Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer von Olsen, Shaun K., Lima, Christopher D.

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Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design von Rut, Wioletta, Lv, Zongyang, Zmudzinski, Mikolaj, Patchett, Stephanie, Nayak, Digant, Snipas, Scott J, El Oualid, Farid, Huang, Tony T, Bekes, Miklos, Drag, Marcin, Olsen, Shaun K

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PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis von Yin, Shasha, Liu, Liu, Brobbey, Charles, Palanisamy, Viswanathan, Ball, Lauren E., Olsen, Shaun K., Ostrowski, Michael C., Gan, Wenjian

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Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity von Lv, Dongwen, Pal, Pratik, Liu, Xingui, Jia, Yannan, Thummuri, Dinesh, Zhang, Peiyi, Hu, Wanyi, Pei, Jing, Zhang, Qi, Zhou, Shuo, Khan, Sajid, Zhang, Xuan, Hua, Nan, Yang, Qingping, Arango, Sebastian, Zhang, Weizhou, Nayak, Digant, Olsen, Shaun K., Weintraub, Susan T., Hromas, Robert, Konopleva, Marina, Yuan, Yaxia, Zheng, Guangrong, Zhou, Daohong

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Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI von Yuan, Lingmin, Lv, Zongyang, Atkison, James H., Olsen, Shaun K.

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A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease von Patchett, Stephanie, Lv, Zongyang, Rut, Wioletta, Békés, Miklos, Drag, Marcin, Olsen, Shaun K., Huang, Tony T.

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Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral Development von Lv, Zongyang, Cano, Kristin E, Jia, Lijia, Drag, Marcin, Huang, Tony T, Olsen, Shaun K

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Structural basis for adenylation and thioester bond formation in the ubiquitin E1 von Hann, Zachary S., Ji, Cheng, Olsen, Shaun K., Lu, Xuequan, Lux, Michaelyn C., Tan, Derek S., Lima, Christopher D.

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Crystal structures of an E1–E2–ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification von Yuan, Lingmin, Lv, Zongyang, Adams, Melanie J., Olsen, Shaun K.

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Structural basis for fibroblast growth factor receptor activation von Mohammadi, Moosa, Olsen, Shaun K., Ibrahimi, Omar A.

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Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL von Nayak, Digant, Lv, Dongwen, Yuan, Yaxia, Zhang, Peiyi, Hu, Wanyi, Nayak, Anindita, Ruben, Eliza A., Lv, Zongyang, Sung, Patrick, Hromas, Robert, Zheng, Guangrong, Zhou, Daohong, Olsen, Shaun K.

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Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34 von Williams, Katelyn M., Qie, Shuo, Atkison, James H., Salazar-Arango, Sabrina, Alan Diehl, J., Olsen, Shaun K.

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Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme von Lv, Zongyang, Yuan, Lingmin, Atkison, James H., Williams, Katelyn M., Vega, Ramir, Sessions, E. Hampton, Divlianska, Daniela B., Davies, Christopher, Chen, Yuan, Olsen, Shaun K.

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Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase von Zmudzinski, Mikolaj, Rut, Wioletta, Olech, Kamila, Granda, Jarosław, Giurg, Mirosław, Burda-Grabowska, Małgorzata, Kaleta, Rafał, Zgarbova, Michala, Kasprzyk, Renata, Zhang, Linlin, Sun, Xinyuanyuan, Lv, Zongyang, Nayak, Digant, Kesik-Brodacka, Malgorzata, Olsen, Shaun K., Weber, Jan, Hilgenfeld, Rolf, Jemielity, Jacek, Drag, Marcin

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Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer von Afsar, Mohammad, Liu, GuanQun, Jia, Lijia, Ruben, Eliza A., Nayak, Digant, Sayyad, Zuberwasim, Bury, Priscila dos Santos, Cano, Kristin E., Nayak, Anindita, Zhao, Xiang Ru, Shukla, Ankita, Sung, Patrick, Wasmuth, Elizabeth V., Gack, Michaela U., Olsen, Shaun K.

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Domain alternation and active site remodeling are conserved structural features of ubiquitin E1 von Lv, Zongyang, Yuan, Lingmin, Atkison, James H., Aldana-Masangkay, Grace, Chen, Yuan, Olsen, Shaun K.

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Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts von Strub, Daniel Jan, Talma, Michał, Strub, Maria, Rut, Wioletta, Zmudzinski, Mikolaj, Brud, Władysław, Neyts, Johan, Vangeel, Laura, Zhang, Linlin, Sun, Xinyuanyuan, Lv, Zongyang, Nayak, Digant, Olsen, Shaun K., Hilgenfeld, Rolf, Jochmans, Dirk, Drąg, Marcin

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Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of Fibroblast Growth Factor 19 Subfamily Members von Goetz, Regina, Beenken, Andrew, Ibrahimi, Omar A., Kalinina, Juliya, Olsen, Shaun K., Eliseenkova, Anna V., Xu, ChongFeng, Neubert, Thomas A., Zhang, Fuming, Linhardt, Robert J., Yu, Xijie, White, Kenneth E., Inagaki, Takeshi, Kliewer, Steven A., Yamamoto, Masaya, Kurosu, Hiroshi, Ogawa, Yasushi, Kuro-o, Makoto, Lanske, Beate, Razzaque, Mohammed S., Mohammadi, Moosa

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Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6 von Yuan, Lingmin, Gao, Fei, Lv, Zongyang, Nayak, Digant, Nayak, Anindita, Santos Bury, Priscila dos, Cano, Kristin E., Jia, Lijia, Oleinik, Natalia, Atilgan, Firdevs Cansu, Ogretmen, Besim, Williams, Katelyn M., Davies, Christopher, El Oualid, Farid, Wasmuth, Elizabeth V., Olsen, Shaun K.

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Crystal Structures of an E1‐E2‐ubiquitin Thioester Mimetic Reveal Molecular Mechanisms of Transthioesterification von Olsen, Shaun K.

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