Protein Phosphatase 2A as a Therapeutic Target in Acute Myeloid Leukemia von Arriazu, Elena, Pippa, Raffaella, Odero, María D

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Set Protein Is Involved in FLT3 Membrane Trafficking von Marcotegui, Nerea, Romero-Murillo, Silvia, Marco-Sanz, Javier, Peris, Irene, Berrozpe, Blanca S, Vicente, Carmen, Odero, María D, Arriazu, Elena

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Downregulation of PPP2R5E is a common event in acute myeloid leukemia that affects the oncogenic potential of leukemic cells von Cristóbal, Ion, Cirauqui, Cristina, Castello-Cros, Remedios, Garcia-Orti, Laura, Calasanz, María J, Odero, María D

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Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas von Alonso, Marta M, Diez-Valle, Ricardo, Manterola, Lorea, Rubio, Angel, Liu, Dan, Cortes-Santiago, Nahir, Urquiza, Leire, Jauregi, Patricia, Lopez de Munain, Adolfo, Sampron, Nicolás, Aramburu, Ander, Tejada-Solís, Sonia, Vicente, Carmen, Odero, María D, Bandrés, Eva, García-Foncillas, Jesús, Idoate, Miguel A, Lang, Frederick F, Fueyo, Juan, Gomez-Manzano, Candelaria

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Antagonism of SET Using OP449 Enhances the Efficacy of Tyrosine Kinase Inhibitors and Overcomes Drug Resistance in Myeloid Leukemia von AGARWAL, Anupriya, MACKENZIE, Ryan J, DRUKER, Brian J, PIPPA, Raffaella, EIDE, Christopher A, ODDO, Jessica, TYNER, Jeffrey W, SEARS, Rosalie, VITEK, Michael P, ODERO, Maria D, CHRISTENSEN, Dale J

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Edelfosine lipid nanosystems overcome drug resistance in leukemic cell lines von Lasa-Saracíbar, Beatriz, Estella-Hermoso de Mendoza, Ander, Mollinedo, Faustino, Odero, María D, Blanco-Príeto, María J

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MYC-dependent recruitment of RUNX1 and GATA2 on the SET oncogene promoter enhances PP2A inactivation in acute myeloid leukemia von Pippa, Raffaella, Dominguez, Ana, Malumbres, Raquel, Endo, Akinori, Arriazu, Elena, Marcotegui, Nerea, Guruceaga, Elizabeth, Odero, María D

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The role of the GATA2 transcription factor in normal and malignant hematopoiesis von Vicente, Carmen, Conchillo, Ana, García-Sánchez, María A, Odero, María D

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Overexpression of SET is a recurrent event associated with poor outcome and contributes to protein phosphatase 2A inhibition in acute myeloid leukemia von CRISTOBAL, Ion, GARCIA-ORTI, Laura, CIRAUQUI, Cristina, CORTES-LAVAUD, Xabier, GARCIA-SANCHEZ, Maria A, CALASANZ, Maria J, ODERO, Maria D

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SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia von Cristóbal, Ion, Blanco, Francisco J., Garcia-Orti, Laura, Marcotegui, Nerea, Vicente, Carmen, Rifon, José, Novo, Francisco J., Bandres, Eva, Calasanz, María J., Bernabeu, Carmelo, Odero, María D.

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A novel FTY720 analogue targets SET-PP2A interaction and inhibits growth of acute myeloid leukemia cells without inducing cardiac toxicity von Vicente, Carmen, Arriazu, Elena, Martínez-Balsalobre, Elena, Peris, Irene, Marcotegui, Nerea, García-Ramírez, Patricia, Pippa, Raffaella, Rabal, Obdulia, Oyarzábal, Julen, Guruceaga, Elizabeth, Prósper, Felipe, Mateos, María C., Cayuela, María L., Odero, María D.

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GATA2 germline mutations impair GATA2 transcription, causing haploinsufficiency: functional analysis of the p.Arg396Gln mutation von Cortés-Lavaud, Xabier, Landecho, Manuel F, Maicas, Miren, Urquiza, Leire, Merino, Juana, Moreno-Miralles, Isabel, Odero, María D

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NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder von VIZMANOS, José L, NOVO, Francisco J, ROMAN, José P, BAXTER, E. Joanna, LAHORTIGA, Idoya, LARRAYOZ, Maria J, ODERO, Maria D, GIRALDO, Pilar, CALASANZ, Maria J, CROSS, Nicholas C. P

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The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias von Pippa, Raffaella, Odero, Maria D.

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Integration of SNP and mRNA arrays with microRNA profiling reveals that MiR-370 is upregulated and targets NF1 in acute myeloid leukemia von García-Ortí, Laura, Cristóbal, Ion, Cirauqui, Cristina, Guruceaga, Elisabet, Marcotegui, Nerea, Calasanz, María J, Castello-Cros, Remedios, Odero, María D

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The MDS and EVI1 complex locus (MECOM) isoforms regulate their own transcription and have different roles in the transformation of hematopoietic stem and progenitor cells von Maicas, Miren, Vázquez, Iria, Alis, Rafael, Marcotegui, Nerea, Urquiza, Leire, Cortés-Lavaud, Xabier, Cristóbal, Ion, García-Sánchez, María A., Odero, María D.

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CIP2A high expression is a poor prognostic factor in normal karyotype acute myeloid leukemia von Barragán, Eva, Chillón, María Carmen, Castelló-Cros, Remedios, Marcotegui, Nerea, Prieto, María Isabel, Hoyos, Montserrat, Pippa, Raffaella, Llop, Marta, Etxabe, Amaia, Cervera, José, Rodríguez, Gabriela, Buño, Ismael, Rifón, José, Sierra, Jorge, González, Marcos, Calasanz, María J, Sanz, Miguel A, Odero, María D

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A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia von Arriazu, Elena, Vicente, Carmen, Pippa, Raffaella, Peris, Irene, Martínez-Balsalobre, Elena, García-Ramírez, Patricia, Marcotegui, Nerea, Igea, Ana, Alignani, Diego, Rifón, José, Mateos, María C., Cayuela, María L., Nebreda, Angel R., Odero, María D.

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Molecular heterogeneity in AML/MDS patients with 3q21q26 rearrangements von Lahortiga, Idoya, Vázquez, Iria, Agirre, Xabier, Larrayoz, María J., Vizmanos, José L., Gozzetti, Alessandro, Calasanz, María J., Odero, María D.

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p53 Aberrations do not predict individual response to fludarabine in patients with B‐cell chronic lymphocytic leukaemia in advanced stages Rai III/IV von Valgañón, Mikel, Giraldo, Pilar, Agirre, Xabier, Larráyoz, María J., Rubio‐Martinez, Araceli, Rubio‐Felix, Daniel, Calasanz, María J., Odero, María D.

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