Eighteen-Year Disease Progression and Survival in CADASIL von Gravesteijn, Gido, Hack, Remco J, Opstal, Anna M van, van Eijsden, Bastian J, Middelkoop, Huub A M, Rodriguez Girondo, Mar D M, Aartsma-Rus, Annemieke, Grond, Jeroen van de, Rutten, Julie W, Oberstein, Saskia A J Lesnik

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Cysteine-Altering NOTCH3 Variants Are a Risk Factor for Stroke in the Elderly Population von Hack, Remco J., Rutten, Julie W., Person, Thomas N., Li, Jiang, Khan, Ayesha, Griessenauer, Christoph J., Abedi, Vida, Lesnik Oberstein, Saskia A.J., Zand, Ramin

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Lacunar infarcts are the main correlate with cognitive dysfunction in cadasil von LIEM, Michael K, VAN DER GROND, Jeroen, HAAN, Joost, BOOM, Rivka Van Den, FERRARI, Michel D, KNAAP, Yvette M, BREUNING, Martijn H, VAN BUCHEM, Mark A, MIDDELKOOP, Huub A. M, OBERSTEIN, Saskia A. J. Lesnik

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NOTCH3 VARIANT POSITION IS ASSOCIATED WITH VASCULAR NOTCH3 AGGREGATION LOAD IN CADASIL PATIENTS von Gravesteijn, Gido, Hack, Remco J., Mulder, Aat A., Cerfontaine, Minne N., van Doorn, Remco, Hegeman, Ingrid M., Jost, Carolina R., Rutten, Julie W., Oberstein, Saskia A.J. Lesnik

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The effect of NOTCH3 pathogenic variant position on CADASIL disease severity: NOTCH3 EGFr 1–6 pathogenic variant are associated with a more severe phenotype and lower survival comp... von Rutten, Julie W., Van Eijsden, Bastian J., Duering, Marco, Jouvent, Eric, Opherk, Christian, Pantoni, Leonardo, Federico, Antonio, Dichgans, Martin, Markus, Hugh S., Chabriat, Hugues, Lesnik Oberstein, Saskia A. J.

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Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and managem... von Di Donato, Ilaria, Bianchi, Silvia, De Stefano, Nicola, Dichgans, Martin, Dotti, Maria Teresa, Duering, Marco, Jouvent, Eric, Korczyn, Amos D, Lesnik-Oberstein, Saskia A J, Malandrini, Alessandro, Markus, Hugh S, Pantoni, Leonardo, Penco, Silvana, Rufa, Alessandra, Sinanović, Osman, Stojanov, Dragan, Federico, Antonio

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Hereditary Cerebral Small Vessel Diseases and Stroke: A Guide for Diagnosis and Management von Guey, Stéphanie, Lesnik Oberstein, Saskia A.J., Tournier-Lasserve, Elisabeth, Chabriat, Hugues

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What's in a Domain? The Role of NOTCH3 EGFr Domains in CADASIL Disease Severity von Hack, Remco, Rutten, Julie, Lesnik Oberstein, Saskia A.J.

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Three-tiered EGFr domain risk stratification for individualized NOTCH3-small vessel disease prediction von Hack, Remco J, Gravesteijn, Gido, Cerfontaine, Minne N, Santcroos, Mark A, Gatti, Laura, Kopczak, Anna, Bersano, Anna, Duering, Marco, Rutten, Julie W, Lesnik Oberstein, Saskia A J

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NOTCH3 variant position is associated with NOTCH3 aggregation load in CADASIL vasculature von Gravesteijn, Gido, Hack, Remco J., Mulder, Aat A., Cerfontaine, Minne N., Doorn, Remco, Hegeman, Ingrid M., Jost, Carolina R., Rutten, Julie W., Lesnik Oberstein, Saskia A. J.

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Effect of NOTCH3 EGFr Group, Sex, and Cardiovascular Risk Factors on CADASIL Clinical and Neuroimaging Outcomes von Hack, Remco J., Cerfontaine, Minne N., Gravesteijn, Gido, Tap, Stephan, Hafkemeijer, Anne, van der Grond, Jeroen, Witjes-Ané, Marie-Noëlle, Baas, Frank, Rutten, Julie W., Lesnik Oberstein, Saskia A.J.

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Engineered 3D vessel-on-chip using hiPSC-derived endothelial- and vascular smooth muscle cells von Vila Cuenca, Marc, Cochrane, Amy, van den Hil, Francijna E., de Vries, Antoine A.F., Lesnik Oberstein, Saskia A.J., Mummery, Christine L., Orlova, Valeria V.

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Broad phenotype of cysteine-altering NOTCH3 variants in UK Biobank: CADASIL to nonpenetrance von Rutten, Julie W., Hack, Remco J., Duering, Marco, Gravesteijn, Gido, Dauwerse, Johannes G., Overzier, Maurice, van den Akker, Erik B., Slagboom, Eline, Holstege, Henne, Nho, Kwangsik, Saykin, Andrew, Dichgans, Martin, Malik, Rainer, Lesnik Oberstein, Saskia A.J.

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Association of NOTCH3 Variant Risk Category With 2-Year Clinical and Radiologic Small Vessel Disease Progression in Patients With CADASIL von Cerfontaine, Minne N, Hack, Remco J, Gesierich, Benno, Duering, Marco, Witjes-Ané, Marie-Noëlle W, Rodríguez-Girondo, Mar, Gravesteijn, Gido, Rutten, Julie, Lesnik Oberstein, Saskia A J

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Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Family Members With a Pathogenic NOTCH3 Variant Can Have a Normal Brain Magnetic Resonanc... von Hack, Remco J., Gravesteijn, Gido, Cerfontaine, Minne N., Hegeman, Ingrid M., Mulder, Aat A., Lesnik Oberstein, Saskia A.J., Rutten, Julie W.

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Therapeutic NOTCH3 cysteine correction in CADASIL using exon skipping: in vitro proof of concept von Rutten, Julie W, Dauwerse, Hans G, Peters, Dorien J M, Goldfarb, Andrew, Venselaar, Hanka, Haffner, Christof, van Ommen, Gert-Jan B, Aartsma-Rus, Annemieke M, Lesnik Oberstein, Saskia A J

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Hereditary Cerebral Small Vessel Diseases and Stroke: A Guide for Diagnosis and Management von Guey, Stéphanie, Lesnik Oberstein, Saskia A.J., Tournier-Lasserve, Elisabeth, Chabriat, Hugues

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Epilepsy in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy von Haan, Joost, Lesnik Oberstein, Saskia A.J., Ferrari, Michel D.

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Archetypal NOTCH3 mutations frequent in public exome: implications for CADASIL von Rutten, Julie W., Dauwerse, Hans G., Gravesteijn, Gido, Belzen, Martine J., Grond, Jeroen, Polke, James M., Bernal‐Quiros, Manuel, Lesnik Oberstein, Saskia A. J.

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Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model von Oliveira, Daniel V, Coupland, Kirsten G, Shao, Wenchao, Jin, Shaobo, Del Gaudio, Francesca, Wang, Sailan, Fox, Rhys, Rutten, Julie W, Sandin, Johan, Zetterberg, Henrik, Lundkvist, Johan, Lesnik Oberstein, Saskia AJ, Lendahl, Urban, Karlström, Helena

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