Evaluation of Various Static and Dynamic Modeling Methods to Predict Clinical CYP3A Induction Using In Vitro CYP3A4 mRNA Induction Data von Einolf, H J, Chen, L, Fahmi, O A, Gibson, C R, Obach, R S, Shebley, M, Silva, J, Sinz, M W, Unadkat, J D, Zhang, L, Zhao, P

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Evaluation of Various Static In Vitro-In Vivo Extrapolation Models for Risk Assessment of the CYP3A Inhibition Potential of an Investigational Drug von Vieira, Md L T, Kirby, B, Ragueneau-Majlessi, I, Galetin, A, Chien, J Y L, Einolf, H J, Fahmi, O A, Fischer, V, Fretland, A, Grime, K, Hall, S D, Higgs, R, Plowchalk, D, Riley, R, Seibert, E, Skordos, K, Snoeys, J, Venkatakrishnan, K, Waterhouse, T, Obach, R S, Berglund, E G, Zhang, L, Zhao, P, Reynolds, K S, Huang, S-M

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Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates von Lombardo, M N, G-Dayanandan, N, Keshipeddy, S, Zhou, W, Si, D, Reeve, S M, Alverson, J, Barney, P, Walker, L, Hoody, J, Priestley, N D, Obach, R S, Wright, D L

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Effect of Human Renal Cationic Transporter Inhibition on the Pharmacokinetics of Varenicline, a New Therapy for Smoking Cessation: An In Vitro–In Vivo Study von Feng, B, Obach, RS, Burstein, AH, Clark, DJ, Morais, SM, Faessel, HM

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Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug-drug interaction risk assessment von Venkatakrishnan, K., Obach, R. S., Rostami-Hodjegan, A.

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The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metab... von Nguyen, Hoa Q, Callegari, Ernesto, Obach, R Scott

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An Automated High-Throughput Metabolic Stability Assay Using an Integrated High-Resolution Accurate Mass Method and Automated Data Analysis Software von Shah, Pranav, Kerns, Edward, Nguyen, Dac-Trung, Obach, R Scott, Wang, Amy Q, Zakharov, Alexey, McKew, John, Simeonov, Anton, Hop, Cornelis E C A, Xu, Xin

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Heterotropic Effects on Drug‐Metabolizing Enzyme Activities: In Vitro Curiosity Emerges as a Clinically Meaningful Phenomenon (Perhaps?) von Obach, R S

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Metabolites in Safety Testing: "MIST" for the Clinical Pharmacologist von Frederick, C B, Obach, R S

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Human Liver Aldehyde Oxidase: Inhibition by 239 Drugs von Obach, R. Scott, Huynh, Phuong, Allen, Mary C., Beedham, Christine

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The effect of CP‐99994 on the responses to provocative motion in the cat von Lucot, J B, Obach, R S, McLean, S, Watson, J W

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Strategy for genotoxicity testing—Metabolic considerations von Ku, Warren W., Bigger, Anita, Brambilla, Giovanni, Glatt, Hansruedi, Gocke, Elmar, Guzzie, Peggy J., Hakura, Atsushi, Honma, Masamitsu, Martus, Hans-Joerg, Obach, R. Scott, Roberts, Stanley

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Examination of 209 Drugs for Inhibition of Cytochrome P450 2C8 von Walsky, Robert L., Gaman, Emily A., Obach, R. Scott

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Mechanistic Modeling to Predict Midazolam Metabolite Exposure from In Vitro Data von Nguyen, Hoa Q, Kimoto, Emi, Callegari, Ernesto, Obach, R Scott

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Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes von Eng, Heather, Obach, R Scott

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Biosynthesis of Fluorinated Analogs of Drugs Using Human Cytochrome P450 Enzymes Followed by Deoxyfluorination and Quantitative Nuclear Magnetic Resonance Spectroscopy to Improve M... von Obach, R Scott, Walker, Gregory S, Brodney, Michael A

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Application of a Micropatterned Cocultured Hepatocyte System To Predict Preclinical and Human-Specific Drug Metabolism von Ballard, T Eric, Wang, Shuai, Cox, Loretta M, Moen, Mark A, Krzyzewski, Stacy, Ukairo, Okechukwu, Obach, R Scott

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Drugs that inhibit oxidation reactions catalyzed by aldehyde oxidase do not inhibit the reductive metabolism of ziprasidone to its major metabolite, S-methyldihydroziprasidone : An... von OBACH, R. Scott, WALSKY, Robert L

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Metabolites and Safety:  What Are the Concerns, and How Should We Address Them? von Smith, Dennis A., Obach, R. Scott

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Pharmacokinetics of ezlopitant, a novel non-peptidic neurokinin-1 receptor antagonist in preclinical species and metabolite kinetics of the pharmacologically active metabolites von Reed-Hagen, Anne E., Tsuchiya, Megumi, Shimada, Kaoru, Wentland, Jo-Ann, Obach, R. Scott

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