Functional characterization of a PROTAC directed against BRAF mutant V600E von Posternak, Ganna, Tang, Xiaojing, Maisonneuve, Pierre, Jin, Ting, Lavoie, Hugo, Daou, Salima, Orlicky, Stephen, Goullet de Rugy, Theo, Caldwell, Lauren, Chan, Kin, Aman, Ahmed, Prakesch, Michael, Poda, Gennady, Mader, Pavel, Wong, Cassandra, Maier, Stefan, Kitaygorodsky, Julia, Larsen, Brett, Colwill, Karen, Yin, Zhe, Ceccarelli, Derek F., Batey, Robert A., Taipale, Mikko, Kurinov, Igor, Uehling, David, Wrana, Jeff, Durocher, Daniel, Gingras, Anne-Claude, Al-Awar, Rima, Therrien, Marc, Sicheri, Frank

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Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1–F-box interface von Gorelik, Maryna, Orlicky, Stephen, Sartori, Maria A., Tang, Xiaojing, Marcon, Edyta, Kurinov, Igor, Greenblatt, Jack F., Tyers, Mike, Moffat, Jason, Sicheri, Frank, Sidhu, Sachdev S.

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Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor von Mittag, Tanja, Orlicky, Stephen, Choy, Wing-Yiu, Tang, Xiaojing, Lin, Hong, Sicheri, Frank, Kay, Lewis E, Tyers, Mike, Forman-Kay, Julie D

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An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase von Orlicky, Stephen, Tang, Xiaojing, Neduva, Victor, Elowe, Nadine, Brown, Eric D, Sicheri, Frank, Tyers, Mike

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An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme von Ceccarelli, Derek F., Tang, Xiaojing, Pelletier, Benoit, Orlicky, Stephen, Xie, Weilin, Plantevin, Veronique, Neculai, Dante, Chou, Yang-Chieh, Ogunjimi, Abiodun, Al-Hakim, Abdallah, Varelas, Xaralabos, Koszela, Joanna, Wasney, Gregory A., Vedadi, Masoud, Dhe-Paganon, Sirano, Cox, Sarah, Xu, Shuichan, Lopez-Girona, Antonia, Mercurio, Frank, Wrana, Jeff, Durocher, Daniel, Meloche, Sylvain, Webb, David R., Tyers, Mike, Sicheri, Frank

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FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation von Barbulescu, Philip, Chana, Chetan K., Wong, Matthew K., Ben Makhlouf, Ines, Bruce, Jeffrey P., Feng, Yuqing, Keszei, Alexander F. A., Wong, Cassandra, Mohamad-Ramshan, Rukshana, McGary, Laura C., Kashem, Mohammad A., Ceccarelli, Derek F., Orlicky, Stephen, Fang, Yifei, Kuang, Huihui, Mazhab-Jafari, Mohammad, Pezo, Rossanna C., Bhagwat, Ashok S., Pugh, Trevor J., Gingras, Anne-Claude, Sicheri, Frank, Martin, Alberto

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A substrate binding model for the KEOPS tRNA modifying complex von Beenstock, Jonah, Ona, Samara Mishelle, Porat, Jennifer, Orlicky, Stephen, Wan, Leo C. K., Ceccarelli, Derek F., Maisonneuve, Pierre, Szilard, Rachel K., Yin, Zhe, Setiaputra, Dheva, Mao, Daniel Y. L., Khan, Morgan, Raval, Shaunak, Schriemer, David C., Bayfield, Mark A., Durocher, Daniel, Sicheri, Frank

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An allosteric conduit facilitates dynamic multisite substrate recognition by the SCFCdc4 ubiquitin ligase von Csizmok, Veronika, Orlicky, Stephen, Cheng, Jing, Song, Jianhui, Bah, Alaji, Delgoshaie, Neda, Lin, Hong, Mittag, Tanja, Sicheri, Frank, Chan, Hue Sun, Tyers, Mike, Forman-Kay, Julie D.

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Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity von Huang, Hao, Zeqiraj, Elton, Dong, Beihua, Jha, Babal Kant, Duffy, Nicole M., Orlicky, Stephen, Thevakumaran, Neroshan, Talukdar, Manisha, Pillon, Monica C., Ceccarelli, Derek F., Wan, Leo C.K., Juang, Yu-Chi, Mao, Daniel Y.L., Gaughan, Christina, Brinton, Margo A., Perelygin, Andrey A., Kourinov, Igor, Guarné, Alba, Silverman, Robert H., Sicheri, Frank

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Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication von Pawson, Tony, Tyers, Mike, Nash, Piers, Tang, Xiaojing, Orlicky, Stephen, Chen, Qinghua, Gertler, Frank B, Mendenhall, Michael D, Sicheri, Frank

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Suprafacial Orientation of the SCFCdc4 Dimer Accommodates Multiple Geometries for Substrate Ubiquitination von Tang, Xiaojing, Orlicky, Stephen, Lin, Zhenyuan, Willems, Andrew, Neculai, Dante, Ceccarelli, Derek, Mercurio, Frank, Shilton, Brian H., Sicheri, Frank, Tyers, Mike

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Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase von Tang, Xiaojing, Orlicky, Stephen, Mittag, Tanja, Csizmok, Veronika, Pawson, Tony, Forman-Kay, Julie D, Sicheri, Frank, Tyers, Mike

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Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine von Mao, Daniel Y.L., Neculai, Dante, Downey, Michael, Orlicky, Stephen, Haffani, Yosr Z., Ceccarelli, Derek F., Ho, Jenny S.L., Szilard, Rachel K., Zhang, Wei, Ho, Cynthia S., Wan, Leo, Fares, Christophe, Rumpel, Sigrun, Kurinov, Igor, Arrowsmith, Cheryl H., Durocher, Daniel, Sicheri, Frank

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Molecular Characterization of a Toluene-Degrading Methanogenic Consortium von FICKER, M, KRASTEL, K, ORLICKY, S, EDWARDS, E

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SCFCdc4 Enables Mating Type Switching in Yeast by Cyclin-Dependent Kinase-Mediated Elimination of the Ash1 Transcriptional Repressor von Liu, Qingquan, Larsen, Brett, Ricicova, Marketa, Orlicky, Stephen, Tekotte, Hille, Tang, Xiaojing, Craig, Karen, Quiring, Adam, Le Bihan, Thierry, Hansen, Carl, Sicheri, Frank, Tyers, Mike

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SCFFBXW7 regulates G2‐M progression through control of CCNL1 ubiquitination von O'Brien, Siobhan, Kelso, Susan, Steinhart, Zachary, Orlicky, Stephen, Mis, Monika, Kim, Yunhye, Lin, Sichun, Sicheri, Frank, Angers, Stephane

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SCF FBXW7 regulates G2-M progression through control of CCNL1 ubiquitination von O'Brien, Siobhan, Kelso, Susan, Steinhart, Zachary, Orlicky, Stephen, Mis, Monika, Kim, Yunhye, Lin, Sichun, Sicheri, Frank, Angers, Stephane

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Bi-partite binding of the N-terminus of Skp2 to cyclin A von Kelso, Susan, Orlicky, Stephen, Beenstock, Jonah, Ceccarelli, Derek F., Kurinov, Igor, Gish, Gerald, Sicheri, Frank

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Structure/Function Implications in a Dynamic Complex of the Intrinsically Disordered Sic1 with the Cdc4 Subunit of an SCF Ubiquitin Ligase von Mittag, Tanja, Marsh, Joseph, Grishaev, Alexander, Orlicky, Stephen, Lin, Hong, Sicheri, Frank, Tyers, Mike, Forman-Kay, Julie D.

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Bipartite binding of the N terminus of Skp2 to cyclin A von Kelso, Susan, Orlicky, Stephen, Beenstock, Jonah, Ceccarelli, Derek F., Kurinov, Igor, Gish, Gerald, Sicheri, Frank

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