Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors von McAulay, Kirsten, Hoyt, Emily A., Thomas, Morgan, Schimpl, Marianne, Bodnarchuk, Michael S., Lewis, Hilary J., Barratt, Derek, Bhavsar, Deepa, Robinson, David M., Deery, Michael J., Ogg, Derek J., Bernardes, Goncalo J. L., Ward, Richard A., Waring, Michael J., Kettle, Jason G.

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Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B von Vögtle, Timo, Sharma, Sumana, Mori, Jun, Nagy, Zoltan, Semeniak, Daniela, Scandola, Cyril, Geer, Mitchell J, Smith, Christopher W, Lane, Jordan, Pollack, Scott, Lassila, Riitta, Jouppila, Annukka, Barr, Alastair J, Ogg, Derek J, Howard, Tina D, McMiken, Helen J, Warwicker, Juli, Geh, Catherine, Rowlinson, Rachel, Abbott, W Mark, Eckly, Anita, Schulze, Harald, Wright, Gavin J, Mazharian, Alexandra, Fütterer, Klaus, Rajesh, Sundaresan, Douglas, Michael R, Senis, Yotis A

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Novel Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor with Reduced Acyl Glucuronide Liability: The Discovery of 4‑[4-(2-Adamantylcarbamoyl)-5-tert-butyl-pyrazol... von Scott, James S, deSchoolmeester, Joanne, Kilgour, Elaine, Mayers, Rachel M, Packer, Martin J, Hargreaves, David, Gerhardt, Stefan, Ogg, Derek J, Rees, Amanda, Selmi, Nidhal, Stocker, Andrew, Swales, John G, Whittamore, Paul R. O

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Structural Basis of Pilus Subunit Recognition by the PapD Chaperone von Kuehn, Meta J., Ogg, Derek J., Kihlberg, Jan, Slonim, Lynn N., Flemmer, Katarina, Bergfors, Terese, Hultgren, Scott J.

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Structures of the hydrolase domain of human 10-formyltetrahydrofolate dehydrogenase and its complex with a substrate analogue von Schüler, Herwig, Ogg, Derek J., Flodin, Susanne, Kursula, Petri, Nilsson-Ehle, Petra, Savitsky, Pavel, Stenmark, Pål, Nordlund, Pär

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Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets – the discovery of AZD3651 and AZD9485 von Waring, Michael J., Bennett, Stuart N. L., Boyd, Scott, Campbell, Leonie, Davies, Robert D. M., Hargreaves, David, MacFaul, Philip, Martin, Nathaniel G., Ogg, Derek J., Robb, Graeme R., Wilkinson, Gary, Wood, J. Matthew

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Identification and optimisation of 3,3-dimethyl-azetidin-2-ones as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Electronic supplementary inf... von McCoull, William, Augustin, Martin, Blake, Caroline, Ertan, Anne, Kilgour, Elaine, Krapp, Stephan, Moore, Jane E, Newcombe, Nicholas J, Packer, Martin J, Rees, Amanda, Revill, John, Scott, James S, Selmi, Nidhal, Gerhardt, Stefan, Ogg, Derek J, Steinbacher, Stefan, Whittamore, Paul R. O

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Identification and optimisation of 3,3-dimethyl-azetidin-2-ones as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) von McCoull, William, Augustin, Martin, Blake, Caroline, Ertan, Anne, Kilgour, Elaine, Krapp, Stephan, Moore, Jane E., Newcombe, Nicholas J., Packer, Martin J., Rees, Amanda, Revill, John, Scott, James S., Selmi, Nidhal, Gerhardt, Stefan, Ogg, Derek J., Steinbacher, Stefan, Whittamore, Paul R. O.

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Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets - the discovery of AZD3651 and AZD9485Electronic supplementary information (ESI) available... von Waring, Michael J, Bennett, Stuart N. L, Boyd, Scott, Campbell, Leonie, Davies, Robert D. M, Hargreaves, David, MacFaul, Philip, Martin, Nathaniel G, Ogg, Derek J, Robb, Graeme R, Wilkinson, Gary, Wood, J. Matthew

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Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors von McAulay, Kirsten, Hoyt, Emily A, Thomas, Morgan, Schimpl, Marianne, Bodnarchuk, Michael S, Lewis, Hilary J, Barratt, Derek, Bhavsar, Deepa, Robinson, David M, Deery, Michael J, Ogg, Derek J, Bernardes, Gonçalo JL, Ward, Richard A, Waring, Michael J, Kettle, Jason G

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Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B von Vögtle, Timo, Sharma, Sumana, Mori, Jun, Nagy, Zoltan, Semeniak, Daniela, Scandola, Cyril, Geer, Mitchell J, Smith, Christopher W, Lane, Jordan, Pollack, Scott, Lassila, Riitta, Jouppila, Annukka, Barr, Alastair J, Ogg, Derek J, Howard, Tina D, McMiken, Helen J, Warwicker, Juli, Geh, Catherine, Rowlinson, Rachel, Abbott, W Mark, Eckly, Anita, Schulze, Harald, Wright, Gavin J, Mazharian, Alexandra, Fütterer, Klaus, Rajesh, Sundaresan, Douglas, Michael R, Senis, Yotis A

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Crystallization and preliminary X-ray diffraction studies of a new crystal form of human secretory type IIA phospholipase A 2 von Church, W. Bret, Lei, Pei-Wen, Ogg, Derek J., Scott, Kieran F.

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Crystallization and preliminary X-ray diffraction studies of a new crystal form of human secretory type IIA phospholipase A2 von Church, W. Bret, Lei, Pei-Wen, Ogg, Derek J., Scott, Kieran F.

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Purification and preliminary characterization of phosphoglycerate mutase from Schizosaccharomyces pombe von Price, Nicholas C., Duncan, Doris, Ogg, Derek J.

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Potent and selective bivalent inhibitors of BET bromodomains von Waring, Michael J, Chen, Huawei, Rabow, Alfred A, Walker, Graeme, Bobby, Romel, Boiko, Scott, Bradbury, Rob H, Callis, Rowena, Clark, Edwin, Dale, Ian, Daniels, Danette L, Dulak, Austin, Flavell, Liz, Holdgate, Geoff, Jowitt, Thomas A, Kikhney, Alexey, McAlister, Mark, Méndez, Jacqui, Ogg, Derek, Patel, Joe, Petteruti, Philip, Robb, Graeme R, Robers, Matthew B, Saif, Sakina, Stratton, Natalie, Svergun, Dmitri I, Wang, Wenxian, Whittaker, David, Wilson, David M, Yao, Yi

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Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS(G12C) von Kettle, Jason G., Bagal, Sharan K., Bickerton, Sue, Bodnarchuk, Michael S., Breed, Jason, Carbajo, Rodrigo J., Cassar, Doyle J., Chakraborty, Atanu, Cosulich, Sabina, Cumming, Iain, Davies, Michael, Eatherton, Andrew, Evans, Laura, Feron, Lyman, Fillery, Shaun, Gleave, Emma S., Goldberg, Frederick W., Harlfinger, Stephanie, Hanson, Lyndsey, Howard, Martin, Howells, Rachel, Jackson, Anne, Kemmitt, Paul, Kingston, Jennifer K., Lamont, Scott, Lewis, Hilary J., Li, Songlei, Liu, Libin, Ogg, Derek, Phillips, Christopher, Polanski, Radek, Robb, Graeme, Robinson, David, Ross, Sarah, Smith, James M., Tonge, Michael, Whiteley, Rebecca, Yang, Junsheng, Zhang, Longfei, Zhao, Xiliang

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Discovery of N‑(4-{[5-Fluoro-7-(2-methoxyethoxy)­quinazolin-4-yl]amino}­phenyl)-2-[4-(propan-2-yl)‑1H‑1,2,3-triazol-1-yl]­acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for... von Kettle, Jason G, Anjum, Rana, Barry, Evan, Bhavsar, Deepa, Brown, Crystal, Boyd, Scott, Campbell, Andrew, Goldberg, Kristin, Grondine, Michael, Guichard, Sylvie, Hardy, Christopher J, Hunt, Tom, Jones, Rhys D. O, Li, Xiuwei, Moleva, Olga, Ogg, Derek, Overman, Ross C, Packer, Martin J, Pearson, Stuart, Schimpl, Marianne, Shao, Wenlin, Smith, Aaron, Smith, James M, Stead, Darren, Stokes, Steve, Tucker, Michael, Ye, Yang

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Structure of human semicarbazide-sensitive amine oxidase/vascular adhesion protein-­1 von Nilsson, Joakim, Ogg, Derek, Jakobsson, Emma, Kleywegt, Gerard J.

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Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS G12C von Kettle, Jason G, Bagal, Sharan K, Bickerton, Sue, Bodnarchuk, Michael S, Breed, Jason, Carbajo, Rodrigo J, Cassar, Doyle J, Chakraborty, Atanu, Cosulich, Sabina, Cumming, Iain, Davies, Michael, Eatherton, Andrew, Evans, Laura, Feron, Lyman, Fillery, Shaun, Gleave, Emma S, Goldberg, Frederick W, Harlfinger, Stephanie, Hanson, Lyndsey, Howard, Martin, Howells, Rachel, Jackson, Anne, Kemmitt, Paul, Kingston, Jennifer K, Lamont, Scott, Lewis, Hilary J, Li, Songlei, Liu, Libin, Ogg, Derek, Phillips, Christopher, Polanski, Radek, Robb, Graeme, Robinson, David, Ross, Sarah, Smith, James M, Tonge, Michael, Whiteley, Rebecca, Yang, Junsheng, Zhang, Longfei, Zhao, Xiliang

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Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor: Discovery of 2-[(3S)-1-[5-(Cyclohexylcarbamoyl)-6-pro... von Scott, James S, Bowker, Suzanne S, deSchoolmeester, Joanne, Gerhardt, Stefan, Hargreaves, David, Kilgour, Elaine, Lloyd, Adele, Mayers, Rachel M, McCoull, William, Newcombe, Nicholas J, Ogg, Derek, Packer, Martin J, Rees, Amanda, Revill, John, Schofield, Paul, Selmi, Nidhal, Swales, John G, Whittamore, Paul R. O

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