The Role of MDM2 Amplification and Overexpression in Tumorigenesis von Oliner, Jonathan D, Saiki, Anne Y, Caenepeel, Sean

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The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents von Canon, Jude, Osgood, Tao, Olson, Steven H, Saiki, Anne Y, Robertson, Rebecca, Yu, Dongyin, Eksterowicz, John, Ye, Qiuping, Jin, Lixia, Chen, Ada, Zhou, Jing, Cordover, David, Kaufman, Stephen, Kendall, Richard, Oliner, Jonathan D, Coxon, Angela, Radinsky, Robert

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Complementary Actions of Inhibitors of Angiopoietin-2 and VEGF on Tumor Angiogenesis and Growth von HASHIZUME, Hiroya, FALCON, Beverly L, KURODA, Takashi, BALUK, Peter, COXON, Angela, DONGYIN YU, BREADY, James V, OLINER, Jonathan D, MCDONALD, Donald M

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Contrasting Actions of Selective Inhibitors of Angiopoietin-1 and Angiopoietin-2 on the Normalization of Tumor Blood Vessels von Falcón, Beverly L, Hashizume, Hiroya, Koumoutsakos, Petros, Chou, Jeyling, Bready, James V, Coxon, Angela, Oliner, Jonathan D, McDonald, Donald M

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Safety, Pharmacokinetics, and Antitumor Activity of AMG 386, a Selective Angiopoietin Inhibitor, in Adult Patients With Advanced Solid Tumors von HERBST, Roy S, HONG, David, EVELHOCH, Jeffrey L, OLINER, Jonathan D, LE, Ngocdiep, ROSEN, Lee S, LINNEA CHAP, KURZROCK, Razelle, JACKSON, Edward, SILVERMAN, Jeffrey M, RASMUSSEN, Erik, SUN, Yu-Nien, DON ZHONG, HWANG, Yuying C

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Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction von Rew, Yosup, Sun, Daqing, Gonzalez-Lopez De Turiso, Felix, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Deignan, Jeffrey, Fox, Brian M, Gustin, Darin, Huang, Xin, Jiang, Min, Jiao, Xianyun, Jin, Lixia, Kayser, Frank, Kopecky, David J, Li, Yihong, Lo, Mei-Chu, Long, Alexander M, Michelsen, Klaus, Oliner, Jonathan D, Osgood, Tao, Ragains, Mark, Saiki, Anne Y, Schneider, Steve, Toteva, Maria, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H

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Selective and Potent Morpholinone Inhibitors of the MDM2–p53 Protein–Protein Interaction von Gonzalez, Ana Z, Eksterowicz, John, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Duquette, Jason, Fox, Brian M, Fu, Jiasheng, Huang, Xin, Houze, Jonathan B, Jin, Lixia, Li, Yihong, Li, Zhihong, Ling, Yun, Lo, Mei-Chu, Long, Alexander M, McGee, Lawrence R, McIntosh, Joel, McMinn, Dustin L, Oliner, Jonathan D, Osgood, Tao, Rew, Yosup, Saiki, Anne Y, Shaffer, Paul, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Olson, Steven H, Medina, Julio C, Sun, Daqing

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REDD1, a Developmentally Regulated Transcriptional Target of p63 and p53, Links p63 to Regulation of Reactive Oxygen Species von Ellisen, Leif W, Ramsayer, Kate D, Johannessen, Cory M, Yang, Annie, Beppu, Hideyuki, Minda, Karolina, Oliner, Jonathan D, McKeon, Frank, Haber, Daniel A

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Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody von Coxon, Angela, Bready, James, Min, Hosung, Kaufman, Stephen, Leal, Juan, Yu, Dongyin, Lee, Tani Ann, Sun, Ji-Rong, Estrada, Juan, Bolon, Brad, McCabe, James, Wang, Ling, Rex, Karen, Caenepeel, Sean, Hughes, Paul, Cordover, David, Kim, Haejin, Han, Seog Joon, Michaels, Mark L, Hsu, Eric, Shimamoto, Grant, Cattley, Russell, Hurh, Eunju, Nguyen, Linh, Wang, Shao Xiong, Ndifor, Anthony, Hayward, Isaac J, Falcón, Beverly L, McDonald, Donald M, Li, Luke, Boone, Tom, Kendall, Richard, Radinsky, Robert, Oliner, Jonathan D

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Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors von Gonzalez-Lopez de Turiso, Felix, Sun, Daqing, Rew, Yosup, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Correll, Tiffany L, Huang, Xin, Julian, Lisa D, Kayser, Frank, Lo, Mei-Chu, Long, Alexander M, McMinn, Dustin, Oliner, Jonathan D, Osgood, Tao, Powers, Jay P, Saiki, Anne Y, Schneider, Steve, Shaffer, Paul, Xiao, Shou-Hua, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H

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Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1 von Harkin, D.Paul, Bean, James M, Miklos, David, Song, Young-Han, Truong, Vivi B, Englert, Christoph, Christians, Fred C, Ellisen, Leif W, Maheswaran, Shyamala, Oliner, Jonathan D, Haber, Daniel A

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The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin von Lee, S B, Huang, K, Palmer, R, Truong, V B, Herzlinger, D, Kolquist, K A, Wong, J, Paulding, C, Yoon, S K, Gerald, W, Oliner, J D, Haber, D A

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Label-free fluorescence lifetime imaging for the assessment of cell viability in living tumor fragments von Smith, Jason T., Liu, Chao J., Degnan, Jeannine, Ouellette, Jonathan N., Conklin, Matthew W., Kellner, Anna V., Scribano, Christina M., Hrycyniak, Laura, Oliner, Jonathan D., Zahm, Chris, Wait, Eric, Eliceiri, Kevin W., Rafter, John

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Assessing cell viability with dynamic optical coherence microscopy von Liu, Chao J, Smith, Jason T, Wang, Yuanbo, Ouellette, Jonathan N, Rogers, Jeremy D, Oliner, Jonathan D, Szulczewski, Michael, Wait, Eric, Brown, William, Wax, Adam, Eliceiri, Kevin W, Rafter, John

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Identifying the determinants of response to MDM2 inhibition von Saiki, Anne Y, Caenepeel, Sean, Cosgrove, Elissa, Su, Cheng, Boedigheimer, Michael, Oliner, Jonathan D

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Discovery and Optimization of Chromenotriazolopyrimidines as Potent Inhibitors of the Mouse Double Minute 2−Tumor Protein 53 Protein−Protein Interaction von Allen, John G, Bourbeau, Matthew P, Wohlhieter, G. Erich, Bartberger, Michael D, Michelsen, Klaus, Hungate, Randall, Gadwood, Robert C, Gaston, Rick D, Evans, Bruce, Mann, Larry W, Matison, Michael E, Schneider, Stephen, Huang, Xin, Yu, Dongyin, Andrews, Paul S, Reichelt, Andreas, Long, Alexander M, Yakowec, Peter, Yang, Evelyn Y, Lee, Tani Ann, Oliner, Jonathan D

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Abstract 3761: The MDM2 inhibitor AMG 232 causes tumor regression and potentiates the anti-tumor activity of MEK inhibition and DNA-damaging cytotoxic agents in preclinical models... von Canon, Jude R., Osgood, Tao, Saiki, Anne Y., Oliner, Jonathan D.

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Discovery of AM-7209, a Potent and Selective 4‑Amidobenzoic Acid Inhibitor of the MDM2–p53 Interaction von Rew, Yosup, Sun, Daqing, Yan, Xuelei, Beck, Hilary P, Canon, Jude, Chen, Ada, Duquette, Jason, Eksterowicz, John, Fox, Brian M, Fu, Jiasheng, Gonzalez, Ana Z, Houze, Jonathan, Huang, Xin, Jiang, Min, Jin, Lixia, Li, Yihong, Li, Zhihong, Ling, Yun, Lo, Mei-Chu, Long, Alexander M, McGee, Lawrence R, McIntosh, Joel, Oliner, Jonathan D, Osgood, Tao, Saiki, Anne Y, Shaffer, Paul, Wang, Yu Chung, Wortman, Sarah, Yakowec, Peter, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H

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E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis von Müller, H, Bracken, A P, Vernell, R, Moroni, M C, Christians, F, Grassilli, E, Prosperini, E, Vigo, E, Oliner, J D, Helin, K

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Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres von Gonzalez, Ana Z, Li, Zhihong, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Duquette, Jason, Eksterowicz, John, Fox, Brian M, Fu, Jiasheng, Huang, Xin, Houze, Jonathan, Jin, Lixia, Li, Yihong, Ling, Yun, Lo, Mei-Chu, Long, Alexander M, McGee, Lawrence R, McIntosh, Joel, Oliner, Jonathan D, Osgood, Tao, Rew, Yosup, Saiki, Anne Y, Shaffer, Paul, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Olson, Steven H, Sun, Daqing, Medina, Julio C

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