Fast segmentation of stained nuclei in terabyte-scale, time resolved 3D microscopy image stacks von Stegmaier, Johannes, Otte, Jens C, Kobitski, Andrei, Bartschat, Andreas, Garcia, Ariel, Nienhaus, G Ulrich, Strähle, Uwe, Mikut, Ralf

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Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves von Takamiya, Masanari, Stegmaier, Johannes, Kobitski, Andrei Yu, Schott, Benjamin, Weger, Benjamin D, Margariti, Dimitra, Cereceda Delgado, Angel R, Gourain, Victor, Scherr, Tim, Yang, Lixin, Sorge, Sebastian, Otte, Jens C, Hartmann, Volker, van Wezel, Jos, Stotzka, Rainer, Reinhard, Thomas, Schlunck, Gunther, Dickmeis, Thomas, Rastegar, Sepand, Mikut, Ralf, Nienhaus, Gerd Ulrich, Strahle, Uwe

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The fish embryo test (FET): origin, applications, and future von Braunbeck, Thomas, Kais, Britta, Lammer, Eva, Otte, Jens, Schneider, Katharina, Stengel, Daniel, Strecker, Ruben

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EmbryoMiner: A new framework for interactive knowledge discovery in large-scale cell tracking data of developing embryos von Schott, Benjamin, Traub, Manuel, Schlagenhauf, Cornelia, Takamiya, Masanari, Antritter, Thomas, Bartschat, Andreas, Löffler, Katharina, Blessing, Denis, Otte, Jens C, Kobitski, Andrei Y, Nienhaus, G Ulrich, Strähle, Uwe, Mikut, Ralf, Stegmaier, Johannes

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Heterogeneity in biological assemblages and exposure in chemical risk assessment: Exploring capabilities and challenges in methodology with two landscape-scale case studies von Holmes, Christopher M., Maltby, Lorraine, Sweeney, Paul, Thorbek, Pernille, Otte, Jens C., Marshall, Stuart

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Spatio-temporal development of CYP1 activity in early life-stages of zebrafish ( Danio rerio) von Otte, Jens C., Schmidt, Annette D., Hollert, Henner, Braunbeck, Thomas

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Intrinsic Xenobiotic Metabolizing Enzyme Activities in Early Life Stages of Zebrafish (Danio rerio) von Otte, Jens C, Schultz, Bernadette, Fruth, Daniela, Fabian, Eric, van Ravenzwaay, Bennard, Hidding, Björn, Salinas, Edward R

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Contribution of priority PAHs and POPs to Ah receptor-mediated activities in sediment samples from the River Elbe Estuary, Germany von Otte, Jens C, Keiter, Steffen, Faßbender, Christopher, Higley, Eric B, Rocha, Paula Suares, Brinkmann, Markus, Wahrendorf, Dierk-Steffen, Manz, Werner, Wetzel, Markus A, Braunbeck, Thomas, Giesy, John P, Hecker, Markus, Hollert, Henner

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Three-tiered approach for standard information requirements for polymers requiring registration under REACH von Otte, Jens C., Hollnagel, Heli Miriam, Nagel, Christiane, Gerhardt, Renata Friederike, Wohlleben, Wendel, Vallotton, Nathalie, Schowanek, Diederik, Sanders, Gordon, Frasca, Joe M., Mahale, Tushar, Pemberton, Mark, Hidding, Bjoern, Landsiedel, Robert

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Moving persistence assessments into the 21st century: A role for weight‐of‐evidence and overall persistence von Redman, Aaron D., Bietz, Jens, Davis, John W., Lyon, Delina, Maloney, Erin, Ott, Amelie, Otte, Jens C., Palais, Frédéric, Parsons, John R., Wang, Neil

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Impacts of different exposure scenarios on transcript abundances in Danio rerio embryos when investigating the toxicological burden of riverine sediments von Bluhm, Kerstin, Otte, Jens C, Yang, Lixin, Zinsmeister, Christian, Legradi, Jessica, Keiter, Steffen, Kosmehl, Thomas, Braunbeck, Thomas, Strähle, Uwe, Hollert, Henner

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An ensemble-averaged, cell density-based digital model of zebrafish embryo development derived from light-sheet microscopy data with single-cell resolution von Kobitski, Andrei Y., Otte, Jens C., Takamiya, Masanari, Schäfer, Benjamin, Mertes, Jonas, Stegmaier, Johannes, Rastegar, Sepand, Rindone, Francesca, Hartmann, Volker, Stotzka, Rainer, García, Ariel, van Wezel, Jos, Mikut, Ralf, Strähle, Uwe, Nienhaus, G. Ulrich

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A combined DNA-microarray and mechanism-specific toxicity approach with zebrafish embryos to investigate the pollution of river sediments von Kosmehl, Thomas, Otte, Jens C., Yang, Lixin, Legradi, Jessica, Bluhm, Kerstin, Zinsmeister, Christian, Keiter, Steffen H., Reifferscheid, Georg, Manz, Werner, Braunbeck, Thomas, Strähle, Uwe, Hollert, Henner

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Relative differences in aryl hydrocarbon receptor-mediated response for 18 polybrominated and mixed halogenated dibenzo-P-dioxins and -furans in cell lines from four different spec... von Olsman, Helena, Engwall, Magnus, Kammann, Ulrike, Klempt, Martin, Otte, Jens, van Bavel, Bert, Hollert, Henner

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Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos von Hausen, Jonas, Otte, Jens C., Legradi, Jessica, Yang, Lixin, Strähle, Uwe, Fenske, Martina, Hecker, Markus, Tang, Song, Hammers-Wirtz, Monika, Hollert, Henner, Keiter, Steffen H., Ottermanns, Richard

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Toxicity, dioxin-like activities, and endocrine effects of DDT metabolites—DDA, DDMU, DDMS, and DDCN von Wetterauer, Bernhard, Ricking, Mathias, Otte, Jens C., Hallare, Arnold V., Rastall, Andrew, Erdinger, Lothar, Schwarzbauer, Jan, Braunbeck, Thomas, Hollert, Henner

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Fold-change threshold screening: a robust algorithm to unmask hidden gene expression patterns in noisy aggregated transcriptome data von Hausen, Jonas, Otte, Jens C., Strähle, Uwe, Hammers-Wirtz, Monika, Hollert, Henner, Keiter, Steffen H., Ottermanns, Richard

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DanTox—a novel joint research project using zebrafish (Danio rerio) to identify specific toxicity and molecular modes of action of sediment-bound pollutants von Keiter, Steffen, Peddinghaus, Sabrina, Feiler, Ute, von der Goltz, Britta, Hafner, Christoph, Ho, Nga Yu, Rastegar, Sepand, Otte, Jens C, Ottermanns, Richard, Reifferscheid, Georg, Strähle, Uwe, Braunbeck, Thomas, Hammers-Wirtz, Monika, Hollert, Henner

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A bioassay approach to determine the dioxin-like activity in sediment extracts from the Danube River: Ethoxyresorufin- O-deethylase induction in gill filaments and liver of three-s... von Otte, Jens C., Andersson, Carin, Abrahamson, Alexandra, Olsman, Helena, Keiter, Steffen, Engwall, Magnus, Hollert, Henner, Brunström, Björn

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Which endpoints of a zebrafish embryotoxicity assay improve its predictivity? von Flick, Burkhard, Jiang, Xiaoqi, Salinas, Edward, Birk, Barbara, Dammann, Martina, Otte, Jens, Mellert, Werner, Hidding, Bjoern, Landsiedel, Robert, van Ravenzwaay, Bennard

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