Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor von Stepan, Antonia F, Subramanyam, Chakrapani, Efremov, Ivan V, Dutra, Jason K, O’Sullivan, Theresa J, DiRico, Kenneth J, McDonald, W. Scott, Won, Annie, Dorff, Peter H, Nolan, Charles E, Becker, Stacey L, Pustilnik, Leslie R, Riddell, David R, Kauffman, Gregory W, Kormos, Bethany L, Zhang, Liming, Lu, Yasong, Capetta, Steven H, Green, Michael E, Karki, Kapil, Sibley, Evelyn, Atchison, Kevin P, Hallgren, Andrew J, Oborski, Christine E, Robshaw, Ashley E, Sneed, Blossom, O’Donnell, Christopher J

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Spirocyclic Sulfamides as β‑Secretase 1 (BACE-1) Inhibitors for the Treatment of Alzheimer’s Disease: Utilization of Structure Based Drug Design, WaterMap, and CNS Penetration Stud... von Brodney, Michael A, Barreiro, Gabriela, Ogilvie, Kevin, Hajos-Korcsok, Eva, Murray, John, Vajdos, Felix, Ambroise, Claude, Christoffersen, Curt, Fisher, Katherine, Lanyon, Lorraine, Liu, JianHua, Nolan, Charles E, Withka, Jane M, Borzilleri, Kris A, Efremov, Ivan, Oborski, Christine E, Varghese, Alison, O’Neill, Brian T

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Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design von Efremov, Ivan V, Vajdos, Felix F, Borzilleri, Kris A, Capetta, Steven, Chen, Hou, Dorff, Peter H, Dutra, Jason K, Goldstein, Steven W, Mansour, Mahmoud, McColl, Alexander, Noell, Stephen, Oborski, Christine E, O’Connell, Thomas N, O’Sullivan, Theresa J, Pandit, Jayvardhan, Wang, Hong, Wei, BinQing, Withka, Jane M

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Pharmacodynamics and Pharmacokinetics of the γ-Secretase Inhibitor PF-3084014 von Lanz, Thomas A., Wood, Kathleen M., Richter, Karl E.G., Nolan, Charles E., Becker, Stacey L., Pozdnyakov, Nikolay, Martin, Barbara-Anne, Du, Ping, Oborski, Christine E., Wood, Douglas E., Brown, Tracy M., Finley, James E., Sokolowski, Sharon A., Hicks, Carol D., Coffman, Karen J., Geoghegan, Kieran F., Brodney, Michael A., Liston, Dane, Tate, Barbara

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Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014 von Brodney, Michael A., Auperin, David D., Becker, Stacey L., Bronk, Brian S., Brown, Tracy M., Coffman, Karen J., Finley, James E., Hicks, Carol D., Karmilowicz, Michael J., Lanz, Thomas A., Liston, Dane, Liu, Xingrong, Martin, Barbara-Anne, Nelson, Robert B., Nolan, Charles E., Oborski, Christine E., Parker, Christine P., Richter, Karl E.G., Pozdnyakov, Nikolay, Sahagan, Barbara G., Schachter, Joel B., Sokolowski, Sharon A., Tate, Barbara, Wood, Douglas E., Wood, Kathleen M., Van Deusen, Jeffrey W., Zhang, Lei

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Diamide amino-imidazoles: A novel series of γ-secretase inhibitors for the treatment of Alzheimer’s disease von Brodney, Michael A., Auperin, David D., Becker, Stacey L., Bronk, Brian S., Brown, Tracy M., Coffman, Karen J., Finley, James E., Hicks, Carol D., Karmilowicz, Michael J., Lanz, Thomas A., Liston, Dane, Liu, Xingrong, Martin, Barbara-Anne, Nelson, Robert B., Nolan, Charles E., Oborski, Christine E., Parker, Christine P., Richter, Karl E.G., Pozdnyakov, Nikolay, Sahagan, Barbara G., Schachter, Joel B., Sokolowski, Sharon A., Tate, Barbara, Van Deusen, Jeffrey W., Wood, Douglas E., Wood, Kathleen M.

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Thiazole-diamides as potent γ-secretase inhibitors von Chen, Yuhpyng L., Cherry, Kevin, Corman, Michael L., Ebbinghaus, Charles F., Gamlath, Chandra B., Liston, Dane, Martin, Barbara-Anne, Oborski, Christine E., Sahagan, Barbara G.

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Using single-point pharmacokinetic/pharmacodynamic (PK/PD) analyses to support early discovery of inhibitors of β-site APP cleaving enzyme 1 (BACE1) von Lu, Yasong, Liu, Jianhua, Nelson, Frederick, Ambroise, Claude, Fisher, Katherine, Hajos-Korcsok, Eva, Noell, Stephen, Nolan, Charles E, Oborski, Christine E, Lanyon, Lorraine F, Christoffersen, Curt, Hannah, Divine, Efremov, Ivan, Helal, Chris, Brodney, Michael A, O'Neill, Brian T

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Layered geology of Australia von Sanchez, G, Stewart, A.J, Liu, S.F, Highet, L, Woods, M, Brown, C, Bonnardot, M, Beyer, E, Clark, A, Connors, K, Wong, S, Cayley, R, Skladzien, P, Czarnota, K, Buddee, M, MaraisvanVuuren, C, Cassells, L, Oborski, E, Knepprath, N, Bryant, C, Werner, M

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Pharmacological Assessment of γ-Secretase Activity from Rodent and Human Brain von Oborski, Christine E., Iyer, Rathna, Maguire, Bruce A., Bora, Gary, Atchison, Kevin, Pozdnyakov, Nikolay, Wood, Kathleen, Parker, Christine, Subashi, Timothy A., Pettersson, Martin, Johnson, Douglas S., Bales, Kelly R.

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P3‐313: Using single‐point pharmacokinetic/pharmacodynamic (PK/PD) analyses to support early discovery of inhibitors of β‐site APP cleaving enzyme 1 (BACE1) von Lu, Yasong, Liu, Jianhua, Nelson, Frederick, Ambroise, Claude, Fisher, Katherine, Hajos-Korcsok, Eva, Noell, Stephen, Nolan, Charles E., Oborski, Christine E., Lanyon, Lorraine F., Christoffersen, Curt, Hannah, Divine, Efremov, Ivan, Helal, Chris, Brodney, Michael A., O'Neill, Brian T.

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Layered geology of Australia von Sanchez, G, Stewart, A.J, Liu, S.F, Highet, L, Woods, M, Brown, C, Bonnardot, M, Beyer, E, Clark, A, Connors, K, Wong, S, Cayley, R, Skladzien, P, Czarnota, K, Buddee, M, MaraisvanVuuren, C, Cassells, L, Oborski, E, Knepprath, N, Bryant, C, Werner, M

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ChemInform Abstract: Thiazole-Diamides as Potent γ-Secretase Inhibitors von Chen, Yuhpyng L., Cherry, Kevin, Corman, Michael L., Ebbinghaus, Charles F., Gamlath, Chandra B., Liston, Dane, Martin, Barbara-Anne, Oborski, Christine E., Sahagan, Barbara G.

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Errors in Quantitative Image Analysis due to Platform-Dependent Image Scaling von Chenevert, Thomas L, Malyarenko, Dariya I, Newitt, David, Li, Xin, Jayatilake, Mohan, Tudorica, Alina, Fedorov, Andriy, Kikinis, Ron, Liu, Tiffany Ting, Muzi, Mark, Oborski, Matthew J, Laymon, Charles M, Li, Xia, Thomas, Yankeelov, Jayashree, Kalpathy-Cramer, Mountz, James M, Kinahan, Paul E, Rubin, Daniel L, Fennessy, Fiona, Huang, Wei, Hylton, Nola, Ross, Brian D

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Variations of Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Evaluation of Breast Cancer Therapy Response: A Multicenter Data Analysis Challenge von Huang, Wei, Li, Xin, Chen, Yiyi, Li, Xia, Chang, Ming-Ching, Oborski, Matthew J, Malyarenko, Dariya I, Muzi, Mark, Jajamovich, Guido H, Fedorov, Andriy, Tudorica, Alina, Gupta, Sandeep N, Laymon, Charles M, Marro, Kenneth I, Dyvorne, Hadrien A, Miller, James V, Barbodiak, Daniel P, Chenevert, Thomas L, Yankeelov, Thomas E, Mountz, James M, Kinahan, Paul E, Kikinis, Ron, Taouli, Bachir, Fennessy, Fiona, Kalpathy-Cramer, Jayashree

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Multi‐site quality and variability analysis of 3D FDG PET segmentations based on phantom and clinical image data von Beichel, Reinhard R., Smith, Brian J., Bauer, Christian, Ulrich, Ethan J., Ahmadvand, Payam, Budzevich, Mikalai M., Gillies, Robert J., Goldgof, Dmitry, Grkovski, Milan, Hamarneh, Ghassan, Huang, Qiao, Kinahan, Paul E., Laymon, Charles M., Mountz, James M., Muzi, John P., Muzi, Mark, Nehmeh, Sadek, Oborski, Matthew J., Tan, Yongqiang, Zhao, Binsheng, Sunderland, John J., Buatti, John M.

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Exquisite Sensitivity to Dual BRG1/BRM ATPase Inhibitors Reveals Broad SWI/SNF Dependencies in Acute Myeloid Leukemia von Rago, Florencia, Rodrigues, Lindsey Ulkus, Bonney, Megan, Sprouffske, Kathleen, Kurth, Esther, Elliott, GiNell, Ambrose, Jessi, Aspesi, Peter, Oborski, Justin, Chen, Julie T, McDonald, E Robert, Mapa, Felipa A, Ruddy, David A, Kauffmann, Audrey, Abrams, Tinya, Bhang, Hyo-Eun C, Jagani, Zainab

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Screening chimeric GAA variants in preclinicalstudy results in hematopoietic stem cell genetherapy candidate vectors for Pompe disease von Dogan, Yildirim, Barese, Cecilia N., Schindler, Jeffrey W., Yoon, John K., Unnisa, Zeenath, Guda, Swaroopa, Jacobs, Mary E., Oborski, Christine, Maiwald, Tim, Clarke, Diana L., Schambach, Axel, Pfeifer, Richard, Harper, Claudia, Mason, Chris, van Til, Niek P.

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Preclinical lentiviral hematopoietic stem cell gene therapy corrects Pompe disease-related muscle and neurological manifestations von Yoon, John K., Schindler, Jeffrey W., Loperfido, Mariana, Baricordi, Cristina, DeAndrade, Mark P., Jacobs, Mary E., Treleaven, Christopher, Plasschaert, Robert N., Yan, Aimin, Barese, Cecilia N., Dogan, Yildirim, Chen, Vicky Ping, Fiorini, Claudia, Hull, Fritz, Barbarossa, Luigi, Unnisa, Zeenath, Ivanov, Daniel, Kutner, Robert H., Guda, Swaroopa, Oborski, Christine, Maiwald, Tim, Michaud, Véronique, Rothe, Michael, Schambach, Axel, Pfeifer, Richard, Mason, Chris, Biasco, Luca, van Til, Niek P.

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The Impact of Arterial Input Function Determination Variations on Prostate Dynamic Contrast-Enhanced Magnetic Resonance Imaging Pharmacokinetic Modeling: A Multicenter Data Analysi... von Huang, Wei, Chen, Yiyi, Fedorov, Andriy, Li, Xia, Jajamovich, Guido H, Malyarenko, Dariya I, Aryal, Madhava P, LaViolette, Peter S, Oborski, Matthew J, O'Sullivan, Finbarr, Abramson, Richard G, Jafari-Khouzani, Kourosh, Afzal, Aneela, Tudorica, Alina, Moloney, Brendan, Gupta, Sandeep N, Besa, Cecilia, Kalpathy-Cramer, Jayashree, Mountz, James M, Laymon, Charles M, Muzi, Mark, Schmainda, Kathleen, Cao, Yue, Chenevert, Thomas L, Taouli, Bachir, Yankeelov, Thomas E, Fennessy, Fiona, Li, Xin

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