Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function von Lee, Young-hee, Martin-Orozco, Natalia, Zheng, Peilin, Li, Jing, Zhang, Peng, Tan, Haidong, Park, Hyun Jung, Jeong, Mira, Chang, Seon Hee, Kim, Byung-Seok, Xiong, Wei, Zang, Wenjuan, Guo, Li, Liu, Yang, Dong, Zhong-jun, Overwijk, Willem W, Hwu, Patrick, Yi, Qing, Kwak, Larry, Yang, Zhiying, Mak, Tak W, Li, Wei, Radvanyi, Laszlo G, Ni, Ling, Liu, Dongfang, Dong, Chen

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Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells von Martin-Orozco, Natalia, Chung, Yeonseok, Chang, Seon Hee, Wang, Yi-Hong, Dong, Chen

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Comparison of a SARS-CoV-2 mRNA booster immunization containing additional antigens to a spike-based mRNA vaccine against Omicron BA.5 infection in hACE2 mice von Hurst, Jacklyn R, Naghibosadat, Maedeh, Budowski, Patrick, Liu, Jun, Samaan, Philip, Budiman, Frans, Kurtesi, Alexandra, Qi, Fredo, Menon, Haritha, Krishnan, Rajesh, Abioye, Jumai, Gingras, Anne-Claude, Ostrowski, Mario, Orozco, Natalia Martin, Kozak, Robert A

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Comparable safety and non-inferior immunogenicity of the SARS-CoV-2 mRNA vaccine candidate PTX-COVID19-B and BNT162b2 in a phase 2 randomized, observer-blinded study von Reiter, Lawrence, Greffrath, Johann, Zidel, Bian, Ostrowski, Mario, Gommerman, Jennifer, Madhi, Shabir A., Tran, Richard, Martin-Orozco, Natalia, Panicker, Rajesh Krishnan Gopalakrishna, Cooper, Curtis, Pastrak, Aleksandra

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Phase I randomized, observer-blinded, placebo-controlled study of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B von Martin-Orozco, Natalia, Vale, Noah, Mihic, Alan, Amor, Talya, Reiter, Lawrence, Arita, Yuko, Samson, Reuben, Hu, Queenie, Gingras, Anne-Claude, Sorenson, Bradley Thomas, Marcusson, Eric Gates, Patel, Piyush

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CD226 and TIGIT Cooperate in the Differentiation and Maturation of Human Tfh Cells von Yasutomi, Motoko, Christiaansen, Allison F, Imai, Naoko, Martin-Orozco, Natalia, Forst, Christian V, Chen, Gang, Ueno, Hideki

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T-cell tolerance or function is determined by combinatorial costimulatory signals von Nurieva, Roza, Thomas, Sunil, Nguyen, Thang, Martin-Orozco, Natalia, Wang, Ying, Kaja, Murali-Krishna, Yu, Xue-Zhong, Dong, Chen

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Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B von Liu, Jun, Budylowski, Patrick, Samson, Reuben, Griffin, Bryan D, Babuadze, Giorgi, Rathod, Bhavisha, Colwill, Karen, Abioye, Jumai A, Schwartz, Jordan A, Law, Ryan, Yip, Lily, Ahn, Sang Kyun, Chau, Serena, Naghibosadat, Maedeh, Arita, Yuko, Hu, Queenie, Yue, Feng Yun, Banerjee, Arinjay, Hardy, W Rod, Mossman, Karen, Mubareka, Samira, Kozak, Robert A, Pollanen, Michael S, Martin Orozco, Natalia, Gingras, Anne-Claude, Marcusson, Eric G, Ostrowski, Mario A

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MKP-1 Is Necessary for T Cell Activation and Function von Zhang, Yongliang, Reynolds, Joseph M., Chang, Seon Hee, Martin-Orozco, Natalia, Chung, Yeonseok, Nurieva, Roza I., Dong, Chen

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A bivalent COVID-19 mRNA vaccine elicited broad immune responses and protection against Omicron subvariants infection von Liu, Jun, Wang, Li, Kurtesi, Alexandra, Budylowski, Patrick, Potts, Kyle G., Menon, Haritha, Tan, Yilin, Samaan, Philip, Liu, Xinan, Wang, Yisen, Hu, Queenie, Samson, Reuben, Qi, Freda, Evseev, Danyel, John, Cini, Ellestad, Kristofor K., Fan, Yue, Budiman, Frans, Tohan, Ellaine Riczly, Udayakumar, Suji, Yang, Jennifer, Marcusson, Eric G., Gingras, Anne-Claude, Mahoney, Douglas J., Ostrowski, Mario A., Martin-Orozco, Natalia

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Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice von Lamothe, Betty, Lai, Yunju, Hur, Lana, Orozco, Natalia Martin, Wang, Jing, Campos, Alejandro D, Xie, Min, Schneider, Michael D, Lockworth, Cynthia R, Jakacky, Jared, Tran, Diep, Ho, Michael, Dawud, Sity, Dong, Chen, Lin, Hui-Kuan, Hu, Peter, Estrov, Zeev, Bueso-Ramos, Carlos E, Darnay, Bryant G

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Defective positive selection results in T cell lymphopenia and increased autoimmune diabetes in ADAP-deficient BDC2.5-C57BL/6 mice von Zou, Liangxing, Mendez, Felipe, Martin-Orozco, Natalia, Peterson, Erik J

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New battlefields for costimulation von Martin-Orozco, Natalia, Dong, Chen

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IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients von Sim, Geok Choo, Martin-Orozco, Natalia, Jin, Lei, Yang, Yan, Wu, Sheng, Washington, Edwina, Sanders, Deborah, Lacey, Carol, Wang, Yijun, Vence, Luis, Hwu, Patrick, Radvanyi, Laszlo

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T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity von Martin-Orozco, Natalia, Muranski, Pawel, Chung, Yeonseok, Yang, Xuexian O., Yamazaki, Tomohide, Lu, Sijie, Hwu, Patrick, Restifo, Nicholas P., Overwijk, Willem W., Dong, Chen

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Bcl6 expression specifies the T follicular helper cell program in vivo von Liu, Xindong, Yan, Xiaowei, Zhong, Bo, Nurieva, Roza I, Wang, Aibo, Wang, Xiaohu, Martin-Orozco, Natalia, Wang, Yihong, Chang, Seon Hee, Esplugues, Enric, Flavell, Richard A, Tian, Qiang, Dong, Chen

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Molecular and cellular mechanisms underlying iron transport deficiency in microcytic anemia von Touret, Nicolas, Martin-Orozco, Natalia, Paroutis, Paul, Furuya, Wendy, Lam-Yuk-Tseung, Steven, Forbes, John, Gros, Philippe, Grinstein, Sergio

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T cells and T cell tumors efficiently generate antigen-specific cytotoxic T cell immunity when modified with an NKT ligand von Chung, Yeonseok, Lee, Young-Hee, Zhang, Yongliang, Martin-Orozco, Natalia, Yamazaki, Tomohide, Zhou, Dapeng, Kang, Chang-Yuil, Hwu, Patrick, Kwak, Larry W., Dong, Chen

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CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells von Yamazaki, Tomohide, Yang, Xuexian O, Chung, Yeonseok, Fukunaga, Atsushi, Nurieva, Roza, Pappu, Bhanu, Martin-Orozco, Natalia, Kang, Hong Soon, Ma, Li, Panopoulos, Athanasia D, Craig, Suzanne, Watowich, Stephanie S, Jetten, Anton M, Tian, Qiang, Dong, Chen

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EXTH-15. AN EGFRVIII RNA-LNP VACCINE PROTOTYPE ACHIEVES TUMOUR CLEARANCE IN A GBM MOUSE MODEL von Snelling, Shannon, Nechanitzky, Robert, Lun, Xueqing, Ellestad, Kristofer, Pyczek, Joanna, Olsen, Kirsten, Wu, Yu, Karpov, Yury, Liu, Jun, Gold, Matthew, Menon, Haritha, Tan, Yilin, Krishnan, Rajesh, Mahoney, Douglas, Martin-Orozco, Natalia, Chan, Jennifer A

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