEMDEHY, Farshid, OOSTINDIE, Simone

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