(Electro)chemical N2 Splitting by a Molybdenum Complex with an Anionic PNP Pincer-Type Ligand von Ostermann, Nils, Rotthowe, Nils, Stückl, A. Claudia, Siewert, Inke

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Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors von Vulpetti, Anna, Randl, Stefan, Rüdisser, Simon, Ostermann, Nils, Erbel, Paul, Mac Sweeney, Aengus, Zoller, Thomas, Salem, Bahaa, Gerhartz, Bernd, Cumin, Frederic, Hommel, Ulrich, Dalvit, Claudio, Lorthiois, Edwige, Maibaum, Jürgen

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A genetics-led approach defines the drug target landscape of 30 immune-related traits von Fang, Hai, De Wolf, Hans, Knezevic, Bogdan, Burnham, Katie L., Osgood, Julie, Sanniti, Anna, Lledó Lara, Alicia, Kasela, Silva, De Cesco, Stephane, Wegner, Jörg K., Handunnetthi, Lahiru, McCann, Fiona E., Chen, Liye, Sekine, Takuya, Brennan, Paul E., Marsden, Brian D., Damerell, David, O’Callaghan, Chris A., Bountra, Chas, Bowness, Paul, Sundström, Yvonne, Milani, Lili, Berg, Louise, Göhlmann, Hinrich W., Peeters, Pieter J., Fairfax, Benjamin P., Sundström, Michael, Knight, Julian C.

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Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes von Sutton, Jon M., Clark, David E., Dunsdon, Stephen J., Fenton, Garry, Fillmore, Amanda, Harris, Neil V., Higgs, Chris, Hurley, Chris A., Krintel, Sussie L., MacKenzie, Robert E., Duttaroy, Alokesh, Gangl, Eric, Maniara, Wiesia, Sedrani, Richard, Namoto, Kenji, Ostermann, Nils, Gerhartz, Bernd, Sirockin, Finton, Trappe, Jörg, Hassiepen, Ulrich, Baeschlin, Daniel K.

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Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV von Namoto, Kenji, Sirockin, Finton, Ostermann, Nils, Gessier, Francois, Flohr, Stefanie, Sedrani, Richard, Gerhartz, Bernd, Trappe, Jörg, Hassiepen, Ulrich, Duttaroy, Alokesh, Ferreira, Suzie, Sutton, Jon M., Clark, David E., Fenton, Garry, Beswick, Mandy, Baeschlin, Daniel K.

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A Nickel Complex with a Proton-Responsive PNP Pincer-Type Ligand as a Proton-Coupled Electron Transfer Reagent von Mukherjee, Jyotima, Ostermann, Nils, Aniban, Xaiza, Safianova, Inna, Rotthowe, Nils, Mata, Ricardo, Siewert, Inke

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Electrochemical N2 splitting at well-defined metal complexes von Ostermann, Nils, Siewert, Inke

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Exploring T Cell Reactivity to Gliadin in Young Children with Newly Diagnosed Celiac Disease von McDaniel, Kristen, Liu, Edwin, Case, Stephanie, Yu, Liping, Gerhartz, Bernd, Ostermann, Nils, Fankhauser, Gabriela, Hungerford, Valerie, Zou, Chao, Luyten, Marcel, Seidl, Katherine J., Michels, Aaron W.

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Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C von Weiss, Andreas, Lorthiois, Edwige, Barys, Louise, Beyer, Kim S, Bomio-Confaglia, Claudio, Burks, Heather, Chen, Xueying, Cui, Xiaoming, de Kanter, Ruben, Dharmarajan, Lekshmi, Fedele, Carmine, Gerspacher, Marc, Guthy, Daniel Alexander, Head, Victoria, Jaeger, Ashley, Núñez, Eloísa Jiménez, Kearns, Jeffrey D, Leblanc, Catherine, Maira, Sauveur-Michel, Murphy, Jason, Oakman, Helen, Ostermann, Nils, Ottl, Johannes, Rigollier, Pascal, Roman, Danielle, Schnell, Christian, Sedrani, Richard, Shimizu, Toshio, Stringer, Rowan, Vaupel, Andrea, Voshol, Hans, Wessels, Peter, Widmer, Toni, Wilcken, Rainer, Xu, Kun, Zecri, Frederic, Farago, Anna F, Cotesta, Simona, Brachmann, Saskia M

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Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4 von Fairhurst, Robin A, Knoepfel, Thomas, Buschmann, Nicole, Leblanc, Catherine, Mah, Robert, Todorov, Milen, Nimsgern, Pierre, Ripoche, Sebastien, Niklaus, Michel, Warin, Nicolas, Luu, Van Huy, Madoerin, Mario, Wirth, Jasmin, Graus-Porta, Diana, Weiss, Andreas, Kiffe, Michael, Wartmann, Markus, Kinyamu-Akunda, Jacqueline, Sterker, Dario, Stamm, Christelle, Adler, Flavia, Buhles, Alexandra, Schadt, Heiko, Couttet, Philippe, Blank, Jutta, Galuba, Inga, Trappe, Jörg, Voshol, Johannes, Ostermann, Nils, Zou, Chao, Berghausen, Jörg, Del Rio Espinola, Alberto, Jahnke, Wolfgang, Furet, Pascal

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JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors von Lorthiois, Edwige, Gerspacher, Marc, Beyer, Kim S., Vaupel, Andrea, Leblanc, Catherine, Stringer, Rowan, Weiss, Andreas, Wilcken, Rainer, Guthy, Daniel A., Lingel, Andreas, Bomio-Confaglia, Claudio, Machauer, Rainer, Rigollier, Pascal, Ottl, Johannes, Arz, Dorothee, Bernet, Pascal, Desjonqueres, Gaëlle, Dussauge, Solene, Kazic-Legueux, Malika, Lozac’h, Marie-Anne, Mura, Christophe, Sorge, Mickaël, Todorov, Milen, Warin, Nicolas, Zink, Florence, Voshol, Hans, Zecri, Frederic J., Sedrani, Richard C., Ostermann, Nils, Brachmann, Saskia M., Cotesta, Simona

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Redox‐Active Heteroatom‐Functionalized Polyacetylenes von Luppi, Bruno T., Muralidharan, Abhishek V., Ostermann, Nils, Cheong, I T., Ferguson, Michael J., Siewert, Inke, Rivard, Eric

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Design and Biochemical Characterization of Peptidic Inhibitors of the Myb/p300 Interaction von Jones, Matthew, Grosche, Philipp, Floersheimer, Andreas, André, Jérome, Gattlen, Raphael, Oser, Dieter, Tinchant, Juliette, Wille, Roman, Chie-Leon, Barbara, Gerspacher, Marc, Ertl, Peter, Ostermann, Nils, Altmann, Eva, Manchado, Eusebio, Vorherr, Thomas, Chène, Patrick

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(Electro)chemical N 2 Splitting by a Molybdenum Complex with an Anionic PNP Pincer-Type Ligand von Ostermann, Nils, Rotthowe, Nils, Stückl, A Claudia, Siewert, Inke

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Small-molecule factor D inhibitors targeting the alternative complement pathway von Maibaum, Jürgen, Liao, Sha-Mei, Vulpetti, Anna, Ostermann, Nils, Randl, Stefan, Rüdisser, Simon, Lorthiois, Edwige, Erbel, Paul, Kinzel, Bernd, Kolb, Fabrice A, Barbieri, Samuel, Wagner, Julia, Durand, Corinne, Fettis, Kamal, Dussauge, Solene, Hughes, Nicola, Delgado, Omar, Hommel, Ulrich, Gould, Ty, Mac Sweeney, Aengus, Gerhartz, Bernd, Cumin, Frederic, Flohr, Stefanie, Schubart, Anna, Jaffee, Bruce, Harrison, Richard, Risitano, Antonio Maria, Eder, Jörg, Anderson, Karen

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Structural Basis for Efficient Phosphorylation of 3′-azidothymidine Monophosphate by Escherichia coli Thymidylate Kinase von Lavie, Arnon, Ostermann, Nils, Brundiers, Ralf, Goody, Roger S., Reinstein, Jochen, Konrad, Manfred, Schlichting, Ilme

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Abstract P124: JDQ443, a covalent irreversible inhibitor of KRAS G12C, exhibits a novel binding mode and demonstrates potent anti-tumor activity and favorable pharmacokinetic prope... von Brachmann, Saskia M., Weiss, Andreas, Guthy, Daniel A., Beyer, Kim, Voshol, Johannes, Maira, Michel, Prahallad, Anirudh, Porta, Diana Graus, Schnell, Christian, Ostermann, Nils, Vaupel, Andrea, Gerspacher, Marc, Leblanc, Catherine, Erdmann, Dirk, Sterker, Dario, Kerr, Grainne, Jerome, Giovannoni, Head, Victoria, Stringer, Rowan, De Kanter, Ruben, Jeff, Kearns, Roman, Danielle, Widmer, Toni, Wessels, Peter, Nunez, Eloisa Jimenez, Sedrani, Richard, Zecri, Frederic, Hofmann, Francesco, Engleman, Jeff, Lorthiois, Edwige, Cotesta, Simona

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JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS G12C for the Treatment of Solid Tumors von Lorthiois, Edwige, Gerspacher, Marc, Beyer, Kim S, Vaupel, Andrea, Leblanc, Catherine, Stringer, Rowan, Weiss, Andreas, Wilcken, Rainer, Guthy, Daniel A, Lingel, Andreas, Bomio-Confaglia, Claudio, Machauer, Rainer, Rigollier, Pascal, Ottl, Johannes, Arz, Dorothee, Bernet, Pascal, Desjonqueres, Gaëlle, Dussauge, Solene, Kazic-Legueux, Malika, Lozac'h, Marie-Anne, Mura, Christophe, Sorge, Mickaël, Todorov, Milen, Warin, Nicolas, Zink, Florence, Voshol, Hans, Zecri, Frederic J, Sedrani, Richard C, Ostermann, Nils, Brachmann, Saskia M, Cotesta, Simona

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Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo von Lorthiois, Edwige, Anderson, Karen, Vulpetti, Anna, Rogel, Olivier, Cumin, Frederic, Ostermann, Nils, Steinbacher, Stefan, Mac Sweeney, Aengus, Delgado, Omar, Liao, Sha-Mei, Randl, Stefan, Rüdisser, Simon, Dussauge, Solene, Fettis, Kamal, Kieffer, Laurence, de Erkenez, Andrea, Yang, Louis, Hartwieg, Constanze, Argikar, Upendra A, La Bonte, Laura R, Newton, Ronald, Kansara, Viral, Flohr, Stefanie, Hommel, Ulrich, Jaffee, Bruce, Maibaum, Jürgen

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Gift from Nature: Cyclomarin A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action von Bürstner, Nathalie, Roggo, Silvio, Ostermann, Nils, Blank, Jutta, Delmas, Cecile, Freuler, Felix, Gerhartz, Bernd, Hinniger, Alexandra, Hoepfner, Dominic, Liechty, Brigitta, Mihalic, Manuel, Murphy, Jason, Pistorius, Dominik, Rottmann, Matthias, Thomas, Jason R., Schirle, Markus, Schmitt, Esther K.

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