Structure–activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling von Ahmed, Ahmed Abdullah, Chen, Shuang, Roman-Escorza, Maria, Angell, Richard, Oxenford, Sally, McConville, Matthew, Barton, Naomi, Sunose, Mihiro, Neidle, Dan, Haider, Shozeb, Arshad, Tariq, Neidle, Stephen

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Regulation of metastasis suppressor NME1 by a key metabolic cofactor coenzyme A von Yu, Bess Yi Kun, Tossounian, Maria-Armineh, Hristov, Stefan Denchev, Lawrence, Ryan, Arora, Pallavi, Tsuchiya, Yugo, Peak-Chew, Sew Yeu, Filonenko, Valeriy, Oxenford, Sally, Angell, Richard, Gouge, Jerome, Skehel, Mark, Gout, Ivan

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Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry von Mazzon, Michela, Ortega-Prieto, Ana Maria, Imrie, Douglas, Luft, Christin, Hess, Lena, Czieso, Stephanie, Grove, Joe, Skelton, Jessica Katy, Farleigh, Laura, Bugert, Joachim J, Wright, Edward, Temperton, Nigel, Angell, Richard, Oxenford, Sally, Jacobs, Michael, Ketteler, Robin, Dorner, Marcus, Marsh, Mark

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Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models von Ahmed, Ahmed A, Angell, Richard, Oxenford, Sally, Worthington, Jenny, Williams, Nicole, Barton, Naomi, Fowler, Thomas G, O’Flynn, Daniel E, Sunose, Mihiro, McConville, Matthew, Vo, Tam, Wilson, W. David, Karim, Saadia A, Morton, Jennifer P, Neidle, Stephen

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Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases von Riccio, Federica, Talapatra, Sandeep K, Oxenford, Sally, Angell, Richard, Mazzon, Michela, Kozielski, Frank

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cis- and trans-Stereoselective Epoxidation of N-Protected 2-Cyclohexen-1-ylamines von O'Brien, Peter, Childs, Amanda C, Ensor, Gareth J, Hill, Cheryl L, Kirby, Jonathan P, Dearden, Michael J, Oxenford, Sally J, Rosser, Clare M

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Substituted Naphthalenedimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology von Vo, Tam, Oxenford, Sally, Angell, Richard, Marchetti, Chiara, Ohnmacht, Stephan A., Wilson, W. David, Neidle, Stephen

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[YIA] Regulation of metastasis suppressor NME1 by a key metabolic cofactor coenzyme A von Kun Yu, Bess Yi, Tossounian, Maria-Armineh, Hristov, Stefan Denchev, Arora, Pallavi, Tsuchiyaugo, Yugo, Peak-Chew, Sew Yeu, Oxenford, Sally, Angell, Richard, Gouge, Jerome, Skehel, Mark, Gout, Ivan

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Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth von Salinas, Tomas Raul Wiche, Zhang, Yuwei, Sarnello, Daniele, Zhyvoloup, Alexander, Marchand, Laurence Raymond, Fert, Augustine, Planas, Delphine, Lodha, Manivel, Chatterjee, Debashree, Karwacz, Katarzyna, Oxenford, Sally, Routy, Jean-Pierre, Irlbeck, David, Amrine-Madsen, Heather, Ancuta, Petronela, Fassati, Ariberto

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A small-molecule PI3Kα activator for cardioprotection and neuroregeneration von Gong, Grace Q., Bilanges, Benoit, Allsop, Ben, Masson, Glenn R., Roberton, Victoria, Askwith, Trevor, Oxenford, Sally, Madsen, Ralitsa R., Conduit, Sarah E., Bellini, Dom, Fitzek, Martina, Collier, Matt, Najam, Osman, He, Zhenhe, Wahab, Ben, McLaughlin, Stephen H., Chan, A. W. Edith, Feierberg, Isabella, Madin, Andrew, Morelli, Daniele, Bhamra, Amandeep, Vinciauskaite, Vanesa, Anderson, Karen E., Surinova, Silvia, Pinotsis, Nikos, Lopez-Guadamillas, Elena, Wilcox, Matthew, Hooper, Alice, Patel, Chandni, Whitehead, Maria A., Bunney, Tom D., Stephens, Len R., Hawkins, Phillip T., Katan, Matilda, Yellon, Derek M., Davidson, Sean M., Smith, David M., Phillips, James B., Angell, Richard, Williams, Roger L., Vanhaesebroeck, Bart

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Abstract 4069: The potent quadruplex-binding compound SOP1812 shows anti-tumor activity in patient-derived in vivo models of pancreatic cancer von Neidle, Stephen, Ahmed, Ahmed, Angell, Richard, Oxenford, Sally

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Regulation of metastasis suppressor NME1 by a key metabolic cofactor coenzyme A von Kun Yu, Bess Yi, Tossounian, Maria-Armineh, Hristov, Stefan Denchev, Lawrence, Ryan, Arora, Pallavi, Tsuchiya, Yugo, Peak-Chew, Sew Yeu, Oxenford, Sally, Angell, Richard, Gouge, Jerome, Skehel, Mark, Gout, Ivan

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Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology von Vo, Tam, Oxenford, Sally, Angell, Richard, Marchetti, Chiara, Ohnmacht, Stephan A, Wilson, W. David, Neidle, Stephen

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Scope and limitations of the catalytic asymmetric rearrangement of epoxides to allylic alcohols using chiral lithium amide bases/lithiated imidazoles von Oxenford, Sally J., Wright, Jonathan M., O’Brien, Peter, Panday, Narendra, Shipton, Mark R.

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Asymmetric synthesis via aziridinium ions: exploring the stereospecificity of the ring opening of aziridinium ions and a formal synthesis of (−)-swainsonine von Oxenford, Sally J., Moore, Stephen P., Carbone, Giorgio, Barker, Graeme, O’Brien, Peter, Shipton, Mark R., Gilday, John, Campos, Kevin R.

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SMALL-MOLECULE INHIBITORS OF THE FRS2-FGFR INTERACTION von OXENFORD, Sally, KUMAR, Karthiga

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Chiral base route to functionalised cyclopentenyl amines: formal synthesis of the cyclopentene core of nucleoside Q von Oxenford, Sally J., O’Brien, Peter, Shipton, Mark R.

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SUBSTITUTED NAPHTHALENE DIIMIDES AND THEIR USE von Oxenford, Sally, Angell, Richard, Neidle, Stephen

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Substituted naphthalene diimides and their use von Oxenford, Sally, Angell, Richard, Neidle, Stephen

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Structure–activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling von Ahmed, Ahmed Abdullah, Chen, Shuang, Roman-Escorza, Maria, Angell, Richard, Oxenford, Sally, McConville, Matthew, Barton, Naomi, Sunose, Mihiro, Neidle, Dan, Haider, Shozeb, Arshad, Tariq, Neidle, Stephen

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