The PTEN/NRF2 axis promotes human carcinogenesis von Rojo, Ana I, Rada, Patricia, Mendiola, Marta, Ortega-Molina, Ana, Wojdyla, Katarzyna, Rogowska-Wrzesinska, Adelina, Hardisson, David, Serrano, Manuel, Cuadrado, Antonio

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Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity von Ortega-Molina, Ana, Efeyan, Alejo, Lopez-Guadamillas, Elena, Muñoz-Martin, Maribel, Gómez-López, Gonzalo, Cañamero, Marta, Mulero, Francisca, Pastor, Joaquin, Martinez, Sonia, Romanos, Eduardo, Mar Gonzalez-Barroso, M., Rial, Eduardo, Valverde, Angela M., Bischoff, James R., Serrano, Manuel

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From mouse genetics to targeting the Rag GTPase pathway von Ortega-Molina, Ana, Efeyan, Alejo

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Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling von de la Calle Arregui, Celia, Plata-Gómez, Ana Belén, Deleyto-Seldas, Nerea, García, Fernando, Ortega-Molina, Ana, Abril-Garrido, Julio, Rodriguez, Elena, Nemazanyy, Ivan, Tribouillard, Laura, de Martino, Alba, Caleiras, Eduardo, Campos-Olivas, Ramón, Mulero, Francisca, Laplante, Mathieu, Muñoz, Javier, Pende, Mario, Sabio, Guadalupe, Sabatini, David M., Efeyan, Alejo

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Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs von Ortega-Molina, Ana, Lebrero-Fernández, Cristina, Sanz, Alba, Deleyto-Seldas, Nerea, Plata-Gómez, Ana Belén, Menéndez, Camino, Graña-Castro, Osvaldo, Caleiras, Eduardo, Efeyan, Alejo

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NGFR regulates stromal cell activation in germinal centers von Hernández-Barranco, Alberto, Santos, Vanesa, Mazariegos, Marina S., Caleiras, Eduardo, Nogués, Laura, Mourcin, Frédéric, Léonard, Simon, Oblet, Christelle, Genebrier, Steve, Rossille, Delphine, Benguría, Alberto, Sanz, Alba, Vázquez, Enrique, Dopazo, Ana, Efeyan, Alejo, Ortega-Molina, Ana, Cogne, Michel, Tarte, Karin, Peinado, Héctor

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Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin von EFEYAN, Alejo, ORTEGA-MOLINA, Ana, VELASCO-MIGUEL, Susana, HERRANZ, Daniel, VASSILEV, Lyubomir T, SERRANO, Manuel

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PTEN in cancer, metabolism, and aging von Ortega-Molina, Ana, Serrano, Manuel

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A minimally invasive assay for individual assessment of the ATM/CHEK2/p53 pathway activity von Kabacik, Sylwia, Ortega-Molina, Ana, Efeyan, Alejo, Finnon, Paul, Bouffler, Simon, Serrano, Manuel, Badie, Christophe

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Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression von Efeyan, Alejo, Murga, Matilde, Martinez-Pastor, Barbara, Ortega-Molina, Ana, Soria, Rebeca, Collado, Manuel, Fernandez-Capetillo, Oscar, Serrano, Manuel

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A Cell Engineering Strategy to Enhance the Safety of Stem Cell Therapies von Oricchio, Elisa, Papapetrou, Eirini P., Lafaille, Fabien, Ganat, Yosif M., Kriks, Sonja, Ortega-Molina, Ana, Mark, Willie H., Teruya-Feldstein, Julie, Huse, Jason T., Reuter, Victor, Sadelain, Michel, Studer, Lorenz, Wendel, Hans-Guido

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Correction: Limited Role of Murine ATM in Oncogene-Induced Senescence and p53-Dependent Tumor Suppression von Efeyan, Alejo, Murga, Matilde, Martinez-Pastor, Barbara, Ortega-Molina, Ana, Soria, Rebeca, Collado, Manuel, Fernandez-Capetillo, Oscar, Serrano, Manuel

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The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development von Ortega-Molina, Ana, Boss, Isaac W, Canela, Andres, Pan, Heng, Jiang, Yanwen, Zhao, Chunying, Jiang, Man, Hu, Deqing, Agirre, Xabier, Niesvizky, Itamar, Lee, Ji-Eun, Chen, Hua-Tang, Ennishi, Daisuke, Scott, David W, Mottok, Anja, Hother, Christoffer, Liu, Shichong, Cao, Xing-Jun, Tam, Wayne, Shaknovich, Rita, Garcia, Benjamin A, Gascoyne, Randy D, Ge, Kai, Shilatifard, Ali, Elemento, Olivier, Nussenzweig, Andre, Melnick, Ari M, Wendel, Hans-Guido

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CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas von Jiang, Yanwen, Ortega-Molina, Ana, Geng, Huimin, Ying, Hsia-Yuan, Hatzi, Katerina, Parsa, Sara, McNally, Dylan, Wang, Ling, Doane, Ashley S, Agirre, Xabier, Teater, Matt, Meydan, Cem, Li, Zhuoning, Poloway, David, Wang, Shenqiu, Ennishi, Daisuke, Scott, David W, Stengel, Kristy R, Kranz, Janice E, Holson, Edward, Sharma, Sneh, Young, James W, Chu, Chi-Shuen, Roeder, Robert G, Shaknovich, Rita, Hiebert, Scott W, Gascoyne, Randy D, Tam, Wayne, Elemento, Olivier, Wendel, Hans-Guido, Melnick, Ari M

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PTEN recruitment controls synaptic and cognitive function in Alzheimer's models von Knafo, Shira, Sánchez-Puelles, Cristina, Palomer, Ernest, Delgado, Igotz, Draffin, Jonathan E, Mingo, Janire, Wahle, Tina, Kaleka, Kanwardeep, Mou, Liping, Pereda-Perez, Inmaculada, Klosi, Edvin, Faber, Erik B, Chapman, Heidi M, Lozano-Montes, Laura, Ortega-Molina, Ana, Ordóñez-Gutiérrez, Lara, Wandosell, Francisco, Viña, Jose, Dotti, Carlos G, Hall, Randy A, Pulido, Rafael, Gerges, Nashaat Z, Chan, Andrew M, Spaller, Mark R, Serrano, Manuel, Venero, César, Esteban, José A

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Pharmacological Inhibition of PI3K Reduces Adiposity and Metabolic Syndrome in Obese Mice and Rhesus Monkeys von Ortega-Molina, Ana, Lopez-Guadamillas, Elena, Mattison, Julie A., Mitchell, Sarah J., Muñoz-Martin, Maribel, Iglesias, Gema, Gutierrez, Vincent M., Vaughan, Kelli L., Szarowicz, Mark D., González-García, Ismael, López, Miguel, Cebrián, David, Martinez, Sonia, Pastor, Joaquin, de Cabo, Rafael, Serrano, Manuel

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Oncogenic Rag GTPase signalling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR von Ortega-Molina, Ana, Deleyto-Seldas, Nerea, Carreras, Joaquim, Sanz, Alba, Lebrero-Fernández, Cristina, Menéndez, Camino, Vandenberg, Andrew, Fernández-Ruiz, Beatriz, Marín-Arraiza, Leyre, de la Calle Arregui, Celia, Plata-Gómez, Ana Belén, Caleiras, Eduardo, de Martino, Alba, Martínez-Martín, Nuria, Troulé, Kevin, Piñeiro-Yáñez, Elena, Nakamura, Naoya, Araf, Shamzah, Victora, Gabriel D., Okosun, Jessica, Fitzgibbon, Jude, Efeyan, Alejo

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Abstract IA13: Oncogenic Rag GTPase signaling links cellular nutrients with the FL microenvironment von Ortega-Molina, Ana, Lebrero-Fernández, Cristina, Deleyto-Seldas, Nerea, Sanz, Alba, Efeyan, Alejo

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Abstract 1183: Metabolic characterization of follicular lymphoma transformation von Poore, Brad, Ortega-Molina, Ana, Nguyen, Christopher, Zhao, Liang, Blackwell, Anne, Hartung, Thomas, Wendel, Hans-Guido, Le, Anne

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A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan von Ortega-Molina, Ana, Lebrero-Fernández, Cristina, Sanz, Alba, Calvo-Rubio, Miguel, Deleyto-Seldas, Nerea, de Prado-Rivas, Lucía, Plata-Gómez, Ana Belén, Fernández-Florido, Elena, González-García, Patricia, Vivas-García, Yurena, Sánchez García, Elena, Graña-Castro, Osvaldo, Price, Nathan L, Aroca-Crevillén, Alejandra, Caleiras, Eduardo, Monleón, Daniel, Borrás, Consuelo, Casanova-Acebes, María, de Cabo, Rafael, Efeyan, Alejo

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